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CC BY-NC-ND 4.0 · Indian J Radiol Imaging 2024; 34(04): 670-676
DOI: 10.1055/s-0044-1786828
Systematic Review

Outcome of Transjugular Intrahepatic Portosystemic Shunt in Patients with Cirrhosis and Refractory Hepatic Hydrothorax: A Systematic Review and Meta-analysis

Authors

  • Suprabhat Giri 

    1   Department of Gastroenterology and Hepatology, Kalinga Institute of Medical Sciences, Bhubaneswar, Odisha, India

  • Ranjan Kumar Patel 

    2   Department of Radiodiagnosis, All India Institute of Medical Sciences, Bhubaneswar, Odisha, India

  • Taraprasad Tripathy 

    2   Department of Radiodiagnosis, All India Institute of Medical Sciences, Bhubaneswar, Odisha, India

  • Mansi Chaudhary

    3   Department of Gastroenterology, All India Institute of Medical Sciences, Bhubaneswar, Odisha, India

  • Prajna Anirvan

    4   Kalinga Gastroenterology Foundation, Cuttack, Odisha, India

  • Swati Chauhan

    5   Department of Medicine, Bharati Vidyapeeth's Medical College, Pune, Maharashtra, India

  • Mitali Madhumita Rath

    6   Department of Pathology, IMS & SUM II Medical College and Hospital, Bhubaneswar, Odisha, India

  • Manas Kumar Panigrahi

    3   Department of Gastroenterology, All India Institute of Medical Sciences, Bhubaneswar, Odisha, India
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Abstract

Background Around 5% of patients with cirrhosis of the liver develop hepatic hydrothorax (HH). For patients with refractory HH (RHH), transjugular intrahepatic portosystemic shunt (TIPS) has been investigated in small studies. Hence, the present meta-analysis aimed to summarize the current data on the outcome of TIPS in patients with RHH.

Methods From inception through June 2023, MEDLINE, Embase, and Scopus were searched for studies analyzing the outcome of TIPS in RHH. Clinical response, adverse events (AEs), mortality, and shunt dysfunction were the primary outcomes assessed. The event rates with their 95% confidence interval were calculated using a random-effects model.

Results A total of 12 studies (n = 466) were included in the final analysis. The pooled complete and partial response rates were 47.2% (35.8–58.5%) and 25.5% (16.7–34.3%), respectively. The pooled incidences of serious AEs and post-TIPS liver failure after TIPS in RHH were 5.6% (2.1–9.0%) and 7.6% (3.1–12.1%), respectively. The pooled incidences of overall hepatic encephalopathy (HE) and severe HE nonresponsive to standard treatment after TIPS in RHH were 33.2% (20.0–46.4%) and 3.6% (0.4–6.8%), respectively. The pooled 1-month and 1-year mortality rates were 14.0% (8.3–19.6%) and 42.0% (33.5–50.4%), respectively. The pooled incidence of shunt dysfunction after TIPS in RHH was 24.2% (16.3–32.2%).

Conclusion RHH has a modest response to TIPS in patients with cirrhosis, with only half having a complete response. Further studies are required to ascertain whether early TIPS can improve the outcome of patients with cirrhosis and HH.

Keywords

portal hypertension - cirrhosis - pleural effusion - hepatic hydrothorax - transjugular intrahepatic portosystemic shunt

Supplementary Material



Publication History

Article published online:
18 May 2024

© 2024. Indian Radiological Association. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/)

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