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CC BY 4.0 · Pharmaceutical Fronts 2023; 05(04): e274-e281
DOI: 10.1055/s-0043-1777299
Original Article

Durability of Photosensitizers in a Photo-oxidation Reaction in a Novel Oscillatory Baffled Photo Reactor

Jianhan Chen
1   Centre for Oscillatory Baffled Reactor Advancement, School of Engineering and Physical Sciences, Heriot–Watt University, Edinburgh, United Kingdom
,
Rohen Prinsloo
1   Centre for Oscillatory Baffled Reactor Advancement, School of Engineering and Physical Sciences, Heriot–Watt University, Edinburgh, United Kingdom
,
Xiongwei Ni
1   Centre for Oscillatory Baffled Reactor Advancement, School of Engineering and Physical Sciences, Heriot–Watt University, Edinburgh, United Kingdom
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Abstract

With the rapid development of novel photosensitizers/photocatalysts, photochemical transformation has become possible and practical. In this context, we report for the first time our work on testing and quantifying the durability and robustness of a heterogeneous photosensitizer, polymer-supported rose Bengal (Ps-RB) beads, in a model photo-oxidation reaction between α-terpinene and singlet oxygen (1O2). A novel photo reactor is used due to its capabilities of providing uniform suspensions of solid beads and uniform light distribution. We have proposed a methodology for quantifying the durability of the beads including the factors of loss of beads and the reduced product concentration. The results show that the durability of the Ps-RB beads has decreased by about 67% after five consecutive runs, and the half-life of the beads can be reached in less than 200 minutes. In addition, we have also identified the optimal bead mass in the novel photo reactor. Our work not only enriches the designs of new and better photosensitizers but also provides a comprehensive methodology for testing and validating photosensitizers.

Keywords

polymer-supported rose Bengal beads - durability - α-terpinene - oscillatory baffled photo reactor - ascaridole - singlet oxygen

Note

C α-T: concentration of α-Terpinene at time = t (mol L−1).


C α-T0: concentration of α-Terpinene at time = 0 (mol L−1).


f: oscillation frequency (Hz).


x o: oscillatory center-to-peak amplitude (m).




Publication History

Received: 18 September 2023

Accepted: 02 November 2023

Article published online:
13 December 2023

© 2023. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution License, permitting unrestricted use, distribution, and reproduction so long as the original work is properly cited. (https://creativecommons.org/licenses/by/4.0/)

Georg Thieme Verlag KG
Rüdigerstraße 14, 70469 Stuttgart, Germany

 

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