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DOI: 10.1055/s-0044-101624
An Update on the Biological Activities of Euterpe edulis (Juçara)
Publication History
received 29 June 2017
revised 11 January 2018
accepted 21 January 2018
Publication Date:
21 February 2018 (online)
Abstract
The palm tree Euterpe edulis, known as juçara, produces spherical and purple fruits, similar to those of the Euterpe oleracea and Euterpe precatoria palm trees, from which the common name açaí originates. Juçara fruit has been gaining prominence in the scientific world for its interesting nutritional composition, which is rich in antioxidants, and for its sustainable production model. Recently, relevant biological activities have been associated with the juçara fruit, and its use in alimentation has become an important nutritional, environmental, and economic alternative. The aim of this review is to compile recent scientific data about the phytochemical characterization and biological activities of E. edulis. A review of the literature was conducted in two electronic databases, Medline and Science Direct. The eligibility criteria were as follows: phytochemicals characterize of the E. edulis fruits and evaluate biological effects in vitro or in vivo with pulp, extract, juice, or product of juçara fruits. Investigations were excluded if they used other parts of the plant (seeds), did not assess biological activities, or have tested methodologies for compound extraction. From the identified reports, 25 articles were eligible for this study. The promotion of health benefits related to juçara fruits seems to have improved antioxidant activity in vivo, benefits to lipid and glycemic profiles, and modulation of inflammatory status in experimental studies in animals.
Supporting Information
- Supporting Information
A flow chart of the selection of studies is available as Supporting Information (Fig. 1S).
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References
- 1 Crowe FL, Roddam AW, Key TJ, Appleby PN, Overvad K, Jakobsen MU, Tjønneland A, Hansen L, Boeing H, Weikert C, Linseisen J, Kaaks R, Trichopoulou A, Misirli G, Lagiou P, Sacerdote C, Pala V, Palli D, Tumino R, Panico S, Bueno-de-Mesquita HB, Boer J, Van Gils CH, Beulens JW, Barrocarte A, Rodríguez L, Larrañaga N, Sánchez MJ, Tormo MJ, Buckland G, Lund E, Hedblad B, Malander O, Jasson JH, Wennberg P, Wareham NJ, Slimani N, Romieu I, Jenab M, Danesh J, Gallo V, Norat T, Riboli E. Fruit and vegetable intake and mortality from ischaemic heart disease: results from the European Prospective Investigation into Cancer and Nutrition (EPIC)-Heart study. Eur Heart J 2011; 32: 1235-1243
- 2 Spencer JPE, Crozier A. eds. Flavonoids and related Compounds: Bioavailability and Function of Flavonoids: oxidative Stress and Disease. 1st ed.. ed. Boca Raton, FL: CRC Press; 2012: 45-78
- 3 Del Rio D, Rodriguez-Mateos A, Spencer JP, Tognolini M, Borges G, Crozier A. Dietary (poly)phenolics in human health: structures, bioavailability, and evidence of protective effects against chronic diseases. Antioxid Redox Signal 2013; 18: 1818-1892
- 4 Costa AGV, Garcia-Diaz DF, Jimenez P, Silva PI. Bioactive compounds and health benefits of exotic tropical red-blackberries. J Funct Foods 2013; 5: 539-549
- 5 Harasym J, Oledzki R. Effect of fruit and vegetable antioxidants on total antioxidant capacity of blood plasma. Nutrition 2014; 30: 511-517
