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Semin Reprod Med 2024; 42(01): 015-024
DOI: 10.1055/s-0044-1786732
Review Article

The Role of Anti-Müllerian Hormone in Ovarian Function

Sena Yildiz
1   Department of Internal Medicine, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands
,
Loes M.E. Moolhuijsen 
1   Department of Internal Medicine, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands
,
Jenny A. Visser 
1   Department of Internal Medicine, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands
› Author Affiliations Financial Support No funding was received.
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Abstract

Anti-Müllerian hormone (AMH) is a member of the transforming growth factor β (TGFβ) superfamily, whose actions are restricted to the endocrine-reproductive system. Initially known for its role in male sex differentiation, AMH plays a role in the ovary, acting as a gatekeeper in folliculogenesis by regulating the rate of recruitment and growth of follicles. In the ovary, AMH is predominantly expressed by granulosa cells of preantral and antral follicles (i.e., post primordial follicle recruitment and prior to follicle-stimulating hormone (FSH) selection). AMH signals through a BMP-like signaling pathway in a manner distinct from other TGFβ family members. In this review, the latest insights in AMH processing, signaling, its regulation of spatial and temporal expression pattern, and functioning in folliculogenesis are summarized. In addition, effects of AMH variants on ovarian function are reviewed.

Keywords

anti-Müllerian hormone - folliculogenesis - signaling - genetics


Publication History

Article published online:
23 May 2024

© 2024. Thieme. All rights reserved.

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