Subscribe to RSS
Download PDF
DOI: 10.1055/s-0043-1769804
Steroids and Traumatic Brain Injury: Time to Revisit?
Authors
Funding None.
Secondary insults such as brain edema are an important and relatively common event occurring after traumatic brain injury (TBI), leading to consequences such as raised intracranial pressure and cerebral herniation. Further, posttraumatic inflammatory changes are known to significantly contribute to neuronal dysfunction.
Authors' Contributions
G. Lakshmi Prasad designed and drafted the manuscript. Deepak Agarwal revised the manuscript and gave final approval.
Publication History
Article published online:
27 June 2023
© 2023. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution License, permitting unrestricted use, distribution, and reproduction so long as the original work is properly cited. (https://creativecommons.org/licenses/by/4.0/)
Thieme Medical and Scientific Publishers Pvt. Ltd.
A-12, 2nd Floor, Sector 2, Noida-201301 UP, India
-
References
- 1 Alderson P, Roberts I. Corticosteroids in acute traumatic brain injury: systematic review of randomised controlled trials. BMJ 1997; 314 (7098): 1855-1859
- 2 Task Force of the American Association of Neurological Surgeons and Joint Section in Neurotrauma and Critical Care. Guidelines for the Management of Severe Head Injury. New York: Brain Trauma Foundation; 1995
- 3 Bracken MB, Shepard MJ, Collins WF. et al. A randomized, controlled trial of methylprednisolone or naloxone in the treatment of acute spinal-cord injury. Results of the Second National Acute Spinal Cord Injury Study. N Engl J Med 1990; 322 (20) 1405-1411
- 4 Roberts I, Yates D, Sandercock P. et al; CRASH trial collaborators. Effect of intravenous corticosteroids on death within 14 days in 10008 adults with clinically significant head injury (MRC CRASH trial): randomised placebo-controlled trial. Lancet 2004; 364 (9442): 1321-1328
- 5 Prasad GL. Steroids for delayed cerebral edema after traumatic brain injury. Surg Neurol Int 2021; 12: 46
- 6 Coutinho AE, Chapman KE. The anti-inflammatory and immunosuppressive effects of glucocorticoids, recent developments and mechanistic insights. Mol Cell Endocrinol 2011; 335 (01) 2-13
- 7 Donkin JJ, Vink R. Mechanisms of cerebral edema in traumatic brain injury: therapeutic developments. Curr Opin Neurol 2010; 23 (03) 293-299
- 8 Nimmo AJ, Cernak I, Heath DL, Hu X, Bennett CJ, Vink R. Neurogenic inflammation is associated with development of edema and functional deficits following traumatic brain injury in rats. Neuropeptides 2004; 38 (01) 40-47
- 9 Moll A, Lara M, Pomar J. et al. Effects of dexamethasone in traumatic brain injury patients with pericontusional vasogenic edema: a prospective-observational DTI-MRI study. Medicine (Baltimore) 2020; 99 (43) e22879