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CC BY-NC-ND 4.0 · Indian J Plast Surg 2023; 56(05): 405-412
DOI: 10.1055/s-0043-1774385
Systematic Review

Histological Compatibility in Distal Neurotizations: A Systematic Review

Cristina Schmitt Cavalheiro 
1   Department of Hand, Wrist and Microsurgery, Instituto Vita, São Paulo, SP, Brazil
2   Institute of Orthopedic and Traumatology, Faculdade de Medicina, Universidade de Sâo Paulo, São Paulo, SP, Brazil
,
João Carlos Nakamoto 
1   Department of Hand, Wrist and Microsurgery, Instituto Vita, São Paulo, SP, Brazil
,
Teng Hsiang Wei 
2   Institute of Orthopedic and Traumatology, Faculdade de Medicina, Universidade de Sâo Paulo, São Paulo, SP, Brazil
,
Luiz Sorrenti 
1   Department of Hand, Wrist and Microsurgery, Instituto Vita, São Paulo, SP, Brazil
,
Erick Yoshio Wataya 
1   Department of Hand, Wrist and Microsurgery, Instituto Vita, São Paulo, SP, Brazil
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Abstract

Considering the importance of defining the minimum number of axons between recipient and donor branches, that is, the definition of histological compatibility in distal neurotizations for the success of the procedure and the surgeon's freedom to choose individualized strategies for each patient, this systematic review was conducted to find out the most recent studies on the subject. The objective of this systematic review was to determine the importance of the number of axons and the relationship between axon counts in the donor and recipient nerves in the success of nerve transfer. A literature review was performed on five international databases: Web of Science, Scopus, Wiley (Cochrane Database), Embase, and PubMed. The Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines were followed (2020 version), a guide designed to guide the elaboration of systematic literature reviews. One hundred and fifty-seven studies were found, and 23 were selected based on the eligibility criteria. The articles presented were conclusive in determining the importance of the number of axons in the success of nerve transfer. Still, the relationship between the number of axons in the donor and recipient nerves seems more relevant in the success of transfers and is not always explored by the authors. The review of the articles has provided compelling evidence that the number of axons is a critical determinant of the success of nerve transfer procedures. However, the relationship between the number of axons in the donor nerve and that in the recipient nerve appears to be even more crucial for successful transfers, a factor that is not always adequately explored by authors in the existing literature.

Level of evidence: Level IV, therapeutic study

Keywords

axon count - nerve transfer - systematic review - donor and recipient nerve.

Note

This study was performed at the Instituto Vita, São Paulo, SP, Brazil.


Author Contributions

C.S.C. wrote the original draft of the article, participated in the review, editing process data curation, conducting the research; investigation process; and approval of the final article. J.C.N. contributed to the methodology, and participated in the review, editing process, supervision, and approval of the final article. T.H.W. participated in the review, supervision, and approval of the final article. L.S. contributed to the editing process, validation, and approval of the final article. E.Y.W. contributed to the editing process, validation, and approval of the final article.


Supplementary Material



Publikationsverlauf

Artikel online veröffentlicht:
25. September 2023

© 2023. Association of Plastic Surgeons of India. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/)

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