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Synthesis 1985; 1985(10): 948-949
DOI: 10.1055/s-1985-31396
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An Efficient Synthesis of 1,3-Thiazole

L. Brandsma* , R. L. P. De Jong, H. D. Verkruijsse
  • *Department of Organic Chemistry of the State University, Croesestraat 79, NL-3522 AD Utrecht, The Netherlands
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Publication Date:
27 September 2002 (online)

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The cyclocondensation of methyl dithiocarbamate with chloroacetaldehyde in aqueous ethanol affords 2-methylthio-1,3-thiazole (82-88%) which is demethylsulfenylated to 1,3-thiazole (78-81%) by reaction with lithium in liquid ammonia followed by hydrolysis with aqueous ammonium chloride.