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Synthesis 1986; 1986(6): 482-484
DOI: 10.1055/s-1986-31681
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A Mild, Convenient Preparation of N,N-Disubstituted Thioformamides From Secondary Amines

John E. Mills*
  • *McNeil Pharmaceutical, Spring House, Pennsylvania 19411, U. S. A.
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Publikationsdatum:
20. August 2002 (online)

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A number of N,N-disubstituted thioformamides can be conveniently prepared in good yield by heating the corresponding secondary amine at about 110°C with commercially available dimethylthioformamide. The reaction is sensitive to steric and electronic factors as evidenced by the failure of N-methylcyclohexanamine and N-methylbenzeneamine to react. Solid thioformamides often crystallize directly from the reaction in analytically pure form.