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CC BY 4.0 · World J Nucl Med
DOI: 10.1055/s-0044-1779751
Case Report

FDG-PET in HIV-Positive Patient with Extranodal Diffuse Large B-Cell Lymphoma

Faizullah Mashriqi
1   Division of Neuroradiology, Department of Radiology, Northwell Health / Donald and Barbara Zucker School of Medicine, Lenox Hill Hospital, New York, New York, United States
,
Graham Keir
1   Division of Neuroradiology, Department of Radiology, Northwell Health / Donald and Barbara Zucker School of Medicine, Lenox Hill Hospital, New York, New York, United States
,
Joseph E. Glaser 
2   Division of Nuclear Medicine, Department of Radiology, Northwell Health / Donald and Barbara Zucker School of Medicine, Manhasset, New York, United States
,
Ana M. Franceschi 
1   Division of Neuroradiology, Department of Radiology, Northwell Health / Donald and Barbara Zucker School of Medicine, Lenox Hill Hospital, New York, New York, United States
,
Akarsh Vijayashankar
1   Division of Neuroradiology, Department of Radiology, Northwell Health / Donald and Barbara Zucker School of Medicine, Lenox Hill Hospital, New York, New York, United States
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Abstract

Extranodal diffuse large B-cell lymphoma (DLBCL) is a heterogeneous disease process and an aggressive form of non-Hodgkin's lymphoma. We present a case of multiorgan involvement of DLBCL in a patient with documented risk factors, including [18F] fluorodeoxyglucose positron emission tomography/magnetic resonance imaging findings highlighting striking perineural spread involving intracranial and extracranial segments of the bilateral trigeminal nerves.

Keywords

extranodal lymphoma - diffuse large B-cell lymphoma - perineural spread - PET/MRI - brain PET

Authors' Contributions

F.M. and G.K. were involved in writing (original draft) and review and editing. J.E.G. helped in conceptualization, data curation, resources, and writing (review and editing). A.M.F. contributed to conceptualization, data curation, resources, software, supervision, writing (original draft), and review and editing.




Publication History

Article published online:
25 April 2024

© 2024. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution License, permitting unrestricted use, distribution, and reproduction so long as the original work is properly cited. (https://creativecommons.org/licenses/by/4.0/)

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  • References

  • 1 Sehn LH, Salles G. Diffuse large B-cell lymphoma. N Engl J Med 2021; 384 (09) 842-858
    CrossrefPubMedGoogle Scholar
  • 2 Ollila TA, Olszewski AJ. Extranodal diffuse large B cell lymphoma: molecular features, prognosis, and risk of central nervous system recurrence. Curr Treat Options Oncol 2018; 19 (08) 38
    CrossrefPubMedGoogle Scholar
  • 3 Villa D, Connors JM, Sehn LH, Gascoyne RD, Savage KJ. Diffuse large B-cell lymphoma with involvement of the kidney: outcome and risk of central nervous system relapse. Haematologica 2011; 96 (07) 1002-1007
    CrossrefPubMedGoogle Scholar
  • 4 Lehners N, Krämer I, Schwarzbich MA, Ho AD, Witzens-Harig M. Analysis of clinical characteristics and outcome of patients with previously untreated diffuse large B-cell lymphoma and renal involvement in the rituximab era. Leuk Lymphoma 2016; 57 (11) 2619-2625
    CrossrefPubMedGoogle Scholar
  • 5 Ferreri AJM. Risk of CNS dissemination in extranodal lymphomas. Lancet Oncol 2014; 15 (04) e159-e169
    CrossrefPubMedGoogle Scholar
  • 6 Schmitz N, Zeynalova S, Nickelsen M. et al. CNS international prognostic index: a risk model for CNS relapse in patients with diffuse large B-cell lymphoma treated with R-CHOP. J Clin Oncol 2016; 34 (26) 3150-3156
    CrossrefPubMedGoogle Scholar
  • 7 Møller MB, Pedersen NT, Christensen BE. Diffuse large B-cell lymphoma: clinical implications of extranodal versus nodal presentation–a population-based study of 1575 cases. Br J Haematol 2004; 124 (02) 151-159
    CrossrefPubMedGoogle Scholar
  • 8 Boussios S, Zerdes I, Vassou A. et al. Extranodal diffuse large B-cell lymphomas: a retrospective case series and review of the literature. Hematol Rep 2018; 10 (01) 7070
    CrossrefPubMedGoogle Scholar
  • 9 Barta SK, Xue X, Wang D. et al. Treatment factors affecting outcomes in HIV-associated non-Hodgkin lymphomas: a pooled analysis of 1546 patients. Blood 2013; 122 (19) 3251-3262
    CrossrefPubMedGoogle Scholar
  • 10 Besson C, Lancar R, Prevot S. et al; ANRS-CO16 LYMPHOVIR Cohort. Outcomes for HIV-associated diffuse large B-cell lymphoma in the modern combined antiretroviral therapy era. AIDS 2017; 31 (18) 2493-2501
    CrossrefPubMedGoogle Scholar
  • 11 Cronin CG, Swords R, Truong MT. et al. Clinical utility of PET/CT in lymphoma. AJR Am J Roentgenol 2010; 194 (01) W91-W103
    CrossrefPubMedGoogle Scholar
  • 12 Sarikaya I. Biology of cancer and PET imaging: pictorial review. J Nucl Med Technol 2022; DOI: 10.2967/jnmt.121.263534.
    CrossrefPubMedGoogle Scholar
  • 13 Smith AB, Smirniotopoulos JG, Rushing EJ. From the archives of the AFIP: central nervous system infections associated with human immunodeficiency virus infection: radiologic-pathologic correlation. Radiographics 2008; 28 (07) 2033-2058 DOI: 10.1148/rg.287085135. Erratum in: Radiographics. 2009 Mar-Apr;29(2):638
    CrossrefPubMedGoogle Scholar
  • 14 Tanwar M, Branstetter Iv BF. Mimics of perineural tumor spread in the head and neck. Br J Radiol 2021; 94 (1128): 20210099
    CrossrefPubMedGoogle Scholar
  • 15 Ang JW, Khanna A, Walcott BP, Kahle KT, Eskandar EN. Central nervous system lymphoma presenting as trigeminal neuralgia: a diagnostic challenge. J Clin Neurosci 2015; 22 (07) 1188-1190
    CrossrefPubMedGoogle Scholar
  • 16 Yılmaz S, Sağer S, Sen F, Halac M. Bilateral trigeminal nerve recurrence of non-Hodgkin lymphoma revealed with FDG PET/CT. Indian J Nucl Med 2014; 29 (01) 50-52
    CrossrefPubMedGoogle Scholar