Download PDF
Synthesis 1986; 1986(3): 224-226
DOI: 10.1055/s-1986-31625
communication
© Georg Thieme Verlag, Rüdigerstr. 14, 70469 Stuttgart, Germany. All rights reserved. This journal, including all individual contributions and illustrations published therein, is legally protected by copyright for the duration of the copyright period. Any use, exploitation or commercialization outside the narrow limits set by copyright legislation, without the publisher's consent, is illegal and liable to criminal prosecution. This applies in particular to photostat reproduction, copying, cyclostyling, mimeographing or duplication of any kind, translating, preparation of microfilms, and electronic data processing and storage.

Substituted Benzotrichloride Synthesis by Phase Transfer-Catalyzed Chlorination

J. P. Chupp* , R. C. Grabiak, K. L. Leschinsky, T. L. Neumann
  • *Monsanto Agricultural Products Co., Research Department, St. Louis, Missouri 63167, U. S. A.
Further Information

Publication History

Publication Date:
20 August 2002 (online)

 PDF Download  Permissions and Reprints All articles of this category

A new method for converting benzyl and benzal chlorides to benzotrichlorides is reported. In contrast to prior art, the process involves contacting the substrates with strong alkali in a two-phase system containing phase transfer catalyst using organic soluble perchloralkanes acting upon base-generated carbanions. The method is particularly useful for preparing benzotrichlorides substituted by either alkyl or nitro groups.