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CC BY 4.0 · World J Nucl Med
DOI: 10.1055/s-0045-1813677
Case Report

Primary Large Cell Neuroendocrine Carcinoma of the Prostate Gland: An Uncommon Case

Authors

  • Margaret M. Mwania 

    1   Nuclear Medicine Division, Department of Radiology, Aga Khan University Hospital, Nairobi, Kenya

  • Dayib Buthul

    2   Department of Radiology, Aga Khan University Hospital, Nairobi, Kenya

  • Samuel Nguku

    1   Nuclear Medicine Division, Department of Radiology, Aga Khan University Hospital, Nairobi, Kenya

  • Khalid Makhdomi 

    1   Nuclear Medicine Division, Department of Radiology, Aga Khan University Hospital, Nairobi, Kenya
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Abstract

Primary large cell neuroendocrine prostate cancer is a rare and aggressive cancer commonly observed as a transformation of an already known prostate adenocarcinoma and on long-term androgen deprivation, although it can arise de novo. It has high potential for distant metastatic spread and is generally associated with poor survival compared to the classical adenocarcinoma type of prostate cancer. We present a case of an 83-year-old who had orchidectomy for treatment of metastatic prostate adenocarcinoma with normalization of prostate-specific antigen levels and subsequently developed recurrence with large cell neuroendocrine transformation.

Keywords

large cell - neuroendocrine - primary - prostate - carcinoma

Authors' Contributions

All authors contributed to the content, design, literature search, article preparation and writing, article editing, and article review. The article has been approved by all the authors. Each author believes that the article represents honest work.




Publication History

Article published online:
18 December 2025

© 2025. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution License, permitting unrestricted use, distribution, and reproduction so long as the original work is properly cited. (https://creativecommons.org/licenses/by/4.0/)

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