PDF herunterladen
CC BY-NC-ND 4.0 · Ibnosina Journal of Medicine and Biomedical Sciences 2024; 16(01): 017-020
DOI: 10.1055/s-0043-1777427
Original Article

Causes of Original Kidney Disease among Libyan Kidney Transplant Recipients

Jamila S. Elamouri 
1   Department of Internal Medicine, Tripoli Central Hospital, Tripoli, Libya
,
Ahmed A. Algeblawi 
1   Department of Internal Medicine, Tripoli Central Hospital, Tripoli, Libya
› Institutsangaben Funding and Sponsorship None.
› Weitere Informationen
   Lizenzen und Reprints

Abstract

Introduction End-stage renal disease (ESRD) has become a significant problem in the North African region. There are few references about the primary causes of ESRD in kidney transplant (KT) recipients. The aim of this study was to determine the causes of the original kidney disease in KT recipients in Tripoli Central Hospital, Tripoli, Libya.

Methods This is a hospital-based, retrospective descriptive study. It includes all KT recipients who were followed up in the outpatient clinic, at the Libyan National General Authority for Organ, Tissue, and Cell Transplantation and nephrology clinic in Tripoli Central Hospital during 2021, Tripoli, Libya.

Results Data on 360 KT recipients were retrieved. Sixty-eight percent of the of the patients were males: 31.1% of all enrolled individuals were between 31 and 40 years. Patient mean age was 36.66 ± 11.86 years. The most common validated cause for ESRD was unknown (55.3%), followed by chronic glomerulonephritis (CGN; 15%), diabetes mellitus and systemic hypertension each equally (10.3%), congenital abnormalities (3.6%), polycystic kidney disease (3.3%), and nephrolithiasis (1.9%).

Conclusion Original cause of kidney disease in most recipients was undetermined, possibly due to limited diagnostic tools or delayed presentation. However, CGN is a main known cause.

Keywords

kidney transplant - ESRD - chronic glomerulonephritis - etiology - Tripoli

Compliance with Ethical Principles

Although the study does not put any human subjects at any risk, approval was granted by the scientific committee of the transplant center. All data were collected anonymously.




Publikationsverlauf

Artikel online veröffentlicht:
13. Dezember 2023

© 2023. The Libyan Biotechnology Research Center. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/)

Thieme Medical and Scientific Publishers Pvt. Ltd.
A-12, 2nd Floor, Sector 2, Noida-201301 UP, India

 

