CC BY-NC-ND 4.0 · Sleep Sci
DOI: 10.1055/s-0045-1806953
Original Article

Predictors and Factors Associated with Insomnia in a Brazilian Sample: A Cross-Sectional Study

Isabela Mayumi Nishino Aizawa
1   Department of Psychiatry, University of São Paulo, São Paulo, Brazil
,
2   Department of Psychology and Education, Faculty of Social and Human Sciences, University of Beira Interior, Covilhã, Portugal
,
Helder Sergio Lira Soares Filho
1   Department of Psychiatry, University of São Paulo, São Paulo, Brazil
,
Rosa Hasan
3   Ambulatório do Sono, Hospital das Clínicas, University of São Paulo, São Paulo, Brazil
,
Andrea Cecilia Toscanini
3   Ambulatório do Sono, Hospital das Clínicas, University of São Paulo, São Paulo, Brazil
,
Renatha El Rafihi-Ferreira
1   Department of Psychiatry, University of São Paulo, São Paulo, Brazil
4   Department of Clinical Psychology, University of São Paulo, São Paulo, Brazil
› Author Affiliations
Funding Source Isabela Mayumi Nishino Aizawa and Renatha El Rafihi-Ferreira received research support from Fundação de Amparo à Pesquisa do Estado de São Paulo – FAPESP under grant numbers 23/03073-0 and 2018/19506-5, respectively].

Abstract

Objective

Chronic insomnia is associated with various functional and mental health impairments. The present study aimed to evaluate variables potentially associated with insomnia in a Brazilian sample.

Materials and Methods

The study was conducted in a psychiatric hospital of a public medical school in the city of São Paulo, Brazil. The sample included 1,435 adults with a mean age of 38.3 years. Participants were divided into two groups: one with individuals diagnosed with insomnia (according to the Diagnostic and Statistical Manual of Mental Disorders, 5th edition and the Insomnia Severity Index) and a comparison group without the diagnosis. The Hospital Anxiety and Depression Scale (HADS) was used to assess psychopathological variables (anxiety and depression) and sociodemographic and anthropometric questionnaires to provide further characterization of the sample. Multivariable binary logistic regression analyses were performed.

Results

Male sex and lacking a university degree were associated with increased odds of insomnia, with average increases of 1.93 and 1.89, respectively. Each additional year of age and each additional point on the depression and anxiety increased the likelihood of insomnia by averages of 1.05, 1.18, and 1.40, respectively.

Conclusion

This study provides evidence of associations between biopsychosocial factors and insomnia, suggesting the potential for developing preventive and treatment protocols for this condition.



Publication History

Received: 09 April 2024

Accepted: 17 February 2025

Article published online:
22 April 2025

© 2025. Brazilian Sleep Academy. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/)

Thieme Revinter Publicações Ltda.
Rua Rego Freitas, 175, loja 1, República, São Paulo, SP, CEP 01220-010, Brazil

