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CC BY 4.0 · Journal of Coloproctology 2025; 45(04): s00451812074
DOI: 10.1055/s-0045-1812074
Original Article

Topical Modalities to Reduce Acute Post-Hemorrhoidectomy Pain: A Comparative Clinical Study

Autor*innen

  • Yasser Ali Orban

    1   Department of General Surgery, Faculty of Human Medicine, Zagazig University, Zagazig, Sharqia, Egypt

  • Tarek Ezzat Abd Ellatif

    1   Department of General Surgery, Faculty of Human Medicine, Zagazig University, Zagazig, Sharqia, Egypt

  • Mohamed Ashraf Mohamed Ramez

    1   Department of General Surgery, Faculty of Human Medicine, Zagazig University, Zagazig, Sharqia, Egypt

  • Wo'oud Mohiedden Mohammad Abdelfattah

    2   Department of Anesthesia and Surgical Intensive Care, Faculty of Human Medicine, Zagazig University, Zagazig, Sharqia, Egypt

  • Reham Zakaria 

    1   Department of General Surgery, Faculty of Human Medicine, Zagazig University, Zagazig, Sharqia, Egypt

Funding The authors declare that they did not receive funding from agencies in the public, private, or non-profit sectors to conduct the present study.
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Abstract

Introduction

Despite the advances in pain therapy, postoperative hemorrhoidectomy pain is still common and annoying. The present study aims to minimize post-hemorrhoidectomy pain and improve the quality of life.

Materials and Methods

The current study is a single-center, prospective, randomized, comparative clinical trial performed in the General Surgery Department from January to October 2024. The study included 150 hemorrhoidectomy patients randomly allocated to five groups: group I – control group; group II – local injection of ketorolac and light bupivacaine; group III – injection of light bupivacaine; group IV – local injection of corticosteroids; and group V – topical diclofenac sodium gel.

Results

Compared ot the other groups, group IV presented significantly better outcomes (p < 0.001) regarding the need, dose, and frequency of nalufin, postoperative pain score, and time until first ambulation. However, it presented longer healing time than the other groups.

Conclusion

Local injections of corticosteroids can effectively reduce pain after hemorrhoidectomy.

Keywords

hemorrhoidectomy - pain - corticosteroids - bupivacaine - diclofenac sodium

Authors' Contributions

YAO: conceptualization, formal analysis, methodology, project administration, software, supervision, validation and writing – review & editing; MAMR: data curation, investigation and writing – original draft; WMM A: data curation and resources; RZ: data curation, formal analysis, resources, software, supervision, validation, writing – original draft and writing – review & editing; TEAE: methodology, project administration and visualization.


All authors read and approved of the final manuscript.


Data Availability

No datasets were generated or analyzed during the current study.


Ethical Approval

The present study was conducted following the ethical principles of the Declaration of Helsinki 2000, and it was approved by the Institutional Review Board (under number 40\14-Jan-2024), which provided an exemption for informed consent. Clinical Trial registration ID: (NCT06307106).




Publikationsverlauf

Eingereicht: 03. April 2025

Angenommen: 04. August 2025

Artikel online veröffentlicht:
29. Dezember 2025

© 2025. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution 4.0 International License, permitting copying and reproduction so long as the original work is given appropriate credit (https://creativecommons.org/licenses/by/4.0/)

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Bibliographical Record
Yasser Ali Orban, Tarek Ezzat Abd Ellatif, Mohamed Ashraf Mohamed Ramez, Wo'oud Mohiedden Mohammad Abdelfattah, Reham Zakaria. Topical Modalities to Reduce Acute Post-Hemorrhoidectomy Pain: A Comparative Clinical Study. Journal of Coloproctology 2025; 45: s00451812074.
DOI: 10.1055/s-0045-1812074