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CC BY 4.0 · Indian J Med Paediatr Oncol
DOI: 10.1055/s-0043-1778110
Case Report with Review of Literature

Secondary Histiocytic Sarcoma in a Pre-B-Acute Lymphoblastic Leukemia

Sharanya Ramakrishnan 
1   Department of Clinical Haematology and Cellular Therapies, Tata Medical Center, Kolkata, West Bengal, India
,
Vivek Radhakrishnan 
1   Department of Clinical Haematology and Cellular Therapies, Tata Medical Center, Kolkata, West Bengal, India
,
Aaishwarya Dhabe
2   Department of Cytogenetics, Tata Medical Center, Kolkata, West Bengal, India
,
Mayur Parihar
3   Department of Cytogenetics & Laboratory Haematology, Tata Medical Center, Kolkata, West Bengal, India
,
Lateef Zameer
4   Department of Pathology, Tata Medical Center, Kolkata, West Bengal, India
,
Neeraj Arora 
5   Unipath Speciality Laboratory, Ahmedabad, Gujarat, India
,
Reena Nair 
6   Head, Department of Clinical Hematology and Cellular therapies, Tata Medical Center, Kolkata, West Bengal, India
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Abstract

Histiocytic sarcoma (HS) is a rare malignancy with grave prognosis. Adult acute lymphoblastic leukemia (ALL) patients developing HS as a secondary malignancy reported in the literature is even rarer. Through our case report, we aim to describe an adult pre-B-ALL patient who subsequently developed extensive HS while on maintenance therapy. We present the course of the disease, the management, and the resultant outcome. Active reporting of the course and management of secondary HS in adult ALL patients need to be emphasized to gain better insight into the presentation and the course of the disease, incidence as well as molecular pathology, especially given the relative silence of the literature in this regard.

Keywords

secondary HS - adult pre-B-ALL - secondary malignancies

Patient Consent

The name of the department(s) and institution(s) to which the work should be attributed:

Department of Clinical Hematology and Cellular Therapies, Department of Cytogenetics, Department of Pathology and Department of Laboratory Hematology, Tata Medical Center, Kolkata, West Bengal, India

1. The manuscript has been read and approved by all the authors and the requirements for authorship have been met by each author. Each author believes that the manuscript represents honest work to the best of their knowledge.

2. There are no source of funding and conflict of interest to be declared.


Statement of Ethics

Ethical approval to report this case was obtained from Institutional Review Board (EC/WV/TMC/19/22).




Publication History

Article published online:
23 May 2024

© 2024. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution License, permitting unrestricted use, distribution, and reproduction so long as the original work is properly cited. (https://creativecommons.org/licenses/by/4.0/)

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