 
  • References

  • 1 American Psychiatric Association (APA). Manual diagnóstico e estatístico de transtornos mentais: DSM -5 -TR. 5, texto revisado. Porto Alegre: Artmed Editora LTDA; 2023
  • 2 Hashim H, Ng JS, Ngo JX, Ng YZ, Aravindkumar B. Lifestyle factors associated with poor sleep quality among undergraduate dental students at a Malaysian private university. Sleep Sci 2022; 15 (04) 399-406
  • 3 Islam Z, Hsan K, Islam S, Gozal D, Hossain M. Assessment of sleep quality and its association with problematic internet use among university students: a cross-sectional investigation in Bangladesh. Sleep Sci 2021; 14 (Spec 1): 8-15
  • 4 Morin CM, Jarrin DC. Epidemiology of Insomnia: Prevalence, Course, Risk Factors, and Public Health Burden. Sleep Med Clin 2022; 17 (02) 173-191
  • 5 Bollu PC, Kaur H. Insomnia and Sleep. Mo Med 2019; 116 (01) 68-75
  • 6 Araújo MFS, Souza TA, Medeiros AA, Souza JC, Barbosa IR. Factors associated with sleep problems and sleeping pill use in Brazilians. Rev Saude Publica 2022; 56: 68
  • 7 Brazilian Institute of Geography and Statistics. National Health Survey (PNS 2019): perception of health status, lifestyles, chronic diseases and oral health: Brazil and major regions. IBGE, Work and Income Coordination. [uptodate 2019; cited 2024 Jan 19]. Available from: https://www.ibge.gov.br/estatisticas/sociais/saude/9160-pesquisa-nacional-de-saude.html
  • 8 Gajardo YZ, Ramos JN, Muraro AP, Moreira NF, Ferreira MG, Rodrigues PRM. Problemas com o sono e fatores associados na população brasileira: Pesquisa Nacional de Saúde, 2013. Cien Saude Colet 2021; 26 (02) 601-610
  • 9 Castro LS, Poyares D, Leger D, Bittencourt L, Tufik S. Objective prevalence of insomnia in the São Paulo, Brazil epidemiologic sleep study. Ann Neurol 2013; 74 (04) 537-546
  • 10 El Rafihi-Ferreira R, do Brasil do Carmo MMI, Bassolli L, Hasan R, Aizawa IMN, Toscanini AC. Cognitive and psychological factors associated with severe insomnia in Brazilian women: a cross-sectional study. Psicol Reflex Crit 2022; 35 (01) 39
  • 11 Peng YT, Hsu YH, Chou MY, Chu C-S, Su C-S, Liang C-K. et al. Factors associated with insomnia in older adult outpatients vary by gender: a cross-sectional study. BMC Geriatr 2021; 21 (01) 681
  • 12 Zeng LN, Zong QQ, Yang Y, Zhang L, Xiang Y-F, Ng CH. et al. Gender Difference in the Prevalence of Insomnia: A Meta-Analysis of Observational Studies. Front Psychiatry 2020; 11: 577429
  • 13 Lloyd-Jones DM, Allen NB, Anderson CAM, Black T, Brewer LC, Foraker RE. et al; American Heart Association. Life's Essential 8: Updating and Enhancing the American Heart Association's Construct of Cardiovascular Health: A Presidential Advisory From the American Heart Association. Circulation 2022; 146 (05) e18-e43
  • 14 Javaheri S, Barbe F, Campos-Rodriguez F, Dempsey JA, Khayat R, Javaheri S. et al. Sleep Apnea: Types, Mechanisms, and Clinical Cardiovascular Consequences. J Am Coll Cardiol 2017; 69 (07) 841-858
  • 15 Jackson CL, Walker JR, Brown MK, Das R, Jones NL. A workshop report on the causes and consequences of sleep health disparities. Sleep 2020; 43 (08) zsaa037
  • 16 McCracken LM, Badinlou F, Buhrman M, Brocki KC. Psychological impact of COVID-19 in the Swedish population: Depression, anxiety, and insomnia and their associations to risk and vulnerability factors. Eur Psychiatry 2020; 63 (01) e81
  • 17 de Oliveira MPB, de Castro AEF, Miri AL, Lima CR, Truax BD, Probst VS. et al. The impact of the COVID-19 pandemic on neuropsychiatric and sleep disorders, and quality of life in individuals with neurodegenerative and demyelinating diseases: a systematic review and meta-analysis of observational studies. BMC Neurol 2023; 23 (01) 150
  • 18 Lancee J, Effting M, van der Zweerde T, van Daal L, van Straten A, Kamphuis JH. Cognitive processes mediate the effects of insomnia treatment: evidence from a randomized wait-list controlled trial. Sleep Med 2019; 54: 86-93
