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CC BY 4.0 · Indian J Med Paediatr Oncol 2024; 45(02): 115-126
DOI: 10.1055/s-0044-1779621
Review Article

FLT3 and IDH1/2 Inhibitors for Acute Myeloid Leukemia: Focused Clinical Narrative Review of Forthcoming Drugs from an Indian Context

Suvir Singh 
1   Department of Clinical Hematology, Dayanand Medical College, Ludhiana, Punjab, India
,
Kunal Jain
2   Department of Medical Oncology, Dayanand Medical College, Ludhiana, Punjab, India
,
Jagdeep Singh
2   Department of Medical Oncology, Dayanand Medical College, Ludhiana, Punjab, India
,
Nitish Garg
2   Department of Medical Oncology, Dayanand Medical College, Ludhiana, Punjab, India
,
Akriti Arora
1   Department of Clinical Hematology, Dayanand Medical College, Ludhiana, Punjab, India
› Author Affiliations Funding None declared.
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Abstract

Therapeutic approaches for acute myeloid leukemia (AML) have witnessed minimal evolution in recent decades, primarily relying on advancements in supportive care and transplantation to drive improvements in overall survival rates. However, treatment with intensive chemotherapy may not be feasible for patients with advanced age or reduced fitness, and outcomes for patients with relapsed/refractory disease continue to be suboptimal. Several agents with a novel mechanism of action have been developed in the past decade and have shown efficacy in patients with both newly diagnosed and relapsed AML. Out of these, several FLT3 (FMS like tyrosine kinase 3) and IDH1/2 (isocitrate dehydrogenase 1/2) inhibitors have received regulatory approval in specific clinical settings and are available for clinical use. This is an actively expanding field with several ongoing clinical trials in advanced phases. We provide a focused narrative review of drugs from these two categories with available clinical data.

Keywords

myeloid - leukemia - FLT3 - midostaurin - gilteritinib - sorafenib

Patient Consent

None declared.




Publication History

Article published online:
09 February 2024

© 2024. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution License, permitting unrestricted use, distribution, and reproduction so long as the original work is properly cited. (https://creativecommons.org/licenses/by/4.0/)

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