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CC BY 4.0 · Chinese medicine and natural products 2024; 04(01): e1-e7
DOI: 10.1055/s-0044-1782159
Review Article

The Research Progress of the Application of Bioinformatics in the Diagnosis and Treatment of Alzheimer's Disease

Zhiyang Yu
1   Academy of Chinese Medical Sciences, Henan University of Chinese Medicine, Zhengzhou, Henan, China
,
Wenpan Wang
1   Academy of Chinese Medical Sciences, Henan University of Chinese Medicine, Zhengzhou, Henan, China
,
Qiong Qiao
1   Academy of Chinese Medical Sciences, Henan University of Chinese Medicine, Zhengzhou, Henan, China
,
Yiran Sun
1   Academy of Chinese Medical Sciences, Henan University of Chinese Medicine, Zhengzhou, Henan, China
2   Collaborative Innovation Center of Research and Development on the Whole Industry Chain of Yu-Yao, Henan Province, Zhengzhou, Henan, China
,
Zhishen Xie
1   Academy of Chinese Medical Sciences, Henan University of Chinese Medicine, Zhengzhou, Henan, China
2   Collaborative Innovation Center of Research and Development on the Whole Industry Chain of Yu-Yao, Henan Province, Zhengzhou, Henan, China
,
Junying Song
1   Academy of Chinese Medical Sciences, Henan University of Chinese Medicine, Zhengzhou, Henan, China
2   Collaborative Innovation Center of Research and Development on the Whole Industry Chain of Yu-Yao, Henan Province, Zhengzhou, Henan, China
,
Zhenqiang Zhang
1   Academy of Chinese Medical Sciences, Henan University of Chinese Medicine, Zhengzhou, Henan, China
2   Collaborative Innovation Center of Research and Development on the Whole Industry Chain of Yu-Yao, Henan Province, Zhengzhou, Henan, China
,
Huifen Ma
1   Academy of Chinese Medical Sciences, Henan University of Chinese Medicine, Zhengzhou, Henan, China
2   Collaborative Innovation Center of Research and Development on the Whole Industry Chain of Yu-Yao, Henan Province, Zhengzhou, Henan, China
› Author Affiliations Funding This work was supported by the National Natural Science Foundation of China (82305087, 82274612), General Project of China Postdoctoral Science Foundation (2022M711080), and Key Research and Development Program of Henan Province (231111312900).
› Further Information
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Abstract

Alzheimer's disease (AD) is characterized by a complex pathogenesis, limited diagnostic methods, and a lack of effective therapeutic drugs in clinical settings, posing significant challenges in modern medical research. Bioinformatics offers new perspectives for identifying key pathological biomarkers of AD, analyzing differentially expressed genes in AD, screening for effective drug targets against AD, studying the mechanisms of AD pathogenesis, and discovering novel anti-AD drugs. However, data preprocessing and statistical analysis methods in bioinformatics research can significantly impact results, and there is a lack of consistency and coordination in analysis methods across platforms and laboratories in practical studies, making it difficult to compare data between studies. Therefore, it is crucial to establish standardized operating procedures and quality control protocols, improve the reproducibility of methods across platforms, and promote data comparison between studies.

Keywords

Alzheimer's disease - bioinformatics - Chinese herbs - Chinese herbal compound - biomarkers - therapeutic targets

CRediT Authorship Contribution Statement

Zhiyang Yu: Conceptualization, data curation, software, and writing original draft. Wenpan Wang: Visualization, and formal analysis. Qiong Qiao: Data curation, and writing-review and editing. Yiran Sun: Software and methodology. Zhishen Xie and Junying Song: Project administration, writing-review and editing. Zhenqiang Zhang and Huifen Ma: Funding acquisition, supervision, writing-review and editing.




Publication History

Received: 12 November 2023

Accepted: 29 December 2023

Article published online:
30 March 2024

© 2024. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution License, permitting unrestricted use, distribution, and reproduction so long as the original work is properly cited. (https://creativecommons.org/licenses/by/4.0/)

Georg Thieme Verlag KG
Rüdigerstraße 14, 70469 Stuttgart, Germany

 

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