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CC BY 4.0 · Pharmaceutical Fronts 2024; 06(01): e9-e19
DOI: 10.1055/s-0044-1780505
Review Article

Electrochemical Construction of C–S Bond: A Green Approach for Preparing Sulfur-Containing Scaffolds

Ruonan Zou
1   College of Ecology, Lishui University, Lishui, People's Republic of China
,
Jingbo Yu
2   Key Laboratory for Green Pharmaceutical Technologies and Related Equipment of Ministry of Education and Key Laboratory of Pharmaceutical Engineering of Zhejiang Province, Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals, Zhejiang University of Technology, Hangzhou, People's Republic of China
,
Ping Ying
1   College of Ecology, Lishui University, Lishui, People's Republic of China
› Author Affiliations Funding We are grateful to the Key R&D Plan Projects of Lishui (Grant No. 2023zdyf11), Zhejiang Provincial Key R&D Project (Grant Nos. 2020C03006 & 2019-ZJ-JS-03), and the Zhejiang Provincial College Student Science and Technology Innovation Activity Plan and New Talent Plan (Grant No. 2022R434A016) for financial support.
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Abstract

The organosulfur frameworks containing C–S bonds are important structural motifs in various biologically active molecules and functional materials. In this regard, transition-metal catalysis using chemical oxidants to prime reactions has emerged as the most common method, however, is prone to several side reactions such as dimerization and overoxidation. In recent years, organic electrosynthesis has become a hot topic due to its eco-friendly and mild process in which costly catalysts and toxic oxidants could be replaced by electrons. This perspective summarized the recently developed C–S bond electrosynthesis protocols, discussing and highlighting reaction features, substrate scope, as well as its application in pharmaceuticals, and the underlying reaction mechanisms. The study helps the development of electrochemical process-enabled C–S bond construction reactions in the future.

Keywords

electrochemical - sulfur-containing compounds - C–S bond


Publication History

Received: 29 July 2023

Accepted: 30 January 2024

Article published online:
11 March 2024

© 2024. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution License, permitting unrestricted use, distribution, and reproduction so long as the original work is properly cited. (https://creativecommons.org/licenses/by/4.0/)

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