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CC BY-NC-ND 4.0 · Sleep Sci
DOI: 10.1055/s-0045-1802321
Review Article

Unlocking Mysteries: Exploring the Dynamic Interplay among Sleep, the Immune System, and Curcumin in Contemporary Research

Rohit Kumar   #
1   Department of Biotechnology, Sri Ramaswamy Memorial (SRM) University, Sonipat, Haryana, India
,
Atul Pandey    #
2   Department of Ecology and Evolutionary Biology, College of Literature, Science, and the Arts, University of Michigan, Ann Arbor, MI, United States
3   Department of Entomology, Martin-Gatton College of Agriculture, Food and Environment, University of Kentucky, Lexington, KY, United States
,
Arpana Vibhuti
1   Department of Biotechnology, Sri Ramaswamy Memorial (SRM) University, Sonipat, Haryana, India
,
Manzoor Ali
4   Genomics and Genome Biology Unit, Council of Scientific and Industrial Research, Institute of Genomics and Integrative Biology, Delhi, India
5   Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, Uttar Pradesh, India
,
Chung-Ming Chang
6   Chang Gung University, Guishan Dist, Taoyuan City, Taiwan
7   Department of Medical Biotechnology and Laboratory Science, College of Medicine, Chang Gung University, Guishan Dist, Taoyuan City, Taiwan
8   Laboratory Animal Center, Chang Gung University, Guishan Dist, Taoyuan City, Taiwan
,
Ramendra Pati Pandey 
1   Department of Biotechnology, Sri Ramaswamy Memorial (SRM) University, Sonipat, Haryana, India
9   School of Health Sciences and Technology, University of Petroleum and Energy Studies (UPES), Dehradun, Uttarakhand, India
› Institutsangaben Funding Source The authors declare that they did not receive funding from agencies in the public, private, or non-profit sectors to conduct the present study.
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Abstract

The scientific disciplines encompassing sleep, the immune system, and curcumin have garnered considerable interest due to their interconnectedness and potential implications for human health. Sleep is a crucial factor in maintaining optimal immune function, as it facilitates the release of cytokines, which are signaling molecules responsible for regulating immune responses. On the contrary, sleep deprivation has the potential of inhibiting immune function, thereby heightening the susceptibility to infection and disease. Curcumin, a naturally occurring polyphenol derived from the turmeric plant, has been observed to possess immunomodulatory characteristics through its ability to modulate the equilibrium between pro- and anti-inflammatory cytokines. It is worth noting that there is evidence suggesting that curcumin supplementation could enhance the quality of sleep. Scientific studies have indicated that curcumin supplementation has been associated with an increase in the duration of sleep and a decrease in wakefulness among individuals who are in good health. Additionally, curcumin supplementation has been found to enhance sleep quality and alleviate symptoms of depression in individuals diagnosed with major depressive disorder. The intricate interplay among sleep, the immune system, and curcumin is multifaceted, and scientific investigations indicate that curcumin may serve as a beneficial dietary adjunct to enhance immune function and optimize sleep quality. Nevertheless, additional investigation is required to fully comprehend the mechanisms through which curcumin alters the immune system and enhances sleep, as well as to ascertain the most effective dose and timing of curcumin supplementation.

Keywords

sleep loss - cytokines - curcumin - REM sleep - NREM sleep - neuro-inflammation

Authors' Contributions

RK, AP, RPP: Writing-review and editing, supervision, conceptualization. AV, MA: writing-review and editing. All authors have read and agreed regarding the version of the manuscript submitted for publication.


# The authors have contributed equally.




Publikationsverlauf

Eingereicht: 10. Mai 2024

Angenommen: 28. Oktober 2024

Artikel online veröffentlicht:
27. März 2025

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