A One-Pot Synthesis of Sandwicoline and its Three Diastereoisomers from Related Alkaloids

S. Salman Ahmad; S. Imtiaz Haider; S. Siddiqui

doi:10.1055/s-1988-27613

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Synthesis 1988; 1988(6): 478
DOI: 10.1055/s-1988-27613

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A One-Pot Synthesis of Sandwicoline and its Three Diastereoisomers from Related Alkaloids

S. Salman Ahmad^* , S. Imtiaz Haider, S. Siddiqui

^*H. E. J. Research Institute of Chemistry, University of Karachi, Karachi-32, Pakistan

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Publikationsdatum:
20. August 2002 (online)

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The Rauwolfia alkaloid sandwicoline and its three diastereoisomers were synthesized via reduction and methylation (NaBH₄/CH₃I) of sandwicine, isosandwicine, ajmaline, and isoajmaline, respectively.