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Semin Thromb Hemost 2024; 50(04): 609-619
DOI: 10.1055/s-0043-1777071
Review Article

Role of Platelets in Rheumatic Chronic Autoimmune Inflammatory Diseases

Martin Jozef Péč
1   Department of Internal Medicine I, Jessenius Faculty of Medicine in Martin, Comenius University in Bratislava, Martin, Slovak Republic
,
Jakub Jurica
1   Department of Internal Medicine I, Jessenius Faculty of Medicine in Martin, Comenius University in Bratislava, Martin, Slovak Republic
,
Monika Péčová
2   Oncology Centre, Teaching Hospital Martin, Martin, Slovak Republic
3   Department of Hematology and Transfusiology, National Centre of Hemostasis and Thrombosis, Jessenius Faculty of Medicine in Martin, Comenius University in Bratislava, Martin, Slovak Republic
,
Jakub Benko
1   Department of Internal Medicine I, Jessenius Faculty of Medicine in Martin, Comenius University in Bratislava, Martin, Slovak Republic
4   Department of Cardiology, Teaching Hospital Nitra, Nitra, Slovak Republic
,
Juraj Sokol
3   Department of Hematology and Transfusiology, National Centre of Hemostasis and Thrombosis, Jessenius Faculty of Medicine in Martin, Comenius University in Bratislava, Martin, Slovak Republic
,
Tomáš Bolek
1   Department of Internal Medicine I, Jessenius Faculty of Medicine in Martin, Comenius University in Bratislava, Martin, Slovak Republic
,
Marek Samec
5   Department of Medical Biology, Jessenius Faculty of Medicine in Martin, Comenius University in Bratislava, Martin, Slovak Republic
,
Tatiana Hurtová
6   Department of Dermatovenerology, Jessenius Faculty of Medicine in Martin, Comenius University in Bratislava, Martin, Slovak Republic
7   Department of Infectology and Travel Medicine, Jessenius Faculty of Medicine in Martin, Comenius University in Bratislava, Martin, Slovak Republic
,
Peter Galajda
1   Department of Internal Medicine I, Jessenius Faculty of Medicine in Martin, Comenius University in Bratislava, Martin, Slovak Republic
,
Matej Samoš
1   Department of Internal Medicine I, Jessenius Faculty of Medicine in Martin, Comenius University in Bratislava, Martin, Slovak Republic
8   Division of Acute and Interventional Cardiology, Department of Cardiology and Angiology II, Mid-Slovakian Institute of Heart and Vessel Diseases (SÚSCCH, a.s.), Banská Bystrica, Slovak Republic
,
Marián Mokáň
1   Department of Internal Medicine I, Jessenius Faculty of Medicine in Martin, Comenius University in Bratislava, Martin, Slovak Republic
› Author Affiliations Funding This study was supported by the research project of Slovak Research and Development Agency (APVV) 16-0020, by the research project of the Research Agency of Slovak Ministry of Education, Science, and Sports (VEGA) 1/0090/20, and by the research project of Comenius University (UK/318/2022).
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Abstract

Platelets are essential in maintaining blood homeostasis and regulating several inflammatory processes. They constantly interact with immune cells, have immunoregulatory functions, and can affect, through immunologically active substances, endothelium, leukocytes, and other immune response components. In reverse, inflammatory and immune processes can activate platelets, which might be significant in autoimmune disease progression and arising complications. Thus, considering this interplay, targeting platelet activity may represent a new approach to treatment of autoimmune diseases. This review aims to highlight the role of platelets in the pathogenic mechanisms of the most frequent chronic autoimmune inflammatory diseases to identify gaps in current knowledge and to provide potential new targets for medical interventions.

Keywords

psoriasis - systemic sclerosis - systemic lupus erythematosus - chronic inflammatory arthritis

Data Availability

All the source data are available at the corresponding author upon a reasonable request.




Publication History

Article published online:
28 November 2023

© 2023. Thieme. All rights reserved.

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