Semin Musculoskelet Radiol 2024; 28(03): 337-351
DOI: 10.1055/s-0044-1785471
Review Article

Advanced Imaging of Gout and Other Inflammatory Diseases Around the Knee

1   Department of Radiology, National Institute of Geriatrics, Rheumatology and Rehabilitation, Warsaw, Poland
,
1   Department of Radiology, National Institute of Geriatrics, Rheumatology and Rehabilitation, Warsaw, Poland
,
2   Department of Radiology, Nuffield Orthopaedic Centre, Oxford University Hospitals NHS Trust, Oxford, United Kingdom
,
3   Department of Radiology, Charité - Universitätsmedizin Berlin, Campus Mitte, Humboldt-Universität zu Berlin, Freie Universität Berlin, Berlin, Germany
,
4   Department of Cardiac, Thoracic, Vascular Sciences and Public Health – DCTV, University of Padova, Padova, Italy
,
2   Department of Radiology, Nuffield Orthopaedic Centre, Oxford University Hospitals NHS Trust, Oxford, United Kingdom
› Author Affiliations

Abstract

The knee is one of the most commonly affected joints in the course of inflammatory arthropathies, such as crystal-induced and autoimmune inflammatory arthritis. The latter group includes systemic connective tissue diseases and spondyloarthropathies. The different pathogenesis of these entities results in their varied radiologic images. Some lead quickly to joint destruction, others only after many years, and in the remaining, destruction will not be a distinguishing radiologic feature.

Radiography, ultrasonography, and magnetic resonance imaging have traditionally been the primary modalities in the diagnosis of noninflammatory and inflammatory arthropathies. In the case of crystallopathies, dual-energy computed tomography has been introduced. Hybrid techniques also offer new diagnostic opportunities. In this article, we discuss the pathologic findings and imaging correlations for crystallopathies and inflammatory diseases of the knee, with an emphasis on recent advances in their imaging diagnosis.



Publication History

Article published online:
20 May 2024

© 2024. Thieme. All rights reserved.

Thieme Medical Publishers, Inc.
333 Seventh Avenue, 18th Floor, New York, NY 10001, USA