- 6 Yamaguchi KKL, Pereira LFR, Lamarão CV, Lima ES, da Veiga-Junior VF. Amazon açai: chemistry and biological activities: a review. Food Chem 2015; 179: 137-151
- 7 Chaimsohn FP, Chiquetto NC. Construção do marco legal para a produção de açaí de juçara: contribuições da “oficina interestadual sobre legislação, comercialização e marketing para exploração de frutos da palmeira juçara”. Rev Conexão 2013; 9: 244-253
- 8 Borges GSC, Vieira FGK, Copetti C, Gonzaga LV, Zambiazi RC, Mancini Filho J, Fett R. Chemical characterization, bioactive compounds, and antioxidant capacity of jussara (Euterpe edulis) fruit from the Atlantic Forest in southern Brazil. Food Res Int 2011; 44: 2128-2133
- 9 Borges GSC, Gonzaga LV, Jardini FA, Mancini Filho J, Heller M, Micke G, Costa ACO, Fett R. Protective effect of Euterpe edulis M. on Vero cell culture and antioxidant evaluation based on phenolic composition using HPLC-ESI-MS/MS. Food Res Int 2013; 51: 363-369
- 10 Bicudo MO, Ribani RH, Beta T. Anthocyanins, phenolic acids and antioxidant properties of juçara fruits (Euterpe edulis M.) along the on-tree ripening process. Plant Food Hum Nutr 2014; 69: 142-147
- 11 Inada KOP, Oliveira AA, Revorêdo TB, Martins ABN, Lacerda ECQ, Freire AS, Braz BF, Santelli RE, Torres AG, Perrone D, Monteiro MC. Screening of the chemical composition and occurring antioxidants in jabuticaba (Myrciaria jaboticaba) and jussara (Euterpe edulis) fruits and their fractions. J Funct Foods 2015; 17: 422-433
- 12 Schulz M, Borges GSC, Gonzaga LV, Costa ACO, Fett R. Juçara fruit (Euterpe edulis Mart.): sustainable exploitation of a source of bioactive compounds. Food Res Int 2016; 89: 14-26
- 13 da Silva NA, Rodrigues E, Mercadante AZ, De Rosso VV. Phenolic compounds and carotenoids from four fruits native from the Brazilian Atlantic forest. J Agric Food Chem 2014; 62: 5072-5084
- 14 de Castro CA, Natali AJ, Cardoso LM, Ferreira-Machado AB, Novello AA, da Silva KA, Tafuri NF, da Mata SL, Pedrosa ML, Peluzio MC. Aerobic exercise and not a diet supplemented with jussara açaí (Euterpe edulis Martius) alters hepatic oxidative and inflammatory biomarkers in ApoE-deficient mice. Br J Nutr 2014; 112: 285-294
- 15 Cardoso AL, Di Pietro PF, Vieira FGK, Boaventura BCB, De Liz S, Borges GSC, Fett R, Andrade DF, da Silva EL. Acute consumption of juçara juice (Euterpe edulis) and antioxidant activity in healthy individuals. J Funct Foods 2015; 17: 152-162
- 16 Cardoso LM, Novaes RD, Castro CA, Novello AA, Goncalves RV, Ricci-Silva ME, Ramos HJO, Peluzio MCG, Leite JPV. Chemical composition, characterization of anthocyanins and antioxidant potential of Euterpe edulis fruits: applicability on genetic dyslipidemia and hepatic steatosis in mice. Nutr Hosp 2015; 32: 702-709
- 17 Novello AA, Conceição LL, Dias MMS, Cardoso LM, de Castro CA, Ricci-Silva ME, Leite JPV, Peluzio MCG. Chemical characterization, antioxidant and antiatherogenic activity of anthocyanin-rich extract from Euterpe edulis Mart. in mice. J Food Nutr Res 2015; 54: 101-112
- 18 Oyama LM, Silva FP, Carnier J, de Miranda DA, Santamarina AB, Ribeiro EB, Oller do Nascimento CM, De Rosso VV. Juçara pulp supplementation improves glucose tolerance in mice. Diabetol Metab Syndr 2016; 8: 1-8
- 19 Schulz M, Borges GSC, Gonzaga LV, Seraglio SKT, Olivo IS, Azevedo MS, Nehring P, Gois JS, Almeida TS, Vitali L, Spudeit DA, Micke GA, Borges DLG, Fett R. Chemical composition, bioactive compounds and antioxidant capacity of juçara fruit (Euterpe edulis Martius) during ripening. Food Res Int 2015; 77: 125-131
