Download PDF
CC BY 4.0 · Glob Med Genet 2024; 11(01): 034-035
DOI: 10.1055/s-0044-1779041
Short Communication

On the Pentapeptide as the Measurement Unit in Immunology

Darja Kanduc 
1   Department of Biosciences, Biotechnologies, and Biopharmaceutics, University of Bari, Bari, Italy
› Author Affiliations
› Further Information
Also available at
   Permissions and Reprints

Abstract

This communication concerns a crucial query in immunology, that is, the dimension of an epitope. The issue has essential implications in vaccine formulations.

Keywords

epitope dimensions - pentapeptides - vaccines


Publication History

Article published online:
18 January 2024

© 2024. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution License, permitting unrestricted use, distribution, and reproduction so long as the original work is properly cited. (https://creativecommons.org/licenses/by/4.0/)

Georg Thieme Verlag KG
Rüdigerstraße 14, 70469 Stuttgart, Germany

 

  • References

  • 1 Landsteiner K, van der Scheer J. On the serological specificity of peptides. III. J Exp Med 1939; 69 (05) 705-719
    CrossrefPubMedGoogle Scholar
  • 2 Landsteiner K. The Specificity of Serological Reactions. New York: Dover Publications, Inc.; 1962: 58
    Google Scholar
  • 3 Heymer B, Bernstein D, Schleifer KH, Krause RM. A radioactive hapten-binding assay for measuring antibodies to the pentapeptide determinant of peptidoglycan. J Immunol 1975; 114 (04) 1191-1196
    CrossrefPubMedGoogle Scholar
  • 4 Van Oss CJ. Nature of specific ligand-receptor bonds, in particular the antigen-antibody bond. In: van Oss CJ, van Regenmortel MHV. eds. Immunochemistry. New York: Marcel Dekker; 1994: 581-614
    Google Scholar
  • 5 van Oss CJ. Antigen-antibody reactions. In: van Regenmortel MHV. ed. Structure of Antigens. Boca Raton: CRC Press; 1992: 99-126
    Google Scholar
  • 6 Kanduc D. Immunogenicity in peptide-immunotherapy: from self/nonself to similar/dissimilar sequences. Adv Exp Med Biol 2008; 640: 198-207
    CrossrefPubMedGoogle Scholar
  • 7 Kanduc D. Homology, similarity, and identity in peptide epitope immunodefinition. J Pept Sci 2012; 18 (08) 487-494
    CrossrefPubMedGoogle Scholar
  • 8 Kanduc D. Hydrophobicity and the physico-chemical basis of immunotolerance. Pathobiology 2020; 87 (04) 268-276
    CrossrefPubMedGoogle Scholar
  • 9 Kanduc D. The role of proteomics in defining autoimmunity. Expert Rev Proteomics 2021; 18 (03) 177-184
    CrossrefPubMedGoogle Scholar