The Role of Electroencephalography in the Prediction of Relapse of Febrile Convulsion in Patients Aged between 6 to 60 Months: A Prospective Cohort Study

Masoud Hassanvand Amouzadeh; Mohsen Mollamohammadi; Mohammad Reza Razavi; Mojgan Dianat; Amir Hamta; Hadi Zamanian; Mohammad Amin Habibi

doi:10.1055/s-0044-1787191

Journal of Pediatric Neurology, Inhaltsverzeichnis

Journal of Pediatric Neurology 2024; 22(06): 450-456
DOI: 10.1055/s-0044-1787191

Original Article

The Role of Electroencephalography in the Prediction of Relapse of Febrile Convulsion in Patients Aged between 6 to 60 Months: A Prospective Cohort Study

Masoud Hassanvand Amouzadeh

¹Neuroscience Research Center, Qom University of Medical Sciences, Qom, Iran

,

Mohsen Mollamohammadi

²Division of Pediatric Neurology, Department of Pediatrics, School of Medicine, Qom University of Medical Sciences, Qom, Iran

,

Mohammad Reza Razavi

²Division of Pediatric Neurology, Department of Pediatrics, School of Medicine, Qom University of Medical Sciences, Qom, Iran

,

Mojgan Dianat

³Department of Pediatrics, Hazrat-e Fateme Masoume Hospital, Qom University of Medical Sciences, Qom, Iran

,

Amir Hamta

⁴Department of Biostatistics, School of Medicine, Arak University of Medical Sciences, Arak, Iran

,

Hadi Zamanian

⁵Department of Health Education and Promotion, School of Health, Qom University of Medical Sciences, Qom, Iran

,

Mohammad Amin Habibi

⁶Student Research Committee, Faculty of Medicine, Qom University of Medical Sciences, Qom, Iran

› Institutsangaben

Abstract

Febrile seizures (FS) are the most common type of seizure in pediatrics, and patients with FS can present with recurrent febrile seizures (RFS). Some clinical factors have been known to predict RFS, but there is no consensus regarding electroencephalography (EEG). We aimed to determine the ability of EEG to predict RFS. This prospective cohort study was done in children aged between 6 and 60 months. The EEG was performed on patients 2 weeks after the FS, and the patients were followed up for 6 months. Two hundred patients were enrolled. Recurrence of febrile convulsion occurred in 27% of the patients. A higher risk of recurrent seizures was seen in females compared with males (p = 0.04, hazard ratio [HR] = 1.83), children with a family history of seizure (p = 0.011, HR = 2), people with fever-to-seizure interval <1 hour (p = 0.009, HR = 6.1), as well as 1 to 24 hours interval between fever and seizure (p = 0.033, HR = 2.15), aEnd patients with abnormal EEG findings compared with normal EEG (p = 0.001, HR = 4.45). There was no significant relationship between RFS and other studied factors. This study showed the ability of EEG to predict RFS, and the results showed a higher likelihood of recurrence occurring in subjects with abnormal rather than normal EEG.

Keywords

febrile seizure - epilepsy - electroencephalography - recurrent febrile seizure - predictive factors