- 20 da Silva PPM, do Carmo LF, Silva GM, Silveira-Diniz MF, Casemiro RC, Spoto MHF. Physical, chemical, and lipid composition of juçara (Euterpe edulis Mart.) pulp. Braz J Food Nutr 2013; 24: 7-13
- 21 Institute of Medicine (US). Panel on Micronutrients. Dietary reference intakes for vitamin A, vitamin K, arsenic, boron, chromium, copper, iodine, iron, manganese, molybdenum, nickel, silicon, vanadium, and zinc. Washington DC: National Academy Press; 2001. Available at https://www.ncbi.nlm.nih.gov/books/NBK222310/ Accessed September 22, 2017
- 22 Schulz M, Biluca FC, Gonzaga LV, Borges GD, Vitali L, Micke GA, de Gois JS, de Almeida TS, Borges DL, Miller PR, Costa AC, Fett R. Bioaccessibility of bioactive compounds and antioxidant potential of Juçara fruits (Euterpe edulis Martius) subjected to in vitro gastrointestinal digestion. Food Chem 2017; 228: 447-454
- 23 Rufino MSM, Alves RE, Brito ES, Pérez-Jiménez J, Saura-Calixto F, Mancini Filho J. Bioactive compounds and antioxidant capacities of 18 non-traditional tropical fruits from Brazil. Food Chem 2010; 121: 996-1002
- 24 Britton G, Khachik F. Carotenoids Nutrition and Health. In: Britton G, Liaaen-Jensen S, Pfander H. eds. Carotenoids in Food. Boston, MA: Birkhauser Basel; 2009: 45-66
- 25 Schauss AG, Wu X, Prior RL, Ou B, Patel D, Huang D, Kababick JP. Phytochemical and nutrient composition of the freezedried Amazonian palm berry, Euterpe oleraceae Mart. (acai). J Agric Food Chem 2006; 54: 8598-8603
- 26 Guergoletto KB, Costabile A, Flores G, Garcia S, Gibson GR. In vitro fermentation of Juçara pulp (Euterpe edulis) by human colonic microbiota. Food Chem 2016; 196: 251-258
- 27 De Brito ES, Araújo MCP, Alves RE, Carkeet C, Clevidence B, Novotny JA. Anthocyanins present in selected tropical fruits: acerola, jambolão, jussara, and guajiru. J Agric Food Chem 2007; 55: 9389-9394
- 28 Peron DV, Fraga S, Antelo F. Thermal degradation kinetics of anthocyanins extracted from juçara (Euterpe edulis Martius) and “Italia” grapes (Vitis vinifera L.), and the effect of heating on the antioxidant capacity. Food Chem 2017; 232: 836-840
- 29 Vieira GS, Marques ASF, Machado MTC, Silva VM, Hubinger MD. Determination of anthocyanins and non-anthocyanin polyphenols by ultra performance liquid chromatography/electrospray ionization mass spectrometry (UPLC/ESI-MS) in jussara (Euterpe edulis) extracts. J Food Sci Technol 2017; 54: 2135-2144
- 30 Vieira GS, Cavalcanti RN, Meireles MAA, Hubinger MD. Chemical and economic evaluation of natural antioxidant extracts obtained by ultrasound-assisted and agitated bed extraction from jussara pulp (Euterpe edulis). J Food Eng 2013; 119: 196-204
- 31 Kang J, Thakali KM, Xie C, Kondo M, Tong Y, Ou B, Jensen G, Medina MB, Schauss AG, Wu X. Bioactivities of açaí (Euterpe precatoria Mart.) fruit pulp, superior antioxidant and anti-inflammatory properties to Euterpe oleracea Mart. Food Chem 2012; 133: 671-677
- 32 Lowe F. Biomarkers of oxidative Stress. In: Laher I. ed. Systems Biology of free Radicals and Antioxidants. Berlin, Germany: Springer; 2014: 65-87
- 33 Halliwell B. Free radicals and antioxidants – quo vadis?. Trends Pharmacol Sci 2011; 32: 125-130
- 34 Freitas RB, Novaes RD, Gonçalves RV, Mendonça BG, Santos EC, Ribeiro AQ, Lima LM, Fietto LG, Peluzio MCG, Leite JPV. Euterpe edulis: extract but not oil enhances antioxidant defenses and protects against nonalcoholic fatty liver disease induced by a high-fat diet in rats. Oxid Med Cell Longev 2016; 2016: 8173876
