RSS-Feed abonnieren

DOI: 10.1055/s-0045-1811266
Secondary Analysis for Surveillance of Hepatitis C Virus Transmission from a Secondary-Level Hospital in Himachal Pradesh, India: A Brief Report
Autor*innen
Funding Not applicable.
Abstract
The National Viral Hepatitis Control Program (NVHCP) in India provides free diagnostic and therapeutic services. Analysis of secondary data under the program helps to understand about hepatitis and its associated risk factors. The present study was undertaken to analyze the secondary data (April 2023–December 2024) for hepatitis C virus (HCV) infection and associated factors at a secondary hospital in Himachal Pradesh, India. A total of 283 records were evaluated, where majority of the patients (69.6%) belonged to rural area. About half (52.0%) HCV-positive patients with mean hepatitis C viral load of 0.95 × 105 IU/mL were people who inject drugs (PWIDs). Additionally, PWIDs showed a high HCV positivity rate (63.1%). Odds of HCV infection was found to be significantly higher in males (odds ratio [OR]; 2.4; 95% CI: 1.2–4.7) and PWIDs (1.8; 95% CI: 1.1–3.0). Hepatitis C viral load among HCV-positive patients was not associated with gender, area (rural/urban), and PWID status. Occurrence of co-infection with human immunodeficiency virus (HIV) in HCV-positive PWIDs is also observed. Hence, there is a need to share information between NVHCP and National HIV/acquired immune deficiency syndrome Control Program for surveillance and formulation of public health interventions toward achieving elimination targets set by World Health Organization for 2030.
Ethical Approvals and Consent
This study is the outcome of retrospectively analyzed data maintained in our district hospital. Therefore, ethical approval and consent were not required.
Author Contributions
V.S. conceptualized the study, analyzed the data, and wrote the manuscript. M.M. helped in data collection and compilation. R.K. and S.M. critically revised the manuscript and provided administrative support. D.K. helped in data analysis, interpretation, and manuscript writing. All the authors read and approved the final version of manuscript.
Publikationsverlauf
Eingereicht: 13. Mai 2025
Angenommen: 28. Juli 2025
Artikel online veröffentlicht:
06. Oktober 2025
© 2025. Gastrointestinal Infection Society of India. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/)
Thieme Medical and Scientific Publishers Pvt. Ltd.
A-12, 2nd Floor, Sector 2, Noida-201301 UP, India
-
References
- 1 Li H-C, Lo S-Y. Hepatitis C virus: virology, diagnosis and treatment. World J Hepatol 2015; 7 (10) 1377-1389
- 2 Vineeta S, Kumar R, Sharma R. et al. Sociodemographic profile, genotype, and response to therapy in hepatitis C virus infection: a brief report from Himachal Pradesh. J Gastrointest Infect. 2023; 13 (01) 30-33
- 3 Rajkumar N, Khumukcham LS, Thangjam D. et al. Decentralised same day test and treatment of hepatitis C levering existing peer support networks among men who inject drugs: feasibility and effectiveness. Harm Reduct J 2024; 21 (01) 98
- 4 World Health Organization. Global Hepatitis Report 2024: Action for Access in Low- and Middle-Income Countries. Geneva: World Health Organization; 2024. xiv. 225
- 5 Pandey P, Roy A, Bhadoria AS. National viral hepatitis control program in India: Call for update. J Fam Med Prim Care 2023; 12 (09) 1755-1758
- 6 Anjali S, Kanwal S, Chavan A. Analysing factors responsible for transfusion transmitted infections (TTIs) among reactive blood donors in a blood centre of Himachal Pradesh (H. P.): a retrospective data analysis. Int J Sci Res 2023; 12 (06) 32-34
- 7 Cheema S, Rana V, Kulhari K, Yadav A, Sachdeva A. Prevalence of transfusion transmissible infections and associated factors among healthy blood donors in North Indian population – 4-year experience of licensed blood bank at tertiary care hospital. J Mar Med Soc 2022; 24 (01) 47-52
- 8 Verma K, Kumar S, Sharma V. Prevalence of hepatitis-C viral infection among opioid dependent injectable drug users: a study conducted at regional hospital drug de-addiction and treatment centre, Solan, Himachal Pradesh, India. Int J Res Med Sci 2020; 8 (07) 2458-2461
- 9 Xia X, Luo J, Bai J, Yu R. Epidemiology of hepatitis C virus infection among injection drug users in China: systematic review and meta-analysis. Public Health 2008; 122 (10) 990-1003
- 10 Burki T. WHO's 2024 global hepatitis report. Lancet Infect Dis 2024; 24 (06) e362-e363
- 11 Barranco MA, Rosenberg ES, Flanigan C. et al. A cross-sectional study of hepatitis C prevalence and correlates among persons who inject drugs in rural and non-rural communities. J Viral Hepat 2022; 29 (11) 994-1003
- 12 Sharma P, Satija M, Chaudhary A. et al. Epidemiological correlates of hepatitis C infection- a case control analysis from a tertiary care hospital. J Family Med Prim Care 2022; 11 (05) 2099-2105
- 13 Jordan AE, Perlman DC, Cleland CM, Wyka K, Schackman BR, Nash D. Community viral load and hepatitis C virus infection: community viral load measures to aid public health treatment efforts and program evaluation. J Clin Virol 2020; 124: 104285
- 14 Boodram B, Hershow RC, Cotler SJ, Ouellet LJ. Chronic hepatitis C virus infection and increases in viral load in a prospective cohort of young, HIV-uninfected injection drug users. Drug Alcohol Depend 2011; 119 (03) 166-171
- 15 Tanwar S, Rewari BB, Rao CD, Seguy N. India's HIV programme: successes and challenges. J Virus Erad 2016; 2 (Suppl4): 15-19
