Download PDF
Synthesis 1972; 1972(9): 453-463
DOI: 10.1055/s-1972-21899
review
© Georg Thieme Verlag, Rüdigerstr. 14, 70469 Stuttgart, Germany. All rights reserved. This journal, including all individual contributions and illustrations published therein, is legally protected by copyright for the duration of the copyright period. Any use, exploitation or commercialization outside the narrow limits set by copyright legislation, without the publisher's consent, is illegal and liable to criminal prosecution. This applies in particular to photostat reproduction, copying, cyclostyling, mimeographing or duplication of any kind, translating, preparation of microfilms, and electronic data processing and storage.

Coupling Reagents in Peptide Synthesis

Yakir S. KLAUSNER* , Miklos BODANSKY
  • *Department of Chemistry, Case Western Reserve University, Cleveland, Ohio 44106
Further Information

Publication History

Publication Date:
12 September 2002 (online)

  PDF Download  Permissions and Reprints All articles of this category

The chemistry and scope of application of a series of reagents and reactions used for the formation of peptide bonds are discussed. They include: unsaturated ethers, dicyclohexylcarbodiimide, cyanamide, ketenimines, ketenes, ynamines, 1,2-oxazolium salts, EEDQ, acyloxyphosphonium salts, triphenylphosphite and imidazole, oxidation-reduction condensation, copper complexes, and silicon tetrachloride. 1. Unsaturated Ethers 1.1. α-Chlorovinyl Ethyl Ether, α,α-Dichlorodiethyl Ether, and Dichloromethyl Methyl Ether 1.2. Ethoxyacetylene 2. Dicyclohexylcarbodiimide 2.1. Dicyclohexylcarbodiimide and Additives 2.2. Complexes of DCC-Pentachlorophenol and DCC-Pentafluorophenol 3. Cyanamide 4. Ketenimines and Ketenes 5. Ynamines 6. 1,2-Oxazolium Salts 7. EEDQ 8. Acyloxyphosphonium Ions 9. Triphenylphosphite and Imidazole 10. Oxidation-Reduction Condensation 11. Copper(II) Complexes 12. Silicon Tetrachloride