Planta Med 2023; 89(14): 1384
DOI: 10.1055/s-0043-1774145
Abstracts
Tuesday 4th July 2023 | Poster Session II
Phytopharmacology II – Metabolism; Diabetes; Obesity; Gut

Alpha-Glucosidase inhibitory activity of phenolic compounds from the stems of Caesalpinia decapetala var. japonica

Thi Thanh Le
1   Daegu Catholic University, Hayang-eup Hayang-ri, 13-13, Kyeongsan-sii, South Korea
,
Manh Tuan Ha
1   Daegu Catholic University, Hayang-eup Hayang-ri, 13-13, Kyeongsan-sii, South Korea
,
Jeong Ah Kim
2   College of Pharmacy, Research Institute of Pharmaceutical Sciences, Kyungpook National University, Daegu, South Korea
,
Byung Sun Min
1   Daegu Catholic University, Hayang-eup Hayang-ri, 13-13, Kyeongsan-sii, South Korea
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To obtain antidiabetic active compounds from the natural sources, 14 compounds were isolated from the stems of Caesalpinia decapetala var. japonica. Their structures were elucidated based on a comparison of their physicochemical and spectral data with those of literature. To the best of our knowledge, this represents the first isolation of compounds 3, 4, 8, 9, and 10 from C. decapetala and compounds 13 and 14 from the Caesalpinia genus. All the isolated compounds were evaluated for their inhibitory effect against the α-glucosidase enzyme. Among them, two flavonols (1 and 9), one chalcone (6), and one homoisoflavanone (7) exhibited an inhibitory effect on α-glucosidase action with an IC50 range of 5.08 – 15.01 µM, stronger than that of the positive control (acarbose, IC50=152.22 μM). Kinetic analysis revealed that compounds 1 and 9 showed non-competitive α-glucosidase inhibition, while the inhibition type was mixed for compounds 6 and 7 ([Fig. 1]) [1] [2].

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Fig. 1 Chemical structures of compounds 1-14 from C. decapetala var. japonica.


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Artikel online veröffentlicht:
16. November 2023

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  • References

  • 1 Le TT, Ha MT, Hoang LM., Vu NK., Kim JA, Min BS.. α-Glucosidase Inhibitory Activity of Phenolic Compounds Isolated from the Stems of Caesalpinia decapetala var. japonica. Natural Product Sciences 2022; 28 (03) 143-152
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