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DOI: 10.1055/s-0043-1770342
Control of Breathing
Funding Grant support for this study was provided by NHLBI.![](https://www.thieme-connect.de/media/srccm/202305/lookinside/thumbnails/10-1055-s-0043-1770342_230509-1.jpg)
Abstract
Substantial advances have been made recently into the discovery of fundamental mechanisms underlying the neural control of breathing and even some inroads into translating these findings to treating breathing disorders. Here, we review several of these advances, starting with an appreciation of the importance of V̇A:V̇CO2:PaCO2 relationships, then summarizing our current understanding of the mechanisms and neural pathways for central rhythm generation, chemoreception, exercise hyperpnea, plasticity, and sleep-state effects on ventilatory control. We apply these fundamental principles to consider the pathophysiology of ventilatory control attending hypersensitized chemoreception in select cardiorespiratory diseases, the pathogenesis of sleep-disordered breathing, and the exertional hyperventilation and dyspnea associated with aging and chronic diseases. These examples underscore the critical importance that many ventilatory control issues play in disease pathogenesis, diagnosis, and treatment.
Keywords
chemoreception - exercise hyperpnea - plasticity - sleep-disordered breathing - respiratory rhythm generation - exertional dyspnea - COPD - CHF - agingPublikationsverlauf
Artikel online veröffentlicht:
11. Juli 2023
© 2023. Thieme. All rights reserved.
Thieme Medical Publishers, Inc.
333 Seventh Avenue, 18th Floor, New York, NY 10001, USA
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