  • References

  • 1 World Kidney Day. Chronic Kidney Disease. [Internet]. 12,12,18. 2015. Available at: http://www.worldkidneyday.org/faqs/chronic-kidney-disease [Accessed on May 22, 2023]
  • 2 Varol E, Karaca Sivrikaya S. Quality of life in chronic renal failure and nursing. Düzce Üniversitesi. Düzce Üniversitesi Sağlık Bilimleri Enstitüsü Dergisi 2018; 8: 89-96
    Google Scholar
  • 3 Grassmann A, Gioberge S, Moeller S, Brown G. ESRD patients in 2004: global overview of patient numbers, treatment modalities and associated trends. Nephrol Dial Transplant 2005; 20 (12) 2587-2593
    CrossrefPubMedGoogle Scholar
  • 4 Reikes ST. Trends in end-stage renal disease. Epidemiology, morbidity, and mortality. Postgrad Med 2000; 108 (01) 124-126 , 129–131, 135–136 passim
    CrossrefPubMedGoogle Scholar
  • 5 Saran R, Li Y, Robinson B. et al. US Renal Data System 2015 Annual Data Report: epidemiology of kidney disease in the United States. Am J Kidney Dis 2016; 67 (3, Suppl 1) S1-S305
    CrossrefPubMedGoogle Scholar
  • 6 Malekmakan L, Tadayon T, Roozbeh J, Sayadi M. End-stage renal disease in the middle east: a systematic review and meta-analysis. Iran J Kidney Dis 2018; 12 (04) 195-203
    PubMedGoogle Scholar
  • 7 Halle MP, Takongue C, Kengne AP, Kaze FF, Ngu KB. Epidemiological profile of patients with end stage renal disease in a referral hospital in Cameroon. BMC Nephrol 2015; 16 (01) 59
    CrossrefPubMedGoogle Scholar
  • 8 Malekmakan L, Malekmakan A, Daneshian A. et al Hypertension and diabetes remain the main causes of chronic renal failure in Fars Province, Iran 2013. Saudi J Kidney Dis Transplant 2016; 27 (02) 423-424
    CrossrefPubMedGoogle Scholar
  • 9 Barsoum RS. End-stage renal disease in the developing world. Artif Organs 2002; 26 (09) 735-736
    CrossrefPubMedGoogle Scholar
  • 10 Alashek WA, McIntyre CW, Taal MW. Epidemiology and aetiology of dialysis-treated end-stage kidney disease in Libya. BMC Nephrol 2012; 13 (01) 33
    CrossrefPubMedGoogle Scholar
  • 11 Saadi MG, El-Khashab SO, Mahmoud RMA. Renal transplantation experience in Cairo University hospitals. Egypt J Intern Med 2016; 28 (03) 116-122
    CrossrefGoogle Scholar
  • 12 Okafor UH. Kidney transplant in Nigeria: a single centre experience. Pan Afr Med J 2016; 25: 112
    CrossrefPubMedGoogle Scholar
  • 13 Perico N, Codreanu I, Schieppati A, Remuzzi G. Prevention of progression and remission/regression strategies for chronic renal diseases: can we do better now than five years ago?. Kidney Int Suppl 2005; (98) S21-S24
    CrossrefPubMedGoogle Scholar
  • 14 Aksoy N, Şelimen D. Investigation of the causes and risk factors of previous end-stage renal disease in kidney transplant recipients. Transplant Proc 2020; 52 (01) 140-145
    CrossrefPubMedGoogle Scholar
  • 15 Goleg FA, Kong NCT, Sahathevan R. Dialysis-treated end-stage kidney disease in Libya: epidemiology and risk factors. Int Urol Nephrol 2014; 46 (08) 1581-1587
    CrossrefPubMedGoogle Scholar
  • 16 Habas EM, Elamouri J, Rayani AA. Chronic kidney disease in Libya, Crosssectional Single Center Study. Epidemiol (Sunnyvale) 2016; 6 (264) 1165-2161
    Google Scholar
  • 17 Okafor UH. Transplant tourism among kidney transplant patients in Eastern Nigeria. BMC Nephrol 2017; 18 (01) 215
    CrossrefPubMedGoogle Scholar
  • 18 Hassanien AA, Al-Shaikh F, Vamos EP, Yadegarfar G, Majeed A. Epidemiology of end-stage renal disease in the countries of the Gulf Cooperation Council: a systematic review. JRSM Short Rep 2012; 3 (06) 38
    CrossrefPubMedGoogle Scholar
  • 19 Banaga ASI, Mohammed EB, Siddig RM. et al. Causes of end stage renal failure among haemodialysis patients in Khartoum State/Sudan. BMC Res Notes 2015; 8: 502
    CrossrefPubMedGoogle Scholar
  • 20 Kramer A, Pippias M, Noordzij M. et al. The European Renal Association - European Dialysis and Transplant Association (ERA-EDTA) Registry Annual Report 2015: a summary. Clin Kidney J 2018; 11 (01) 108-122
    CrossrefPubMedGoogle Scholar
  • 21 Merion RM, Goodrich NP, Johnson RJ. et al. Kidney transplant graft outcomes in 379 257 recipients on 3 continents. Am J Transplant 2018; 18 (08) 1914-1923
    CrossrefPubMedGoogle Scholar
  • 22 Faroque O, Islam SF, Ghosh KC, Hossain SZ. Live related kidney transplantation: experience of 360 patients in a tertiary care hospital of Bangladesh. Glob Acad J Med Sci 2023; 9036: 176-183
    CrossrefGoogle Scholar
  • 23 Hart A, Lentine KL, Smith JM. et al. OPTN/SRTR 2019 Annual Data Report: Kidney. Am J Transplant 2021; 21 (Suppl. 02) 21-137
    CrossrefPubMedGoogle Scholar