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CC BY-NC-ND 4.0 · South Asian J Cancer 2024; 13(02): 099-105
DOI: 10.1055/s-0043-1776789
Original Article
Gastrointestinal Cancer

Colorectal Origin: A Marker of Favorable Outcome in Krukenberg Tumor? Results from Clinical and Prognostic Analysis

Purnima Thakur
1   Department of Radiotherapy, Indira Gandhi Medical College, Shimla, Himachal Pradesh, India
,
Mukesh Sharma 
2   Department of Radiotherapy, Dr. Yashwant Singh Parmar Government Medical College, Nahan, Sirmaur, Himachal Pradesh, India
,
Ashish Chauhan
3   Department of Gastroenterology, Indira Gandhi Medical College, Shimla, Himachal Pradesh, India
,
Kapil M. Pal
1   Department of Radiotherapy, Indira Gandhi Medical College, Shimla, Himachal Pradesh, India
,
Shabnam Thakur
1   Department of Radiotherapy, Indira Gandhi Medical College, Shimla, Himachal Pradesh, India
,
Manish Gupta
1   Department of Radiotherapy, Indira Gandhi Medical College, Shimla, Himachal Pradesh, India
,
Shilpa Kaushal
1   Department of Radiotherapy, Indira Gandhi Medical College, Shimla, Himachal Pradesh, India
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Abstract

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Purnima Thakur

This study aimed to identify the prognostic factors affecting the survival of patients suffering from Krukenberg tumor (KT) and also to determine the survival in these patients. A retrospective review of patients diagnosed with KT between January 2015 and December 2021 was conducted at a tertiary cancer center. Clinicopathological variables were scrutinized, and survival analysis was performed. Thirty-six patients were enrolled in this study. The median age at diagnosis was 48 years (ranging from 22 to 71 years). The median overall survival (OS) was 9.9 months (95% confidence interval [CI]: 6.6 to 13 months). The mean OS for tumors originating in the colorectal region was longer compared to that for tumors of other sites (15.4 vs. 9 months, respectively; p = 0.048). In univariate analysis, patients who received chemotherapy had better survival, while those presenting with ascites had a poor prognosis. No correlation was observed between age, menstrual status, bilaterality, size of ovarian metastases, extent of metastatic disease, metastasectomy, and survival. Multivariate Cox regression analysis showed that chemotherapy predicted a favorable survival outcome (hazard ratio [HR] = 0.200, 95% CI: 0.046–0.877, p-value = 0.033). KT is an aggressive tumor with a median OS of less than a year. Chemotherapy may improve survival. Patients with a primary tumor in the colorectal region have a better outcome, while those presenting with ascites indicate a poor prognosis.

Keywords

Krukenberg tumor - prognostic factors - survival - chemotherapy


Publication History

Article published online:
12 February 2024

© 2024. MedIntel Services Pvt Ltd. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/)

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