Semin Neurol 2023; 43(02): 312-320
DOI: 10.1055/s-0043-1768714
Review Article

Neurorecovery after Critical COVID-19 Illness

Haitham Alabsi
1   Division of Neurocritical Care, Department of Neurology, Massachusetts General Hospital, Boston, Massachusetts
,
Kristi Emerson
1   Division of Neurocritical Care, Department of Neurology, Massachusetts General Hospital, Boston, Massachusetts
2   Department of Neurology, Center for Neurotechnology and Neurorecovery, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts
,
1   Division of Neurocritical Care, Department of Neurology, Massachusetts General Hospital, Boston, Massachusetts
2   Department of Neurology, Center for Neurotechnology and Neurorecovery, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts
› Author Affiliations

Abstract

With the hundreds of millions of people worldwide who have been, and continue to be, affected by pandemic coronavirus disease (COVID-19) and its chronic sequelae, strategies to improve recovery and rehabilitation from COVID-19 are critical global public health priorities. Neurologic complications have been associated with acute COVID-19 infection, usually in the setting of critical COVID-19 illness. Neurologic complications are also a core feature of the symptom constellation of long COVID and portend poor outcomes. In this article, we review neurologic complications and their mechanisms in critical COVID-19 illness and long COVID. We focus on parallels with neurologic disease associated with non-COVID critical systemic illness. We conclude with a discussion of how recent findings can guide both neurologists working in post-acute neurologic rehabilitation facilities and policy makers who influence neurologic resource allocation.



Publication History

Article published online:
11 May 2023

© 2023. Thieme. All rights reserved.

