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Synthesis 1985; 1985(12): 1148-1149
DOI: 10.1055/s-1985-31457
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A Novel Preparation of 5,6,7,8-Tetrahydroquinazolin-4(3H)-ones

Ferenc Fülöp* , Gábor Bernáth
  • *Institute of Pharmaceutical Chemistry, University Medical School, H-6720 Szeged, Eötvös u. 6, Hungary
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Publication Date:
27 September 2002 (online)

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Cyclocondensation of 2-oxocyclohexanecarboxamide with aldehydes and ammonia affords 4-oxo-1,2,5,6,7,8-hexahydroquinazolines which are conveniently dehydrogenated to the title compounds by treatment with palladium-on-carbon catalyst in boiling toluene.