  • 19 Youngstedt SD, Ito W, Passos GS, Santana MG, Youngstedt JM. Testing the sleep hygiene recommendation against nighttime exercise. Sleep Breath 2021; 25 (04) 2189-2196
  • 20 McGovney KD, Curtis AF, McCrae CS. Associations between objective afternoon and evening physical activity and objective sleep in patients with fibromyalgia and insomnia. J Sleep Res 2021; 30 (01) e13220
  • 21 Kawata Y, Maeda M, Sato T, Maruyama K, Wada H, Ikeda A, Tanigawa T. Association between marital status and insomnia-related symptoms: findings from a population-based survey in Japan. Eur J Public Health 2020; 30 (01) 144-149
  • 22 Marthinsen GN, Helseth S, Småstuen M, Bjorvatn B, Bandlien SM, Fegran L. Sleep patterns and psychosocial health of parents of preterm and full-born infants: a prospective, comparative, longitudinal feasibility study. BMC Pregnancy Childbirth 2022; 22 (01) 546
  • 23 Roskam I, Mikolajczak M. Gender differences in the nature, antecedents and consequences of parental burnout. Sex Roles 2020; 83 (7-8): 485-498
  • 24 Staner L. Comorbidity of insomnia and depression. Sleep Med Rev 2010; 14 (01) 35-46
  • 25 Stuck BA, Maurer JT, Schlarb AA, Schredl M, Weeß H. Practice of sleep medicine: Sleep disorders in children and adults. Switzerland: Springer; 2021: 77-109
  • 26 Morin CM, Belleville G, Bélanger L, Ivers H. The Insomnia Severity Index: psychometric indicators to detect insomnia cases and evaluate treatment response. Sleep 2011; 34 (05) 601-608
  • 27 Taylor DJ, Wilkerson A, Pruiksma KE, Dietch JR, Wardle-Pinkston S. 2019 Structured clinical interview for sleep disorders-revised (SCISD-R). Retrieved from: https://insomnia.arizona.edu/SCISD
  • 28 Morin CM. Insomnia: Psychological assessment and management. New York: Guilford Press; 1993
  • 29 Castro LS. Adaptação e validação do Índice de Gravidade de Insônia (IGI) [Dissertação de Mestrado]. São Paulo: Universidade Federal de São Paulo; 2011
  • 30 Zigmond AS, Snaith RP. The hospital anxiety and depression scale. Acta Psychiatr Scand 1983; 67 (06) 361-370
  • 31 Botega NJ, Bio MR, Zomignani MA, Garcia Jr C, Pereira WAB. Transtornos do humor em enfermaria de clínica médica e validação de escala de medida (HAD) de ansiedade e depressão. Rev Saude Publica 1995; 29 (05) 355-363
  • 32 James G, Witten D, Hastie T, Tibshirani R. An introduction to statistical learning: with applications in R. New York: Springer; 2013: 205-259
  • 33 Tjur T. Coefficients of Determination in Logistic Regression Models. A New Proposal: The Coefficient of Discrimination. Am Stat 2009; 63 (04) 366-372
  • 34 Brewster GS, Riegel B, Gehrman PR. Insomnia in the Older Adult. Sleep Med Clin 2022; 17 (02) 233-239
  • 35 Patel D, Steinberg J, Patel P. Insomnia in the Elderly: A Review. J Clin Sleep Med 2018; 14 (06) 1017-1024
  • 36 Sexton CE, Sykara K, Karageorgiou E, Zitser J, Rosa T, Yaffe K, Leng Y. Connections between insomnia and cognitive aging. Neurosci Bull 2020; 36 (01) 77-84
  • 37 Liu RM. Aging, cellular senescence, and Alzheimer's disease. Int J Mol Sci 2022; 23 (04) 1989
  • 38 Rosso AL, Studenski SA, Chen WG, Aizenstein HJ, Alexander NB, Bennett DA. et al. Aging, the central nervous system, and mobility. J Gerontol A Biol Sci Med Sci 2013; 68 (11) 1379-1386
  • 39 Kostin A, Alam MA, McGinty D, Alam MN. Adult hypothalamic neurogenesis and sleep-wake dysfunction in aging. Sleep 2021; 44 (02) 173
  • 40 da Costa Santos EC, Dórea FS, de Souza SR, da Silva GM, Santos ACS, de Andrade AFSM. et al. Evidências científicas das barreiras e ações à saúde do homem no contexto da Atenção Primária. Revista Eletrônica Acervo Saúde 2022; 15 (09) e10926
  • 41 Atumane AMA. Aspectos socioculturais relacionados à saúde do homem. São Paulo: Dialética; 2022
  • 42 Jansson-Fröjmark M, Lindblom K. A bidirectional relationship between anxiety and depression, and insomnia? A prospective study in the general population. J Psychosom Res 2008; 64 (04) 443-449
