CC BY-NC-ND 4.0 · Sleep Sci
DOI: 10.1055/s-0043-1777784
Case Report

Looking beyond in Sleep Medicine Practice: Effect of OSA Management in Floppy Eyelid Syndrome – A Case Report

1   School of Medicine, Tehran University of Medical Sciences, Tehran, Tehran, Iran
2   Occupational Sleep Research Center, Baharloo Hospital, Tehran University of Medical Sciences, Tehran, Iran
,
Arman Soleimani
1   School of Medicine, Tehran University of Medical Sciences, Tehran, Tehran, Iran
2   Occupational Sleep Research Center, Baharloo Hospital, Tehran University of Medical Sciences, Tehran, Iran
,
2   Occupational Sleep Research Center, Baharloo Hospital, Tehran University of Medical Sciences, Tehran, Iran
3   Sleep-Disordered Breathing Research Center, Tehran University of Medical Sciences, Tehran, Tehran, Iran
,
Hamed Amirifard
4   Department of Neurology, The Iranian Center of Neurological Research, Department of Neurology, Imam Khomeini Hospital, Tehran University of Medical Sciences, Tehran, Iran
› Author Affiliations
Funding The authors declare that the present research received no specific grants from funding agencies in the public, commercial, or not-for-profit sectors.

Abstract

Obstructive Sleep Apnea Syndrome (OSA) is a common sleep disorder characterized by recurrent episodes of partial or complete upper airway obstruction during sleep. Floppy Eye Syndrome (FES) is a condition in which the upper eyelids easily evert with upward traction due to underlying tarsal plate laxity and is associated with chronic, reactive papillary conjunctivitis; this causes the eye to be vulnerable to discomfort and visual symptoms. A 49-year-old man with an 8-year history of snoring, sleep fragmentation, and daytime sleepiness was admitted as an outpatient in our sleep clinic. The patient had complied ocular symptoms such as burning eyes, redness, and irritative ocular symptoms in the past five years, arising upon waking up. The symptoms did not regress with the use of artificial tears and proper ointment. The patient was diagnosed with OSA and began using continuous positive airway pressure (CPAP). CPAP therapy significantly corrected the symptoms of FES associated with OSA . This would help to sensibilize ocular findings in patients with OSA and identify hidden sleeping diseases needing a more appropriate investigation and possible treatment. We must look beyond our approach to sleep clinic patients and avoid being kept to the common symptoms patients represent.

Ethical Considerations

Informed consent was obtained from the patient for the inclusion in the study.


Authors' Contributions

HBA: literature review, data collection, and writing and editing of the manuscript draft; AS: literature review, data collection, and writing of the manuscript draft; HA: patient management and follow-up, and review and editing of the manuscript. AN patient visit, management, and follow-up, and writing, review, and editing of the manuscript draft.




Publication History

Received: 14 March 2023

Accepted: 25 August 2023

Article published online:
20 February 2024

© 2024. Brazilian Sleep Association. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/)

Thieme Revinter Publicações Ltda.
Rua do Matoso 170, Rio de Janeiro, RJ, CEP 20270-135, Brazil

