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CC BY-NC-ND 4.0 · Journal of Diabetes and Endocrine Practice 2023; 06(03): 118-125
DOI: 10.1055/s-0043-1771447
Review Article

Effect of Intermittent Fasting versus Continuous Caloric Restriction on Body Weight and Metabolic Parameters in Adults with Overweight or Obesity: A Narrative Review

Jessica Abou Chaaya   *
1   Division of Endocrinology, Department of Internal Medicine, American University of Beirut Medical Center, Faculty of Medicine, Beirut, Lebanon
,
Jana Dib El Jalbout   *
2   Gilbert and Rose-Marie Chagoury School of Medicine, Lebanese American University, Byblos, Lebanon
,
Mona P. Nasrallah
1   Division of Endocrinology, Department of Internal Medicine, American University of Beirut Medical Center, Faculty of Medicine, Beirut, Lebanon
› Author Affiliations Funding and Sponsorship None.
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Abstract

Obesity and type 2 diabetes have reached epidemic proportions worldwide, including the Middle East and North Africa region. Intermittent fasting (IF) has been increasingly used to manage overweight/obesity and its metabolic complications. Physiologically, IF shifts the body's metabolism into ketosis (the metabolic switch) and induces cellular changes, which have a theoretical benefit over and above continuous caloric restriction (CCR). In this narrative overview of IF, the focus is on summarizing studies that compare IF to CCR in adults with overweight or obesity. The most commonly practiced types of IF (5:2, the alternate day fast, and the time-restricted eating) were included. Nine studies of 1-year duration or longer, with weight loss as the primary outcome, were summarized. The effect on body weight and improved metabolic parameters such as blood pressure, glycemic indicators, and lipid profile are described. Overall, IF was well tolerated and effective for weight loss in a manner comparable to CCR. The benefits were similar among adults with type 2 diabetes. There were no additional metabolic effects or benefits over and above CCR. However, more studies are needed to address specific details of IF, such as the type and timing of fasting and its application to different populations. In conclusion, IF is safe and beneficial for weight loss in adults with overweight/obesity with or without diabetes. It can be used as an alternative to CCR.

Keywords

intermittent fasting - time-restricted eating - caloric restriction - obesity - weight loss

Compliance with Ethical Principles

No ethical approval is required for review article types of studies.


Authors' Contribution

J.A. and J.J. each wrote significant components of the manuscript. J.J. reviewed the literature and extracted the data into tables and figures. M.N. was responsible for the manuscript's concept, reviewing, and editing.


* Equal contributions




Publication History

Article published online:
29 September 2023

© 2023. Gulf Association of Endocrinology and Diabetes (GAED). This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/)

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