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Synthesis 1988; 1988(3): 242-244
DOI: 10.1055/s-1988-27530
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A Novel Method for the Synthesis of 9-Benzyl-6-(2-methylhydrazino)purine and 1-Methyl-4-(2-methylhydrazino)-1H-pyrazolo[3,4-d]pyrimidine

Ramachandra S. Hosmane* , Benjamin B. Lim
  • *Laboratory for Chemical Dynamics, Department of Chemistry, University of Maryland Baltimore County, Catonsville, MD 21228, USA
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Publication Date:
20 August 2002 (online)

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A novel method for the synthesis of 9-benzyl-6-(2-methylhydrazino) purine (8a) and 1-methyl-4-(2-methylhydrazino)-1H-pyrazole [3,4-d]pyrimidine (8b) is reported. The method consists of reacting the formimidates of the corresponding 5-amino-4-cyanoimidazole and -pyrazole (i.e. 6a and 6b, respectively) with excess methylhydrazine catalyzed by trifluoroacetic acid. A tentative mechanism for the reaction is proposed.