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Synthesis 1985; 1985(12): 1104-1108
DOI: 10.1055/s-1985-31440
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General Cleavage of N-N and N-O Bonds Using Nickel/Aluminum Alloy

George Lunn* , Eric B. Sansone, Larry K. Keefer
  • *Environmental Control and Research Program, Program Resources, Inc., NCI-Frederick Cancer Research Facility, Frederick, Maryland 21 701-1013, U. S. A.
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Publication Date:
27 September 2002 (online)

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Addition of nickel/aluminum alloy to alkaline solutions of compounds containing N-N or N-O bonds appears to offer a general and convenient means for reducing such compounds to the corresponding amines. The method has been successfully applied to the reduction of nitrosamines, hydrazines, hydroxylamines, hydroxylamine ethers, triazenes, nitramines, N-oxides, tetrazenes, and nitroso, azo, and azoxy compounds.