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CC BY-NC-ND 4.0 · South Asian J Cancer 2024; 13(04): 305-308
DOI: 10.1055/s-0045-1802333
Review Article
Etiology

Familial Polyposis and Colon Cancer

Amit Kumar Jain
1   Department of Medical Oncology, Jain Hospital, Bengaluru, Karnataka, India
,
Purvish M. Parikh
2   Department of Clinical Hematology, Sri Ram Cancer Center, Mahatma Gandhi University of Medical Sciences and Technology, Jaipur, India
,
Subash Chandra Dadhich
3   Department of Laparoscopic Surgery, Arogya Hospital, Vizag, Andhra Pradesh, India
,
Anil Arora
4   Department of Gastroenterology, Sir Ganga Ram Hospital, New Delhi, India
,
Mandhir Kumar
4   Department of Gastroenterology, Sir Ganga Ram Hospital, New Delhi, India
,
Piyush Ranjan
4   Department of Gastroenterology, Sir Ganga Ram Hospital, New Delhi, India
,
Naresh Kumar Bansal
4   Department of Gastroenterology, Sir Ganga Ram Hospital, New Delhi, India
,
Praveen Sharma
4   Department of Gastroenterology, Sir Ganga Ram Hospital, New Delhi, India
,
Shyam Aggarwal
5   Department of Medical Oncology, Sir Ganga Ram Hospital, New Delhi, India
,
C. Selvasekar
4   Department of Gastroenterology, Sir Ganga Ram Hospital, New Delhi, India
,
Saumitra Rawat
6   Department of Surgical Gastroenterology, SGRH, New Delhi, India
› Author Affiliations Funding None.
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Abstract

Familial adenomatous polyposis is an important hereditary risk factor for colon cancer. Such patients and families need special attention for prevention, early detection, and optimal treatment. Molecular testing is key to identify the specific mutation in the proband and can then make it easier to identify other family members at risk. Aggressive surveillance and colonoscopy will be indicated in most patients. Both colonic and extra-colonic manifestations are important. Chemoprevention is worth considering. Almost all patients will ultimately need colectomy. These details will be discussed in this review.

Keywords

hereditary - risk - premalignant lesion


Publication History

Article published online:
28 January 2025

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