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Synthesis 1987; 1987(12): 1133-1134
DOI: 10.1055/s-1987-28199
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Improved Conditions for the Formation of Tetrazoles

P. R. Bernstein* , E. P. Vacek
  • *Medicinal Chemistry Department, Stuart Pharmaceuticals, Division of ICI Americas Inc., Wilmington, DE 19897 U.S.A.
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Publication Date:
20 August 2002 (online)

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Tetrazoles can be prepared from nitriles and sodium azide in improved yield over shorter reaction time using triethylammonium chloride as the catalyst and 1-methyl-2-pyrrolidinone as the solvent.