 
  • References

  • 1 Sudoł-Szopińska I, Herregods N, Doria AS. et al. Advances in musculoskeletal imaging in juvenile idiopathic arthritis. Biomedicines 2022; 10 (10) 2417
  • 2 Gitto S, Messina C, Vitale N, Albano D, Sconfienza LM. Quantitative musculoskeletal ultrasound. Semin Musculoskelet Radiol 2020; 24 (04) 367-374
  • 3 Sudoł-Szopińska I, Jurik AG, Eshed I. et al. Recommendations of the ESSR Arthritis Subcommittee for the use of magnetic resonance imaging in musculoskeletal rheumatic diseases. Semin Musculoskelet Radiol 2015; 19 (04) 396-411
  • 4 Mourad C, Cosentino A, Nicod Lalonde M, Omoumi P. Advances in bone marrow imaging: strengths and limitations from a clinical perspective. Semin Musculoskelet Radiol 2023; 27 (01) 3-21
  • 5 Giraudo C, Lecouvet FE, Cotten A. et al. Whole-body magnetic resonance imaging in inflammatory diseases: Where are we now? Results of an International Survey by the European Society of Musculoskeletal Radiology. Eur J Radiol 2021; 136: 109533
  • 6 Giraudo C, Kainberger F, Boesen M, Trattnig S. Quantitative imaging in inflammatory arthritis: between tradition and innovation. Semin Musculoskelet Radiol 2020; 24 (04) 337-354
  • 7 Vo Chieu VD, Vo Chieu V, Dressler F. et al. Juvenile idiopathic arthritis of the knee: is contrast needed to score disease activity when using an augmented MRI protocol comprising PD-weighted sequences?. Eur Radiol 2023; 33 (05) 3775-3784
  • 8 Barendregt AM, van Gulik EC, Groot PFC. et al. Prolonged time between intravenous contrast administration and image acquisition results in increased synovial thickness at magnetic resonance imaging in patients with juvenile idiopathic arthritis. Pediatr Radiol 2019; 49 (05) 638-645
  • 9 Boesen M, Kubassova O, Sudoł-Szopińska I. et al. MR imaging of joint infection and inflammation with emphasis on dynamic contrast-enhanced MR imaging. PET Clin 2018; 13 (04) 523-550
  • 10 Ezzati F, Chalian M, Pezeshk P. 3D MRI of the rheumatic diseases. Semin Musculoskelet Radiol 2021; 25 (03) 425-432
  • 11 Altahawi F, Pierce J, Aslan M, Li X, Winalski CS, Subhas N. 3D MRI of the knee. Semin Musculoskelet Radiol 2021; 25 (03) 455-467
  • 12 Sudoł-Szopińska I, Cotten A, Teh J. Foot and ankle inflammatory arthritis. In: Davies M, James S, Botchu R. eds. Medical Radiology. Diagnostic Imaging. Imaging of the Foot & Ankle: Techniques and Applications. 2nd ed. Cham, Switzerland: Springer; 2023: 355-390
  • 13 Shang J, Li XH, Lu SQ, Shang Y, Li LL, Liu B. Gout of feet and ankles in different disease durations: diagnostic value of single-source DECT and evaluation of urate deposition with a novel semi-quantitative DECT scoring system. Adv Rheumatol 2021; 61 (01) 36
  • 14 Diekhoff T, Kiefer T, Stroux A. et al. Detection and characterization of crystal suspensions using single-source dual-energy computed tomography: a phantom model of crystal arthropathies. Invest Radiol 2015; 50 (04) 255-260
  • 15 Kotlyarov M, Hermann KGA, Mews J, Hamm B, Diekhoff T. Development and validation of a quantitative method for estimation of the urate burden in patients with gouty arthritis using dual-energy computed tomography. Eur Radiol 2020; 30 (01) 404-412
  • 16 Rajiah P, Sundaram M, Subhas N. Dual-energy CT in musculoskeletal imaging: what is the role beyond gout?. AJR Am J Roentgenol 2019; 213 (03) 493-505
  • 17 Ziegeler K, Hermann S, Hermann KGA, Hamm B, Diekhoff T. Dual-energy CT in the differentiation of crystal depositions of the wrist: does it have added value?. Skeletal Radiol 2020; 49 (05) 707-713
  • 18 Caballero Motta LR, Anzola Alfaro AM, Janta I. et al. Radiosynovectomy in routine care: an old tool with modern applications. Ther Adv Musculoskelet Dis 2021; 13: X211055309
  • 19 Gholamrezanezhad A, Basques K, Batouli A, Matcuk G, Alavi A, Jadvar H. Clinical nononcologic applications of PET/CT and PET/MRI in musculoskeletal, orthopedic, and rheumatologic imaging. AJR Am J Roentgenol 2018; 210 (06) W245-W263