- 35 Del Bó C, Martini D, Porrini M, Klimis-Zacas D, Riso P. Berries and oxidative stress markers: an overview of human intervention studies. Food Funct 2015; 6: 2890-2917
- 36 Motohashi N, Sakagami H. Anthocyanins as functional Food Colors. In: Hoop H, Swart P. eds. Bioactive Heterocycles VII. Berlin, Germany: Springer; 2009
- 37 Kostogrys RB, Franczyk-Żarów M, Maślak E, Gajda M, Mateuszuk L, Jackson CL, Chłopicki S. Low carbohydrate, high protein diet promotes atherosclerosis in apolipoprotein E/low-density lipoprotein receptor double knockout mice (apoE/LDLR−/−). Atherosclerosis 2012; 223: 327-331
- 38 Gonçalves RV, Novaes RD, Leite JP, Vilela EF, Cupertino MC, Nunes LG, Matta SL. Hepatoprotective effect of Bathysa cuspidata in a murine model of severe toxic liver injury. Int J Exp Pathol 2012; 93: 370-376
- 39 Novaes RD, Gonçalves RV, Marques DC, Cupertino MC, Peluzio MC, Leite JP, Maldonado IR. Effect of bark extract of Bathysa cuspidata on hepatic oxidative damage and blood glucose kinetics in rats exposed to paraquat. Toxicol Pathol 2012; 40: 62-70
- 40 Freitas RB, Rômulo DN, Bianca GM, Eliziária CS, Murilo SA, Luciano GF, Luciana ML, Maria do Carmo P, Reggiani VVG, João Paulo L. Euterpe edulis extracts positively modulates the redox status and expression of inflammatory mediators. Food Agric Immunol 2017; DOI: 10.1080/09540105.2017.1360255.
- 41 Freitas RB, Melato FA, Oliveira JM, Bastos DS, Cardoso RM, Leite JPV, Lima LM. Euterpe edulis effects on cardiac and renal tissues of Wistar rats fed with cafeteria diet. Nutr Hosp 2017; 34: 186-192
- 42 Bhooshan KP, Pandey KB, Rizv SI. Plant polyphenols as dietary antioxidants in human health and disease. Oxid Med Cell Longev 2009; 2: 270-278
- 43 Lei XG, Zhu JH, Cheng WH, Bao Y, Ho YS, Reddi AR, Holmgren A, Arnér ES. Paradoxical roles of antioxidant enzymes: basic mechanisms and health implications. Physiol Rev 2016; 96: 307-364
- 44 Tsuda T. Dietary anthocyanin-rich plants: biochemical basis and recent progress in health benefits studies. Mol Nutr Food Res 2012; 56: 159-170
- 45 Shih PH, Yeh CT, Yen GC. Effects of anthocyanidin on the inhibition of proliferation and induction of apoptosis in human gastric adenocarcinoma cells. Food Chem Toxicol 2005; 43: 1557-1566
- 46 Toufektsian MC, Lorgeril M, Nagy N, Salen P, Donati MB, Giordano L, Mock HP, Peterek S, Matros A, Petroni K, Pilu R, Rotilio D, Tonelli C, de Leiris J, Boucher F, Martin C. Chronic dietary intake of plant-derived anthocyanins protects the rat heart against ischemia-reperfusion injury. J Nutr 2008; 138: 747-752
- 47 Reis JF, Monteiro VVS, Gomes RS, do Carmo MM, da Costa GV, Ribera PC, Monteiro MC. Action mechanism and cardiovascular effect of anthocyanins: a systematic review of animal and human studies. J Transl Med 2016; 14: 315
- 48 Rodriguez-Mateos A, Heiss C, Borges G, Crozier A. Berry (poly)phenols and cardiovascular health. J Agric Food Chem 2014; 62: 3842-3851
- 49 Gordon T, Castelli WP, Hjortland MC, Kannel WB, Dawber TR. High density lipoprotein as a protective factor against coronary heart disease. The Framingham Study. Am J Med 1977; 62: 707-714
- 50 Grammer TB, Kleber ME, Marz W, Silbernagel G, Siekmeier R, Wieland H, Pilz S, Tomaschitz A, Koenig W, Scharnagl H. Low-density lipoprotein particle diameter and mortality: the Ludwigshafen risk and cardiovascular health study. Eur Heart J 2015; 36: 31-38