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References
1 Harini C, Nagarajan E, Kimia AA. et al. Utility of initial EEG in first complex febrile seizure. Epilepsy Behav 2015; 52 (Pt A): 200-204
2 Subcommittee on Febrile Seizures, American Academy of Pediatrics. Neurodiagnostic evaluation of the child with a simple febrile seizure. Pediatrics 2011; 127 (02) 389-394
3 Carapetian S, Hageman J, Lyons E. et al. Emergency department evaluation and management of children with simple febrile seizures. Clin Pediatr (Phila) 2015; 54 (10) 992-998
4 Aguirre-Velázquez C, Huerta Hurtado AM, Ceja-Moreno H. et al. Clinical guideline. Febrile seizures, diagnosis and treatment. Revista Mexicana Neurociencia 2019; 20 (02) 42-48
5 Maytal J, Shinnar S. Febrile status epilepticus. Pediatrics 1990; 86 (04) 611-616
6 Vestergaard M, Pedersen CB, Sidenius P, Olsen J, Christensen J. The long-term risk of epilepsy after febrile seizures in susceptible subgroups. Am J Epidemiol 2007; 165 (08) 911-918
7 Farasati Far B, Behnoush AH, Ghondaghsaz E, Habibi MA, Khalaji A. The interplay between vitamin C and thyroid. Endocrinol Diabetes Metab 2023; 6 (04) e432
8 Kumar N, Midha T, Rao YK. Risk factors of recurrence of febrile seizures in children in a tertiary care hospital in Kanpur: a one year follow up study. Ann Indian Acad Neurol 2019; 22 (01) 31-36
9 Sofijanov N, Emoto S, Kuturec M. et al. Febrile seizures: clinical characteristics and initial EEG. Epilepsia 1992; 33 (01) 52-57
10 Habibi MA, Aghaei F, Tajabadi Z, Mirjani MS, Minaee P, Eazi S. The performance of machine learning for prediction of H3K27 M mutation in midline gliomas: a systematic review and meta-analysis. World Neurosurg 2024; 186: e7-e19
11 Habibi MA, Amani H, Mirjani MS, Molla A. Predicting the radiological outcome of cerebral aneurysm treatment with machine learning algorithms; a systematic review and diagnostic meta-analysis. Interdiscip Neurosurg 2024; 36: 101929
12 Wo SB, Lee JH, Lee YJ, Sung T-J, Lee KH, Kim SK. Risk for developing epilepsy and epileptiform discharges on EEG in patients with febrile seizures. Brain Dev 2013; 35 (04) 307-311
13 Habibi MA, Fakhfouri A, Mirjani MS. et al. Prediction of cerebral aneurysm rupture risk by machine learning algorithms: a systematic review and meta-analysis of 18,670 participants. Neurosurg Rev 2024; 47 (01) 34
14 von Elm E, Altman DG, Egger M, Pocock SJ, Gøtzsche PC, Vandenbroucke JP. STROBE Initiative. The Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) statement: guidelines for reporting observational studies. Ann Intern Med 2007; 147 (08) 573-577
15 Neligan A, Bell GS, Giavasi C. et al. Long-term risk of developing epilepsy after febrile seizures: a prospective cohort study. Article Neurology 2012; 78 (15) 1166-1170
16 Krumholz A, Wiebe S, Gronseth GS. et al. Evidence-based guideline: management of an unprovoked first seizure in adults: report of the Guideline Development Subcommittee of the American Academy of Neurology and the American Epilepsy Society. Neurology 2015; 84 (16) 1705-1713
17 Gencpinar P, Yavuz H, Bozkurt Ö, Haspolat Ş, Duman Ö. The risk of subsequent epilepsy in children with febrile seizure after 5 years of age. Seizure 2017; 53: 62-65
18 Kuturec M, Emoto SE, Sofijanov N. et al. Febrile seizures: is the EEG a useful predictor of recurrences?. Clin Pediatr (Phila) 1997; 36 (01) 31-36
19 Provisional Committee on Quality Improvement SoFS. Practice parameter: the neurodiagnostic evaluation of the child with a first simple febrile seizure. American Academy of Pediatrics. Provisional Committee on Quality Improvement, Subcommittee on Febrile Seizures. Pediatrics 1996; 97 (05) 769-772
20 Hirtz D, Ashwal S, Berg A. et al. Practice parameter: evaluating a first nonfebrile seizure in children: report of the quality standards subcommittee of the American Academy of Neurology, The Child Neurology Society, and The American Epilepsy Society. Neurology 2000; 55 (05) 616-623
21 Habibi MA, Alesaeidi S, Zahedi M, Hakimi Rahmani S, Piri SM, Tavakolpour S. The efficacy and safety of rituximab in ANCA-associated vasculitis: a systematic review. Biology (Basel) 2022; 11 (12) 1767
22 Paybast S, Habibi MA, Naser Moghadasi A. Characteristics and management of multiple sclerosis patients during the Omicron era: is there a concern about the MS course in the face of the new variant of COVID-19?. Neurol Sci 2023; 44 (02) 659-665
23 Joshi C, Wawrykow T, Patrick J, Prasad A. Do clinical variables predict an abnormal EEG in patients with complex febrile seizures?. Seizure 2005; 14 (06) 429-434
24 Abouei Mehrizi MA, Habibi MA, Keykhosravi E, Eazi SM, Minaee P, Mirjani MS. The safety and efficacy of eCLIPs for treatment of wide-necked bifurcation aneurysms: a systematic review and meta-analysis. World Neurosurg 2023; 180: 213-223.e7
25 Shafiee H, Riahipour F, Hormati A. et al. Comparison of the sedative effect of ketamine, magnesium sulfate, and propofol in patients undergoing upper gastrointestinal endoscopy: double-blinded randomized clinical trial. CNS Neurol Disord Drug Targets 2022; 22 (08) 1259-1266
26 Sabaei M, Rahimian S. Haj Mohamad Ebrahim Ketabforoush A, et al. Salivary levels of disease-related biomarkers in the early stages of Parkinson's and Alzheimer's disease: A cross-sectional study. IBRO Neurosci Rep 2023; 14: 285-292
27 Shahidi R, Baradaran M, Asgarzadeh A. et al. Diagnostic performance of MRI radiomics for classification of Alzheimer's disease, mild cognitive impairment, and normal subjects: a systematic review and meta-analysis. Aging Clin Exp Res 2023; 35 (11) 2333-2348
28 Kubota J, Higurashi N, Hirano D. et al. Predictors of recurrent febrile seizures during the same febrile illness in children with febrile seizures. J Neurol Sci 2020; 411: 116682
29 Berg AT, Shinnar S, Darefsky AS. et al. Predictors of recurrent febrile seizures. A prospective cohort study. Arch Pediatr Adolesc Med 1997; 151 (04) 371-378
30 Cappellari AM, Brizio C, Mazzoni MB. et al. Predictive value of EEG for febrile seizure recurrence. Brain Dev 2018; 40 (04) 311-315
31 Choudhari PR, Lowden A, Dolce A. Exploring the age-old question: what is the predictive value of eeg for future epilepsy in children with complex febrile seizures?. J Child Neurol 2023; 38 (05) 290-297
32 Gradisnik P, Zagradisnik B, Palfy M, Kokalj-Vokac N, Marcun-Varda N. Predictive value of paroxysmal EEG abnormalities for future epilepsy in focal febrile seizures. Brain Dev 2015; 37 (09) 868-873
33 Pavlidou E, Panteliadis C. Prognostic factors for subsequent epilepsy in children with febrile seizures. Epilepsia 2013; 54 (12) 2101-2107
34 Karimzadeh P, Rezayi A, Togha M. et al. The best time for EEG recording in febrile seizure. Iran J Child Neurol 2014; 8 (01) 20-25
35 Natsume J, Hamano SI, Iyoda K. et al. New guidelines for management of febrile seizures in Japan. Brain Dev 2017; 39 (01) 2-9
36 Schomer DL, Lopes da Silva F. Niedermeyer's Electroencephalography: Basic Principles, Clinical Applications, and Related Fields. Baltimore: Williams and Wilkins; 1999
37 Dilber B, Yıldız N, Kamaşak T. et al. Pseudo-petit mal discharge: a marker of favorable prognosis in febrile seizure. Archives of Epilepsy 2022; 28 (01) 18-22