Subscribe to RSS
DOI: 10.1055/s-0044-1788933
Catheter-Directed Therapies for Deep Vein Thrombosis and Pulmonary Embolism: Nationwide Trends in Medicare Part B Patients from 2015 to 2021
Abstract
Background Nationwide trends in the utilization of catheter-directed therapies for deep vein thrombosis and pulmonary embolism in the Medicare population are essential as they represent a major health care challenge. The annual incidence and mortality with venous thromboembolism are around 900,000 and 60,000 to 100,000 patients, respectively, in the United States.
Methods Data were acquired from the Data.CMS.gov website on Physician/Supplier Procedure Summary with a list of Medicare Part B fee-for-service claims from 2015 to 2021. Current Procedural Terminology codes 37187 (percutaneous venous mechanical thrombectomy) and 37212 (thrombolytic venous therapy) were queried for deep vein thrombosis. Similarly, Current Procedural Terminology codes 37184 (percutaneous arterial mechanical thrombectomy) and 37211 (thrombolytic arterial therapy) were queried for pulmonary embolism. Annual procedure counts, site of service, and self-reported specialty of the operator were recorded.
Results Overall, there was a trend toward increasing utilization of thrombectomy and decreasing utilization of thrombolysis procedures for both deep vein thrombosis and pulmonary embolism. Radiologists performed the majority of the catheter-directed therapy interventions for deep vein thrombosis, while radiologists and surgeons performed a similar number of catheter-directed therapy procedures for pulmonary embolism. Cardiologists were third in the catheter-directed therapy procedure count for both deep vein thrombosis and pulmonary embolism.
Conclusion An analysis of nationwide trends from 2015 to 2021 suggests increasing utilization of thrombectomy starting in 2020 when compared to thrombolysis for catheter-directed therapies for both deep vein thrombosis and pulmonary embolism procedures. Newer thrombectomy technologies may be one of the drivers of this shift from thrombolysis to thrombectomy.
Keywords
catheter-directed therapy - deep vein thrombosis - pulmonary embolism - thrombectomy - thrombolysisData Availability Statement
The datasets generated and/or analyzed during the current study are available in the Data.CMS.gov repository, the Medicare database website Physician/Supplier Procedure Summary - Centers for Medicare & Medicaid Services Data (cms.gov). The authors take complete responsibility for the accuracy of the data analysis.
Authors' Contribution
A.G.T. contributed to the design of the project and data acquisition, drafted and revised the manuscript, and gave final approval of the submitted version. O.S.A. contributed to the conception and design of the project, supervision of data acquisition and data analysis, critical revision of the manuscript, and final approval of the submitted version. Q.Y. and D.K. contributed to critical revision of the manuscript and final approval of the submitted version. M.V.P. contributed to conception and design of the project, supervision of data acquisition and data analysis, critical revision of the manuscript, and final approval of the submitted version.
Publication History
Article published online:
18 September 2024
© 2024. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution License, permitting unrestricted use, distribution, and reproduction so long as the original work is properly cited. (https://creativecommons.org/licenses/by/4.0/)
Thieme Medical and Scientific Publishers Pvt. Ltd.
A-12, 2nd Floor, Sector 2, Noida-201301 UP, India
-
References
- 1 Centers for Disease Control and Prevention (CDC). Data and Statistics on Venous Thromboembolism. Atlanta, GA: CDC; 2023
- 2 Kearon C, Kahn SR, Agnelli G, Goldhaber S, Raskob GE, Comerota AJ. Antithrombotic therapy for venous thromboembolic disease: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines (8th Edition). Chest 2008; 133 (6, Suppl): 454S-545S
- 3 Heit JA, Lahr BD, Petterson TM, Bailey KR, Ashrani AA, Melton III LJ. Heparin and warfarin anticoagulation intensity as predictors of recurrence after deep vein thrombosis or pulmonary embolism: a population-based cohort study. Blood 2011; 118 (18) 4992-4999
- 4 Sista AK, Miller LE, Kahn SR, Kline JA. Persistent right ventricular dysfunction, functional capacity limitation, exercise intolerance, and quality of life impairment following pulmonary embolism: systematic review with meta-analysis. Vasc Med 2017; 22 (01) 37-43
- 5 Karthikesalingam A, Young EL, Hinchliffe RJ, Loftus IM, Thompson MM, Holt PJ. A systematic review of percutaneous mechanical thrombectomy in the treatment of deep venous thrombosis. Eur J Vasc Endovasc Surg 2011; 41 (04) 554-565
- 6 Thukral S, Salter A, Lancia S, Kahn SR, Vedantham S. Predictors of clinical outcomes of pharmacomechanical catheter-directed thrombolysis for acute iliofemoral deep vein thrombosis: analysis of a multicenter randomized trial. J Vasc Interv Radiol 2022; 33 (10) 1161-1170.e11
- 7 Semaan DB, Phillips AR, Reitz K. et al. Improved long-term outcomes with catheter-directed therapies over medical management in patients with submassive pulmonary embolism-a retrospective matched cohort study. J Vasc Surg Venous Lymphat Disord 2023; 11 (01) 70-81
- 8 Vedantham S, Goldhaber SZ, Julian JA. et al; ATTRACT Trial Investigators. Pharmacomechanical catheter-directed thrombolysis for deep-vein thrombosis. N Engl J Med 2017; 377 (23) 2240-2252
- 9 Benarroch-Gampel J, Pujari A, Aizpuru M, Rajani RR, Jordan WD, Crawford R. Technical success and short-term outcomes after treatment of lower extremity deep vein thrombosis with the ClotTriever system: a preliminary experience. J Vasc Surg Venous Lymphat Disord 2020; 8 (02) 174-181
- 10 Tu T, Toma C, Tapson VF. et al; FLARE Investigators. A prospective, single-arm, multicenter trial of catheter-directed mechanical thrombectomy for intermediate-risk acute pulmonary embolism: the FLARE study. JACC Cardiovasc Interv 2019; 12 (09) 859-869
- 11 O'Sullivan GJ. Thrombolysis versus thrombectomy in acute deep vein thrombosis. Interv Cardiol 2011; 3 (05) 589-596
- 12 Vedantham S. Thrombectomy and thrombolysis for the prevention and treatment of postthrombotic syndrome. Hematology (Am Soc Hematol Educ Program) 2017; 2017 (01) 681-685
- 13 Lichtenberg MKW, Stahlhoff S, Młyńczak K. et al. Endovascular mechanical thrombectomy versus thrombolysis in patients with iliofemoral deep vein thrombosis: a systematic review and meta-analysis. Vasa 2021; 50 (01) 59-67
- 14 Von Ende E, Gayou EL, Chick JFB, Makary MS. Nationwide trends in catheter-directed therapy utilization for the treatment of lower extremity deep vein thrombosis in Medicare beneficiaries. J Vasc Interv Radiol 2021; 32 (11) 1576-1582.e1
- 15 Gayou EL, Makary MS, Hughes DR. et al. Nationwide trends in use of catheter-directed therapy for treatment of pulmonary embolism in Medicare beneficiaries from 2004 to 2016. J Vasc Interv Radiol 2019; 30 (06) 801-806