 
  • References

  • 1 Sleep-related breathing disorders in adults: recommendations for syndrome definition and measurement techniques in clinical research. The Report of an American Academy of Sleep Medicine Task Force. Sleep 1999; 22 (05) 667-689
  • 2 Golbidi S, Badran M, Ayas N, Laher I. Cardiovascular consequences of sleep apnea. Lung 2012; 190 (02) 113-132
  • 3 Kato M, Roberts-Thomson P, Phillips BG. et al. Impairment of endothelium-dependent vasodilation of resistance vessels in patients with obstructive sleep apnea. Circulation 2000; 102 (21) 2607-2610
  • 4 Urbano F, Roux F, Schindler J, Mohsenin V. Impaired cerebral autoregulation in obstructive sleep apnea. J Appl Physiol 2008; 105 (06) 1852-1857
  • 5 Nasr N, Traon AP, Czosnyka M, Tiberge M, Schmidt E, Larrue V. Cerebral autoregulation in patients with obstructive sleep apnea syndrome during wakefulness. Eur J Neurol 2009; 16 (03) 386-391
  • 6 Arzt M, Young T, Finn L, Skatrud JB, Bradley TD. Association of sleep-disordered breathing and the occurrence of stroke. Am J Respir Crit Care Med 2005; 172 (11) 1447-1451
  • 7 Jiménez Caballero PE, Coloma Navarro R, Ayo Martín O, Segura Martín T. Cerebral hemodynamic changes in obstructive sleep apnea syndrome after continuous positive airway pressure treatment. Sleep Breath 2013; 17 (03) 1103-1108
  • 8 Nieto FJ, Young TB, Lind BK. et al. Association of sleep-disordered breathing, sleep apnea, and hypertension in a large community-based study. Sleep Heart Health Study. JAMA 2000; 283 (14) 1829-1836
  • 9 Peppard PE, Young T, Palta M, Skatrud J. Prospective study of the association between sleep-disordered breathing and hypertension. N Engl J Med 2000; 342 (19) 1378-1384
  • 10 Shahar E, Whitney CW, Redline S. et al. Sleep-disordered breathing and cardiovascular disease: cross-sectional results of the Sleep Heart Health Study. Am J Respir Crit Care Med 2001; 163 (01) 19-25
  • 11 McNab AA. The eye and sleep apnea. Sleep Med Rev 2007; 11 (04) 269-276
  • 12 Kadyan A, Asghar J, Dowson L, Sandramouli S. Ocular findings in sleep apnoea patients using continuous positive airway pressure. Eye (Lond) 2010; 24 (05) 843-850
  • 13 Chambe J, Laib S, Hubbard J. et al. Floppy eyelid syndrome is associated with obstructive sleep apnoea: a prospective study on 127 patients. J Sleep Res 2012; 21 (03) 308-315
  • 14 Culbertson WW, Ostler HB. The floppy eyelid syndrome. Am J Ophthalmol 1981; 92 (04) 568-575
  • 15 Miyamoto C, Espírito Santo LC, Roisman L, Moreno PdeA, Cariello AJ, Osaki MH. Floppy eyelid syndrome: review. Arq Bras Oftalmol 2011; 74 (01) 64-66
  • 16 Salinas R, Puig M, Fry CL, Johnson DA, Kheirkhah A. Floppy eyelid syndrome: A comprehensive review. Ocul Surf 2020; 18 (01) 31-39
  • 17 Wang P, Yu DJ, Feng G. et al. Is Floppy Eyelid Syndrome More Prevalent in Obstructive Sleep Apnea Syndrome Patients?. J Ophthalmol 2016; 2016: 6980281
  • 18 Acar M, Firat H, Yuceege M, Ardic S. Long-term effects of PAP on ocular surface in obstructive sleep apnea syndrome. Can J Ophthalmol 2014; 49 (02) 217-221
  • 19 Chris McMillan KTK, Nathan W. Blessing. Floppy Eyelid Syndrome—Associations, Etiology, and Clinical Features. EyeNet Magazine 2021
  • 20 Muniesa MJ, Huerva V, Sánchez-de-la-Torre M, Martínez M, Jurjo C, Barbé F. The relationship between floppy eyelid syndrome and obstructive sleep apnoea. Br J Ophthalmol 2013; 97 (11) 1387-1390
  • 21 Porta R, Comini L, Barbano L, Bianchi L, Vitacca M. A case of obstructive sleep apnea syndrome associated with floppy eyelid syndrome: positive effect of CPAP therapy. Monaldi Arch Chest Dis 2017; 87 (01) 766
  • 22 Vieira MJ, Silva MJ, Lopes N, Moreira C, Carvalheira F, Sousa JP. Prospective Evaluation of Floppy Eyelid Syndrome at Baseline and after CPAP Therapy. Curr Eye Res 2021; 46 (01) 31-34