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Synthesis 1989; 1989(1): 28-30
DOI: 10.1055/s-1989-27135
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A New Synthesis of 1-n-Alkyl-3,5-dimethoxybenzenes (Olivetol Dimethyl Ether and Homologs)

Ugo Azzena* , Teresa Denurra, Emma Fenude, Giovanni Melloni, Gloria Rassu
  • *Dipartimento di Chimica, Università di Sassari, Via Vienna 2, I-07100 Sassari, Italy
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Publication Date:
27 September 2002 (online)

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An efficient method is reported for the synthesis of 1-n-alkyl-3,5-dimethoxybenzenes, useful intermediates in the synthesis of cannabinoids, from the readily available and cheap 3,4,5-trimethoxybenzoic acid. The key step is the electron-transfer induced highly regioselective demethoxylation of 1-n-alkyl-3,4,5-trimethoxybenzenes.

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