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CC BY 4.0 · Journal of Child Science 2024; 14(01): e19-e23
DOI: 10.1055/s-0044-1787681
Original Article

A Long-Term Follow-up Study of Asthmatic Children Discontinued Allergen-Specific Immunotherapy

Yana Huang
1   Department of Pediatrics, Dazhou Central Hospital, Dazhou, Sichuan, People's Republic of China
,
Ying Huang
2   Department of Respiratory Disease, Children's hospital of Chongqing Medical University, Chongqing, People's Republic of China
,
Jie Li
3   Department of Clinical Research Center, Dazhou Central Hospital, Dazhou, Sichuan, People's Republic of China
,
Benjin Zhang
1   Department of Pediatrics, Dazhou Central Hospital, Dazhou, Sichuan, People's Republic of China
› Author Affiliations Funding This study was supported by the scientific fund of Health Commission of Sichuan Province (18PJ040) and Sichuan University-Dazhou Municipal People's Government Strategic Cooperation Special Fund Project (2020CDDZ-23).
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Abstract

Our objective was to explore the factors associated with the prognosis of allergic asthmatic children with poor compliance with subcutaneous immunotherapy (SCIT). A telephonic follow-up was conducted in 616 asthmatic children who received SCIT treatment from June 2005 to October 2010. The status of asthmatic controlled was based on their level of asthma symptom control when they were followed-up. Seven factors, including sex, age, family history of allergic disease, severity of mite allergy, times of SCIT, whether inhaled corticosteroids regularly, and with rhinitis or not, were analyzed. In total, 322 asthmatic children discontinued the 3-year course of SCIT. Of the 127 children included in the final analysis, 85 (66.9%) were asthmatic controlled patients and 42 (33.1%) were asthmatic uncontrolled patients. The median (interquartile range) age of the 127 asthmatic children was 7.1 ± 4.8 years. The proportion of male and female was 87/40. In the seven factors, family history of allergic diseases (p = 0.035), whether inhaling corticosteroids regularly (p = 0.007), were significantly related to the level of asthma symptom control, whereas the age of these asthmatic children, severity of mite allergy, times of SCIT, and asthma with rhinitis or not had no relation to the level of asthma symptom control. Our findings revealed that the family history of allergic diseases was an important factor affecting the prognosis of childhood asthma, and inhaling corticosteroids regularly after discontinuing SCIT could significantly improve their prognosis. These results could provide value in clinical asthma treatment.

Keywords

asthma - subcutaneous immunotherapy - compliance - follow-up - risk factors

Authors' Contributions

Y.H. and B.Z. conceived and designed the experiments, performed the data analysis, prepared figures and/or tables, and authored or reviewed drafts of the paper. Y.H. collected data and analyzed the data. J.L. authored or reviewed drafts of the paper. All authors approved the final draft. We have no conflict of interest.


Supplementary Material



Publication History

Received: 17 August 2023

Accepted: 19 November 2023

Article published online:
21 June 2024

© 2024. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution License, permitting unrestricted use, distribution, and reproduction so long as the original work is properly cited. (https://creativecommons.org/licenses/by/4.0/)

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