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Synthesis 1987; 1987(1): 40-42
DOI: 10.1055/s-1987-27834
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Nickel-Catalyzed Synthesis of Arylacetonitriles from Arylzinc Chlorides and Bromoacetonitrile

Torbjörn Frejd* , Tomas Klingstedt
  • *Organic Chemistry 2 and Organic Chemistry 1, Chemical Center, PO Box 124, S-221 00, Lund, Sweden
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Publication Date:
20 August 2002 (online)

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Arylacetonitriles are synthesised by coupling arylzinc chlorides with bromoacetonitrile using Ni(acac)2/P(c-C6H11)(C6H5)2 as catalyst. The arylacetonitriles are reduced in situ with LiAlH4/AlCl3 to give the corresponding 2-aryl-1-aminoethanes