CC BY 4.0 · TH Open 2024; 08(01): e72-e80
DOI: 10.1055/s-0043-1777344
Review Article

Effect of Plasma Fibrinogen Levels on the Risk of Stroke in Patients with Type 2 Diabetes: A Systematic Review

Nicoline Daugaard
1   Unit for Thrombosis Research, Department of Clinical Biochemistry, Esbjerg Hospital, University Hospital of Southern Denmark, Esbjerg, Denmark
2   Department of Regional Health Research, University of Southern Denmark, Esbjerg, Denmark
3   Steno Diabetes Center Odense, Odense University Hospital, Odense, Denmark
,
Else-Marie Bladbjerg
1   Unit for Thrombosis Research, Department of Clinical Biochemistry, Esbjerg Hospital, University Hospital of Southern Denmark, Esbjerg, Denmark
2   Department of Regional Health Research, University of Southern Denmark, Esbjerg, Denmark
,
Moniek P.M. de Maat
1   Unit for Thrombosis Research, Department of Clinical Biochemistry, Esbjerg Hospital, University Hospital of Southern Denmark, Esbjerg, Denmark
2   Department of Regional Health Research, University of Southern Denmark, Esbjerg, Denmark
4   Department of Hematology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands
,
Anna-Marie Bloch Münster
1   Unit for Thrombosis Research, Department of Clinical Biochemistry, Esbjerg Hospital, University Hospital of Southern Denmark, Esbjerg, Denmark
2   Department of Regional Health Research, University of Southern Denmark, Esbjerg, Denmark
› Author Affiliations
Funding The work was supported by a grant from Steno Diabetes Center Odense, funded by the Novo Nordisk Foundation.

Abstract

Aims In this systematic review, we assessed the literature on the association between fibrinogen levels and stroke in patients with type 2 diabetes (T2D).

Methods MEDLINE and Ovid searches of English reports were performed on the relation between fibrinogen, stroke, and T2D in humans. The search was completed on May 4, 2023. Studies were eligible when T2D patients ≥18 years had stroke confirmed by computed tomography or magnetic resonance imaging, plasma fibrinogen was measured, and a relation between fibrinogen and stroke in T2D patients was reported. Screening of reports and extraction of data were done independently by two authors, and study quality was assessed by predefined issues.

Results Five studies of different designs were included. Three studies reported on significantly increased fibrinogen levels in T2D patients with stroke compared with T2D patients without stroke. Two studies did not observe a significant association between fibrinogen levels and stroke risk.

Conclusion No consistent association was observed between fibrinogen levels and risk of stroke in T2D patients. Due to differences in study design, low sample size, and poorly defined study participants, larger and better-defined studies are needed to elucidate the role of fibrinogen as a stroke risk marker in T2D patients.



Publication History

Received: 29 August 2023

Accepted: 01 November 2023

Article published online:
30 January 2024

© 2024. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution License, permitting unrestricted use, distribution, and reproduction so long as the original work is properly cited. (https://creativecommons.org/licenses/by/4.0/)

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