  • 20 Mallinson PI, Reagan AC, Coupal T, Munk PL, Ouellette H, Nicolaou S. The distribution of urate deposition within the extremities in gout: a review of 148 dual-energy CT cases. Skeletal Radiol 2014; 43 (03) 277-281
  • 21 Benjamin M, McGonagle D. The enthesis organ concept and its relevance to the spondyloarthropathies. Adv Exp Med Biol 2009; 649: 57-70
  • 22 Pracoń G, Aparisi Gómez MP, Simoni P, Gietka P, Sudoł-Szopińska I. Conventional radiography and ultrasound imaging of rheumatic diseases affecting the pediatric population. Semin Musculoskelet Radiol 2021; 25 (01) 68-81
  • 23 Dubash SR, De Marco G, Wakefield RJ, Tan AL, McGonagle D, Marzo-Ortega H. Ultrasound imaging in psoriatic arthritis: what have we learnt in the last five years?. Front Med (Lausanne) 2020; 7: 487
  • 24 Sudoł-Szopińska I, Kontny E, Zaniewicz-Kaniewska K, Prohorec-Sobieszek M, Saied F, Maśliński W. Role of inflammatory factors and adipose tissue in pathogenesis of rheumatoid arthritis and osteoarthritis. Part I: Rheumatoid adipose tissue. J Ultrason 2013; 13 (53) 192-201
  • 25 Michalski E, Ostrowska M, Gietka P, Sudoł-Szopińska I. Magnetic resonance imaging of the knee joint in juvenile idiopathic arthritis. Reumatologia 2020; 58 (06) 416-423
  • 26 Sudoł-Szopińska I, Afonso PD, Jacobson JA, Teh J. Imaging of gout: findings and pitfalls. A pictorial review. Acta Reumatol Port 2020; 45 (01) 20-25
  • 27 Sotniczuk M, Nowakowska-Płaza A, Wroński J, Wisłowska M, Sudoł-Szopińska I. The clinical utility of dual-energy computed tomography in the diagnosis of gout—a cross-sectional study. J Clin Med 2022; 11 (17) 5249
  • 28 Lee YHGG, Song GG. Diagnostic accuracy of ultrasound in patients with gout: a meta-analysis. Semin Arthritis Rheum 2018; 47 (05) 703-709
  • 29 Gamala M, Jacobs JWG, van Laar JM. The diagnostic performance of dual energy CT for diagnosing gout: a systematic literature review and meta-analysis. Rheumatology (Oxford) 2019; 58 (12) 2117-2121
  • 30 Stauder SK, Peloso PM. Dual-energy computed tomography has additional prognostic value over clinical measures in gout including tophi: a systematic literature review. J Rheumatol 2022; 49 (11) 1256-1268
  • 31 Zhang B, Yang M, Wang H. Diagnostic value of ultrasound versus dual-energy computed tomography in patients with different stages of acute gouty arthritis. Clin Rheumatol 2020; 39 (05) 1649-1653
  • 32 Diekhoff T, Kotlyarov M, Mews J, Hamm B, Hermann KGA. Iterative reconstruction may improve diagnosis of gout: an ex vivo (bio)phantom dual-energy computed tomography study. Invest Radiol 2018; 53 (01) 6-12
  • 33 Kotlyarov M, Mews J, Ulas ST, Ziegeler K, Hamm B, Diekhoff T. Influence of contrast medium on tophus detection using dual-energy CT: phantom study and clinical illustration. Eur Radiol Exp 2023; 7 (01) 43
  • 34 Colebatch AN, Edwards CJ, Østergaard M. et al. EULAR recommendations for the use of imaging of the joints in the clinical management of rheumatoid arthritis. Ann Rheum Dis 2013; 72 (06) 804-814
  • 35 Karasick D. Imaging of rheumatoid arthritis. In: Weissman BN. ed. Imaging of Arthritis and Metabolic Bone Disease. Philadelphia, PA: Saunders Elsevier;; 2009: 340-364
  • 36 Ostrowska M, Maśliński W, Prochorec-Sobieszek M, Nieciecki M, Sudoł-Szopińska I. Cartilage and bone damage in rheumatoid arthritis. Reumatologia 2018; 56 (02) 111-120
  • 37 Kondo Y, Suzuki K, Inoue Y. et al. Significant association between joint ultrasonographic parameters and synovial inflammatory factors in rheumatoid arthritis. Arthritis Res Ther 2019; 21 (01) 14
  • 38 Meng XH, Wang Z, Zhang XN, Xu J, Hu YC. Rheumatoid arthritis of knee joints: MRI-pathological correlation. Orthop Surg 2018; 10 (03) 247-254
  • 39 Chaplin DM. The pattern of bone and cartilage damage in the rheumatoid knee. J Bone Joint Surg Br 1971; 53 (04) 711-717
