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Int J Angiol 2024; 33(01): 001-007
DOI: 10.1055/s-0043-1777258
Review Article

Current Evidence and Future Directions of Omega-3 Supplementation and Cardiovascular Disease Risk

Bambang Dwiputra 
1   Deptartment of Cardiology and Vascular Medicine, Faculty of Medicine, Universitas Indonesia - Harapan Kita National Cardiovascular Center, Jakarta, Indonesia
,
Anwar Santoso
1   Deptartment of Cardiology and Vascular Medicine, Faculty of Medicine, Universitas Indonesia - Harapan Kita National Cardiovascular Center, Jakarta, Indonesia
,
Budhi Setianto Purwowiyoto
1   Deptartment of Cardiology and Vascular Medicine, Faculty of Medicine, Universitas Indonesia - Harapan Kita National Cardiovascular Center, Jakarta, Indonesia
,
Basuni Radi
1   Deptartment of Cardiology and Vascular Medicine, Faculty of Medicine, Universitas Indonesia - Harapan Kita National Cardiovascular Center, Jakarta, Indonesia
,
Bashar Adi Wahyu Pandhita
1   Deptartment of Cardiology and Vascular Medicine, Faculty of Medicine, Universitas Indonesia - Harapan Kita National Cardiovascular Center, Jakarta, Indonesia
,
Serlie Fatrin
1   Deptartment of Cardiology and Vascular Medicine, Faculty of Medicine, Universitas Indonesia - Harapan Kita National Cardiovascular Center, Jakarta, Indonesia
,
Ade Meidian Ambari
1   Deptartment of Cardiology and Vascular Medicine, Faculty of Medicine, Universitas Indonesia - Harapan Kita National Cardiovascular Center, Jakarta, Indonesia
› Author Affiliations Funding None.
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Abstract

Omega-3 supplementation has a controversial role in the secondary prevention of cardiovascular diseases. Despite large clinical trials published over the years, the evidence of omega-3 in preventing cardiovascular diseases, especially coronary heart disease, is still inconclusive. However, recent clinical trials using higher dose of omega-3 or highly purified esters of omega-3 shows promising result, with reduction in cardiovascular death and incidence of cardiovascular disease. This review aims to summarize the possible mechanism of omega-3 in preventing cardiovascular disease and future directions of research regarding the benefit of omega-3 in cardiovascular disease.

Keywords

atherosclerosis - cardiovascular disease - prevention - fatty acid - omega-3 - eicosapentaenoic acid

Authors' Contributions

B.D. and A.S. contributed to study conceptualization and original draft writing. B.S.P. and B.R. contributed as supervisors and manuscript reviewer. D.R.D. and A.M.A. contributed in providing relevant studies and research methodology. B.A.W.P. and S.F. provided relevant figures and tables for the review.




Publication History

Article published online:
24 November 2023

© 2023. International College of Angiology. This article is published by Thieme.

Thieme Medical Publishers, Inc.
333 Seventh Avenue, 18th Floor, New York, NY 10001, USA

 

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