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CC BY-NC-ND 4.0 · Sleep Sci 2023; 16(02): 248-255
DOI: 10.1055/s-0043-1770811
Review Article

Association between 5-Hydroxytryptamine Receptor 2A Gene (rs6313 and rs4941573) Polymorphism and Sleep Bruxism: A Meta-analysis

Paria Motahari 
1   Department of Oral and Maxillofacial Medicine, Faculty of Dentistry, Tabriz university of Medical Sciences, Tabriz, East Azarbaijan, Iran
,
Katayoun Katebi 
1   Department of Oral and Maxillofacial Medicine, Faculty of Dentistry, Tabriz university of Medical Sciences, Tabriz, East Azarbaijan, Iran
,
Fatemeh Pournaghi-Azar 
2   Department of Restorative Dentistry, Faculty of Dentistry, Tabriz University of Medical Sciences, Tabriz, East Azarbaijan, Iran
,
Masoumeh Jabbarzadeh 
1   Department of Oral and Maxillofacial Medicine, Faculty of Dentistry, Tabriz university of Medical Sciences, Tabriz, East Azarbaijan, Iran
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Abstract

Genetic factors may influence sleep bruxism's pathogenesis. Even though the association between the, 5-hydroxytryptamine 2A (5-HTR2A) serotonin receptor gene polymorphism and sleep bruxism has been investigated, inconsistent findings have been discovered. As a result, meta-analysis was performed to gather complete results on this topic. PubMed, Web of Science, Embase, and Scopus databases were searched for all papers containing English abstracts until April 2022. Medical Subject Heading (MESH) terms plus unrestricted keywords were used in the searches. The Cochrane test and the I2 statistic were used to determine the heterogeneity percentage in numerous researches. Comprehensive Meta-analysis v.2.0 software was used to conduct the analyses. Five properly fitting papers were chosen for meta-analysis from the 39 articles acquired during the initial search. The meta-analysis revealed that the 5-HTR2A polymorphism has no link with sleep bruxism susceptibility across the models studied (P-Value > 0.05). The combined odds ratio analysis revealed no statistically significant association between the 5-HTR2A gene polymorphism with sleep bruxism. Nonetheless, these findings require confirmation through researches with large sample sizes. Identifying genetic markers for sleep bruxism may help clarify and expand our current knowledge of bruxism physiopathology.

Keywords

Polymorphism - Genetic - Sleep Bruxism - Receptors - Serotonin - Meta-Analysis

Source(s) of support

None.




Publikationsverlauf

Artikel online veröffentlicht:
06. Juli 2023

© 2023. Brazilian Sleep Association. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/)

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