  • 40 Kimura C, Vainio K. The pattern of meniscus damage in the rheumatoid arthritis. Arch Orthop Unfallchir 1975; 83 (02) 145-151
  • 41 Salaffi F, Carotti M, Poliseno AC. et al. Quantification of sarcopenia in patients with rheumatoid arthritis by measuring the cross-sectional area of the thigh muscles with magnetic resonance imaging. Radiol Med (Torino) 2023; 128 (05) 578-587
  • 42 Yang JH, Kwon HH, Lee JK, Bang SY, Lee HS. Successful arthroscopic treatment of refractory and complicated popliteal cyst associated with rheumatoid arthritis in combination with osteoarthritis: case series and literature review. Rheumatol Int 2019; 39 (12) 2177-2183
  • 43 Resnick D, Kransdorf MJ. Rheumatoid arthritis and related diseases. In: Resnick D, Kransdorf MJ. eds. Bone and Joint Imaging. Philadelphia, PA: Saunders Elsevier; 2005: 209-254
  • 44 Brown AK. How to interpret plain radiographs in clinical practice. Best Pract Res Clin Rheumatol 2013; 27 (02) 249-269
  • 45 Sudoł-Szopińska I, Zaniewicz-Kaniewska K, Saied F, Kunisz W, Smorawińska P, Włodkowska-Korytkowska M. The role of ultrasonography in the diagnosis of rheumatoid arthritis and peripheral spondyloarthropathies. Pol J Radiol 2014; 79: 59-63
  • 46 Tom S, Zhong Y, Cook R, Aydin SZ, Kaeley G, Eder L. Development of a preliminary ultrasonographic enthesitis score in psoriatic arthritis—GRAPPA ultrasound working group. J Rheumatol 2019; 46 (04) 384-390
  • 47 Sudoł-Szopińska I, Kwiatkowska B, Kołodziejczak M. Musculoskeletal extraintestinal manifestations during the course of non-specific bowel diseases. Pol Przegl Chir 2013; 85 (11) 669-675
  • 48 Jacques T, Sudoł-Szopińska I, Larkman N, O'Connor P, Cotten A. Musculoskeletal manifestations of non-RA connective tissue diseases: scleroderma, systemic lupus erythematosus, Still's disease, dermatomyositis/polymyositis, Sjögren's syndrome, and mixed connective tissue disease. Semin Musculoskelet Radiol 2018; 22 (02) 166-179
  • 49 Fodor D, Rodriguez-Garcia SC, Cantisani V. et al. The EFSUMB guidelines and recommendations for musculoskeletal ultrasound. Part I: Extra-articular pathologies. Ultraschall Med 2022; 43 (01) 34-57
  • 50 Sudoł-Szopińska I, Jacques T, Gietka P, Cotten A. Imaging in dermatomyositis in adults and children. J Ultrason 2020; 20 (80) e36-e42
  • 51 Idzior M, Sotniczuk M, Michalski E, Gietka P, Sudoł-Szopińska I. Ultrasonography, MRI and classic radiography of skin and MSK involvement in juvenile scleroderma. J Ultrason 2021; 20 (83) e311-e317
  • 52 Krusche M, Schneider U, Diekhoff T. Calcinosis universalis in systemic sclerosis. Dtsch Arztebl Int 2021; 118 (07) 115
  • 53 Freire V, Becce F, Feydy A. et al. MDCT imaging of calcinosis in systemic sclerosis. Clin Radiol 2013; 68 (03) 302-309
  • 54 Elahmar H, Feldman BM, Johnson SR. Management of calcinosis cutis in rheumatic diseases. J Rheumatol 2022; 49 (09) 980-989
  • 55 Shimizu H, Nishioka H. 18F-FDG PET-CT in adult-onset Still's disease. BMJ Case Rep 2021; 14 (03) e242717
  • 56 Jurik AG, Klicman RF, Simoni P, Robinson P, Teh J. SAPHO and CRMO: the value of imaging. Semin Musculoskelet Radiol 2018; 22 (02) 207-224
  • 57 Rubenstein J. Seronegative spondyloarthropathies and SAPHO syndrome. In: Weissman BN. ed. Imaging of Arthritis and Metabolic Bone Disease. Philadelphia, PA:: Saunders Elsevier; 2009: 410-427
  • 58 Rakieh C, Nam JL, Hunt L. et al. Predicting the development of clinical arthritis in anti-CCP positive individuals with non-specific musculoskeletal symptoms: a prospective observational cohort study. Ann Rheum Dis 2015; 74 (09) 1659-1666 DOI: 10.1136/annrheumdis-2014-205227.
  • 59 Jaremko JL, Jeffery D, Buller M. et al. Preliminary validation of the Knee Inflammation MRI Scoring System (KIMRISS) for grading bone marrow lesions in osteoarthritis of the knee: data from the Osteoarthritis Initiative. Ann Rheum Dis 2015; 74 (06) 1156-1163