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Synthesis 1987; 1987(1): 33-35
DOI: 10.1055/s-1987-27831
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The Reactions of Benzylmalononitriles with Hydrazine and Hydroxylamine. Synthesis of Pyrazoles, Isoxazoles, and Pyrazolo[1,5-a]-pyrimidine Derivatives

Juan J. Vaquero* , Luis Fuentes, Juan C. Del Castillo, María I. Pérez, José L. García, José L. Soto
  • *Departamento de Química Orgánica, Universidad de Alcalá de Henares, Madrid, Spain
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Publication Date:
20 August 2002 (online)

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Benzylmalononitriles react with hydrazine or hydroxylamine to give 4-substituted 3,5-diaminopyrazoles or isoxazoles, respectively. Pyrazolo[1,5-a]pyrimidine derivatives are prepared by reaction of these pyrazoles with some 2,3-disubstituted propenenitriles (including benzylidenemalononitrile) under mild conditions.