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Synthesis 1987; 1987(8): 693-696
DOI: 10.1055/s-1987-28047
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Palladium-Catalyzed Coupling of Oxazol-2-yl- and 2-Oxazolin-2-yltrimethylstannanes with Aromatic Halides. A New Entry to 2-Aryl and 2-Heteroaryl Oxazoles and Oxazolines

Alessandro Dondoni* , Giancarlo Fantin, Marco Fogagnolo, Alessandro Medici, Paola Pedrini
  • *Departimento di Chimica, Laboratorio di Chimica Organica, Università di Ferrara, Ferrara, Italy
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Publication Date:
12 September 2002 (online)

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4-Methyloxazole and 4,4-dimethyl-2-oxazoline were treated with n-butyllithium and trimethyltin chloride to give the corresponding 2-trimethylstannyl derivatives which in the presence of tetrakis(triphenylphosphine)palladium(0) as a catalyst undergo cross-coupling reactions with various aryl and heteroaryl halides to give 2-aryl and 2-heteroaryl oxazoles and oxazolines in high yields.