  • 43 Choueiry N, Salamoun T, Jabbour H, El Osta N, Hajj A, Rabbaa Khabbaz L. Insomnia and Relationship with Anxiety in University Students: A Cross-Sectional Designed Study. PLoS One 2016; 11 (02) e0149643
  • 44 Ramsawh HJ, Stein MB, Belik SL, Jacobi F, Sareen J. Relationship of anxiety disorders, sleep quality, and functional impairment in a community sample. J Psychiatr Res 2009; 43 (10) 926-933
  • 45 Serdari A, Manolis A, Tsiptsios D, Vorvolakos T, Terzoudi A, Nena E. et al. Insight into the relationship between sleep characteristics and anxiety: A cross-sectional study in indigenous and minority populations in northeastern Greece. Psychiatry Res 2020; 292: 113361
  • 46 Batterham PJ, Glozier N, Christensen H. Sleep disturbance, personality and the onset of depression and anxiety: prospective cohort study. Aust N Z J Psychiatry 2012; 46 (11) 1089-1098
  • 47 Seow LSE, Verma SK, Mok YM, Kumar S, Chang S, Satghare P. et al. Evaluating DSM-5 Insomnia Disorder and the Treatment of Sleep Problems in a Psychiatric Population. J Clin Sleep Med 2018; 14 (02) 237-244
  • 48 Nutt D, Wilson S, Paterson L. Sleep disorders as core symptoms of depression. Dialogues Clin Neurosci 2008; 10 (03) 329-336
  • 49 Fang H, Tu S, Sheng J, Shao A. Depression in sleep disturbance: A review on a bidirectional relationship, mechanisms and treatment. J Cell Mol Med 2019; 23 (04) 2324-2332
  • 50 Sutton DA, Moldofsky H, Badley EM. Insomnia and health problems in Canadians. Sleep 2001; 24 (06) 665-670
  • 51 Dollander M. [Etiology of adult insomnia]. Encefalo 2002; 28 (6 Pt 1): 493-502
  • 52 Kim Y, Ramos AR, Carver CS, Ting A, Hahn K, Mossavar-Rahmani Y. et al. Marital Status and Gender Associated with Sleep Health among Hispanics/Latinos in the US: Results from HCHS/SOL and Sueño Ancillary Studies. Behav Sleep Med 2022; 20 (05) 531-542
  • 53 Zreik G, Asraf K, Haimov I, Tikotzky L. Maternal insomnia and depressive symptoms and early childhood sleep among Arab and Jewish families in Israel. Sleep Med 2022; 100: 262-268
  • 54 Hirotsu C, Bittencourt L, Garbuio S, Andersen ML, Tufik S. Sleep complaints in the Brazilian population: Impact of socioeconomic factors. Sleep Sci 2014; 7 (03) 135-142
  • 55 Rocha FL, Guerra HL, Lima-Costa MF. Prevalence of insomnia and associated socio-demographic factors in a Brazilian community: the Bambuí study. Sleep Med 2002; 3 (02) 121-126
  • 56 Ribeiro TF. Gentrificação: aspectos conceituais e práticos de sua verificação no Brasil. Revista de Direito da Cidade 2018; 10 (03) 1334-1356
  • 57 Slovic AD, Tomasiello DB, Giannotti M, Andrade Mde Fatima, Nardocci AC. The long road to achieving equity: Job accessibility restrictions and overlapping inequalities in the city of São Paulo. J Transp Geogr 2019; 78: 181-193
  • 58 Hayes BL, Vabistsevits M, Martin RM, Lawlor DA, Richmond RC, Robinson T. Establishing causal relationships between sleep and adiposity traits using Mendelian randomization. Obesity (Silver Spring) 2023; 31 (03) 861-870
  • 59 Rodrigues GD, Fiorelli EM, Furlan L, Montano N, Tobaldini E. Obesity and sleep disturbances: The “chicken or the egg” question. Eur J Intern Med 2021; 92: 11-16
  • 60 Sayre GM. The costs of insecurity: Pay volatility and health outcomes. J Appl Psychol 2023; 108 (07) 1223-1243
  • 61 Wong WS, Fielding R. Prevalence of insomnia among Chinese adults in Hong Kong: a population-based study. J Sleep Res 2011; 20 (1 Pt 1): 117-126
  • 62 Riemann D, Krone LB, Wulff K, Nissen C. Sleep, insomnia, and depression. Neuropsychopharmacology 2020; 45 (01) 74-89
  • 63 El Rafihi-Ferreira R, Morin CM, Toscanini AC, Lotufo F, Brasil IS, Gallinaro JG. et al. Acceptance and commitment therapy-based behavioral intervention for insomnia: a pilot randomized controlled trial. Br J Psychiatry 2021; 43 (05) 504-509
  • 64 El Rafihi-Ferreira R, Morin CM, Hasan R, Brasil IS, Ribeiro JHZ, Cecília Toscanini A. A pilot randomized controlled trial (RCT) of acceptance and commitment therapy versus cognitive behavioral therapy for chronic insomnia. Behav Sleep Med 2023; 21 (02) 193-207