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CC BY 4.0 · World J Nucl Med 2025; 24(04): 369-372
DOI: 10.1055/s-0045-1809053
Case Report

A Case of Lung Cancer Unexpectedly Detected with 99mTc (V)-DMSA Whole-Body/SPECT Imaging

Authors

  • Esmaeil Gharepapagh

    1   Clinical Research Development Unit of Tabriz Valiasr Hospital, Tabriz University of Medical Sciences, Tabriz, Iran
    2   Department of Nuclear Medicine, Medical School, Tabriz University of Medical Sciences, Tabriz, Iran

  • Leila Namvar

    3   Tuberculosis and Lung Disease Research Center, Tabriz University of Medical Sciences, Tabriz, Iran

  • Sahar Rezaei 

    1   Clinical Research Development Unit of Tabriz Valiasr Hospital, Tabriz University of Medical Sciences, Tabriz, Iran
    2   Department of Nuclear Medicine, Medical School, Tabriz University of Medical Sciences, Tabriz, Iran
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Abstract

In terms of cancer-related deaths, lung cancer is the most common type. To prevent this malignant and dangerous disease from progressing, early and differential diagnoses are very critical. A combination of dimercaptosuccinic acid and pentavalent 99mTc under alkaline conditions, 99mTc (V)-DMSA, can be used for malignant tumors' early diagnosis and prognosis. The 99mTc (V)-DMSA radiotracer is most commonly used for follow-up of medullary thyroid cancer metastases, but it is also successful in lung cancer and other malignancies. In this case, a 65-year-old woman with a recent history of nonproductive cough and mild dyspnea and suspicious small masses of lungs in computed tomography was selected for imaging with 99mTc (V)-DMSA to evaluate the condition of radiotracer uptake in the lung masses. The whole-body and single-photon emission computed tomography imaging with semiquantitative analysis showed abnormal uptakes in the lesions and the patient underwent to transbronchial biopsy and bronchial washing cytology that confirmed non-small cell lung cancer.

Keywords

lung cancer - 99mTc (V)-DMSA - SPECT imaging


Publication History

Article published online:
06 May 2025

© 2025. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution License, permitting unrestricted use, distribution, and reproduction so long as the original work is properly cited. (https://creativecommons.org/licenses/by/4.0/)

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