- 51 Nile SH, Park SW. Edible berries: bioactive components and their effect on human health. Nutrition 2014; 30: 134-144
- 52 Kruger MJ, Davies N, Myburgh KH, Lecour S. Proanthocyanidins, anthocyanins and cardiovascular diseases. Food Res Int 2014; 59: 41-52
- 53 Harris WS, Bulchandani D. Why do omega-3 fatty acids lower serum triglycerides?. Curr Opin Lipidol 2006; 17: 387-393
- 54 Morais CA, Oyama LM, Oliveira JL, Garcia MC, Rosso VV, Amigo LSM, Nascimento CM, Pisani LP. Jussara (Euterpe edulis Mart.) supplementation during pregnancy and lactation modulates the gene and protein expression of inflammation biomarkers induced by trans-fatty acids in the colon of offspring. Mediators Inflamm 2014; 2014: 987927
- 55 Argentato PP, Morais CA, Santamarina AB, Cesar HC, Estadella D, Rosso VV, Pisani LP. Jussara (Euterpe edulis Mart.) supplementation during pregnancy and lactation modulates UCP-1 and inflammation biomarkers induced by trans-fatty acids in the brown adipose tissue of offspring. Clin Nutr Exp 2017; 12: 50-65
- 56 Takikawa M, Inoue S, Horio F, Tsuda T. Dietary anthocyanin-rich bilberry extract ameliorates hyperglycemia and insulin sensitivity via activation of AMP-activated protein kinase in diabetic mice. J Nutr 2010; 140: 527-533
- 57 Joseph SV, Edirisinghe I, Burton-Freeman BM. Berries: anti-inflammatory effects in humans. J Agric Food Chem 2014; 62: 3886-3903
- 58 Tangney CC, Rasmussen HE. Polyphenols, inflammation, and cardiovascular disease. Curr Atheroscler 2013; 15: 324
- 59 Wallace TC. Anthocyanins in cardiovascular disease. Adv Nutr 2011; 2: 1-7
- 60 Zhang H, Liu R, Tsao R. Anthocyanin-rich phenolic extracts of purple root vegetables inhibit pro-inflammatory cytokines induced by H2O2 and enhance antioxidant enzyme activities in Caco-2 cells. J Funct Foods 2016; 22: 363-375
- 61 Jiang M, Klein M, Zanger UM, Mohammad MK, Cave MC, Gaikwad NW, Dias NJ, Selcer KW, Guo Y, He J, Zhang X, Shen Q, Qin W, Li J, Li S, Xie W. Inflammatory regulation of steroid sulfatase: A novel mechanism to control estrogen homeostasis and inflammation in chronic liver disease. J Hepatol 2016; 64: 44-52
- 62 Morais CA, Oyama LM, Conrado RM, Rosso VV, Nascimento CO, Pisani LP. Polyphenols-rich fruit in maternal diet modulates inflammatory markers and the gut microbiota and improves colonic expression of ZO-1 in offspring. Food Res Int 2015; 77: 186-193
- 63 Jakobsdottir G, Blanco N, Xu J, Ahrné S, Molin G, Sterner O, Nyman M. Formation of short-chain fatty acids, excretion of anthocyanins, and microbial diversity in rats fed blackcurrants, blackberries, and raspberries. J Nutr Metab 2013; 1-12
- 64 Hamada K, Shitara Y, Sekine S, Horie T. Zonula occludens-1 alterations and enhanced intestinal permeability in methotrexate-treated rats. Cancer Chemother Pharmacol 2010; 66: 1031-1038
- 65 Hamada K, Kakigawa N, Sekine S, Shitara Y, Horie T. Disruption of ZO-1/claudin-4 interaction in relation to inflammatory responses in methotrexateinduced intestinal mucositis. Cancer Chemother Pharmacol 2013; 72: 757-765
- 66 Felzenszwalb I, da Costa Marques MR, Mazzei JL, Aiub CAF. Toxicological evaluation of Euterpe edulis: a potential superfruit to be considered. Food Chem Toxicol 2013; 58: 536-544
- 67 Geraldi MV, Tulini FL, Souza VM, De Martinis ECP. Development of yoghurt with juçara pulp (Euterpe edulis M.) and the probiotic Lactobacillus acidophilus La5. Probiotics Antimicrob Proteins 2017; DOI: 10.1007/s12602-017-9280-z.