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  • References

  • 1 Gebru AA, Birhanu T, Wendimu E. et al. Global burden of COVID-19: situational analysis and review. Hum Antibodies 2021; 29 (02) 139-148
  • 2 Pei S, Yamana TK, Kandula S, Galanti M, Shaman J. Burden and characteristics of COVID-19 in the United States during 2020. Nature 2021; 598 (7880): 338-341
  • 3 Huang C, Wang Y, Li X. et al. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. Lancet 2020; 395 (10223): 497-506
  • 4 Yang X, Yu Y, Xu J. et al. Clinical course and outcomes of critically ill patients with SARS-CoV-2 pneumonia in Wuhan, China: a single-centered, retrospective, observational study. Lancet Respir Med 2020; 8 (05) 475-481
  • 5 Wang D, Hu B, Hu C. et al. Clinical characteristics of 138 hospitalized patients with 2019 novel coronavirus-infected pneumonia in Wuhan, China. JAMA 2020; 323 (11) 1061-1069
  • 6 Richardson S, Hirsch JS, Narasimhan M. et al; The Northwell COVID-19 Research Consortium. Presenting characteristics, comorbidities, and outcomes among 5700 patients hospitalized with COVID-19 in the New York City area. JAMA 2020; 323 (20) 2052-2059
  • 7 Fernández-de-Las-Peñas C, Palacios-Ceña D, Gómez-Mayordomo V, Cuadrado ML, Florencio LL. Defining post-COVID symptoms (post-acute COVID, long COVID, persistent post-COVID): an integrative classification. Int J Environ Res Public Health 2021; 18 (05) 18
  • 8 Nalbandian A, Sehgal K, Gupta A. et al. Post-acute COVID-19 syndrome. Nat Med 2021; 27 (04) 601-615
  • 9 Parker AM, Brigham E, Connolly B. et al. Addressing the post-acute sequelae of SARS-CoV-2 infection: a multidisciplinary model of care. Lancet Respir Med 2021; 9 (11) 1328-1341
  • 10 Dale L. Neurological complications of COVID-19: a review of the literature. Cureus 2022; 14 (08) e27633
  • 11 Pleasure SJ, Green AJ, Josephson SA. The spectrum of neurologic disease in the severe acute respiratory syndrome coronavirus 2 pandemic infection: neurologists move to the frontlines. JAMA Neurol 2020; 77 (06) 679-680
  • 12 Mao L, Jin H, Wang M. et al. Neurologic manifestations of hospitalized patients with coronavirus disease 2019 in Wuhan, China. JAMA Neurol 2020; 77 (06) 683-690
  • 13 Yassin A, Nawaiseh M, Shaban A. et al. Neurological manifestations and complications of coronavirus disease 2019 (COVID-19): a systematic review and meta-analysis. BMC Neurol 2021; 21 (01) 138
  • 14 Frontera JA, Sabadia S, Lalchan R. et al. A prospective study of neurologic disorders in hospitalized patients with COVID-19 in New York City. Neurology 2021; 96 (04) e575-e586
  • 15 Ellul MA, Benjamin L, Singh B. et al. Neurological associations of COVID-19. Lancet Neurol 2020; 19 (09) 767-783
  • 16 Liotta EM, Batra A, Clark JR. et al. Frequent neurologic manifestations and encephalopathy-associated morbidity in COVID-19 patients. Ann Clin Transl Neurol 2020; 7 (11) 2221-2230
  • 17 Koralnik IJ, Tyler KL. COVID-19: a global threat to the nervous system. Ann Neurol 2020; 88 (01) 1-11
  • 18 Dimitriadis K, Meis J, Neugebauer H. et al; IGNITE Study Group. Neurologic manifestations of COVID-19 in critically ill patients: results of the prospective multicenter registry PANDEMIC. Crit Care 2022; 26 (01) 217
  • 19 Fan S, Xiao M, Han F. et al. Neurological manifestations in critically ill patients with COVID-19: a retrospective study. Front Neurol 2020; 11: 806
  • 20 Abenza-Abildúa MJ, Ramírez-Prieto MT, Moreno-Zabaleta R. et al. Neurological complications in critical patients with COVID-19 [in Spanish]. Neurologia (Engl Ed) 2020; 35 (09) 621-627
  • 21 Battaglini D, Santori G, Chandraptham K. et al. Neurological complications and noninvasive multimodal neuromonitoring in critically ill mechanically ventilated COVID-19 patients. Front Neurol 2020; 11: 602114
  • 22 Flinspach AN, Booke H, Zacharowski K, Balaban Ü, Herrmann E, Adam EH. High sedation needs of critically ill COVID-19 ARDS patients - a monocentric observational study. PLoS One 2021; 16 (07) e0253778
  • 23 Abdo WF, Broerse CI, Grady BP. et al. Prolonged unconsciousness following severe COVID-19. Neurology 2021; 96 (10) e1437-e1442
  • 24 Fischer D, Snider SB, Barra ME. et al. Disorders of consciousness associated with COVID-19: a prospective multimodal study of recovery and brain connectivity. Neurology 2022; 98 (03) e315-e325
  • 25 Hernández-Fernández F, Sandoval Valencia H, Barbella-Aponte RA. et al. Cerebrovascular disease in patients with COVID-19: neuroimaging, histological and clinical description. Brain 2020; 143 (10) 3089-3103
  • 26 Kaptein FHJ, Stals MAM, Grootenboers M. et al; Dutch COVID & Thrombosis Coalition. Incidence of thrombotic complications and overall survival in hospitalized patients with COVID-19 in the second and first wave. Thromb Res 2021; 199: 143-148
  • 27 Yamakawa M, Kuno T, Mikami T, Takagi H, Gronseth G. Clinical characteristics of stroke with COVID-19: a systematic review and meta-analysis. J Stroke Cerebrovasc Dis 2020; 29 (12) 105288
  • 28 Chou SH, Beghi E, Helbok R. et al; GCS-NeuroCOVID Consortium and ENERGY Consortium. Global incidence of neurological manifestations among patients hospitalized with COVID-19 - a report for the GCS-NeuroCOVID Consortium and the ENERGY Consortium. JAMA Netw Open 2021; 4 (05) e2112131
  • 29 Merkler AE, Parikh NS, Mir S. et al. Risk of ischemic stroke in patients with coronavirus disease 2019 (COVID-19) vs patients with influenza. JAMA Neurol 2020; 77 (11) 1-7
  • 30 Klok FA, Kruip MJHA, van der Meer NJM. et al. Incidence of thrombotic complications in critically ill ICU patients with COVID-19. Thromb Res 2020; 191: 145-147
  • 31 Cho SM, Premraj L, Fanning J. et al. Ischemic and hemorrhagic stroke among critically ill patients with coronavirus disease 2019: an International Multicenter Coronavirus Disease 2019 Critical Care Consortium Study. Crit Care Med 2021; 49 (12) e1223-e1233
  • 32 Robinson CP, Busl KM. Severe COVID-19 and stroke-another piece in the Puzzle. Crit Care Med 2021; 49 (12) 2160-2164
  • 33 Dixon L, McNamara C, Gaur P. et al. Cerebral microhaemorrhage in COVID-19: a critical illness related phenomenon?. Stroke Vasc Neurol 2020; 5 (04) 315-322
  • 34 Suh J, Amato AA. Neuromuscular complications of coronavirus disease-19. Curr Opin Neurol 2021; 34 (05) 669-674
  • 35 Bagnato S, Ferraro M, Boccagni C. et al. COVID-19 neuromuscular involvement in post-acute rehabilitation. Brain Sci 2021; 11 (12) 11
  • 36 Frithiof R, Rostami E, Kumlien E. et al. Critical illness polyneuropathy, myopathy and neuronal biomarkers in COVID-19 patients: a prospective study. Clin Neurophysiol 2021; 132 (07) 1733-1740
  • 37 Dodig D, Tarnopolsky MA, Margeta M, Gordon K, Fritzler MJ, Lu JQ. COVID-19-associated critical illness myopathy with direct viral effects. Ann Neurol 2022; 91 (04) 568-574
  • 38 Cabañes-Martínez L, Villadóniga M, González-Rodríguez L. et al. Neuromuscular involvement in COVID-19 critically ill patients. Clin Neurophysiol 2020; 131 (12) 2809-2816
  • 39 Tankisi H. Critical illness myopathy and polyneuropathy in COVID-19: Is it a distinct entity?. Clin Neurophysiol 2021; 132 (07) 1716-1717
  • 40 Huang C, Huang L, Wang Y. et al. 6-month consequences of COVID-19 in patients discharged from hospital: a cohort study. Lancet 2021; 397 (10270): 220-232
  • 41 Zhang X, Wang F, Shen Y. et al. Symptoms and health outcomes among survivors of COVID-19 infection 1 year after discharge from hospitals in Wuhan, China. JAMA Netw Open 2021; 4 (09) e2127403
  • 42 Heesakkers H, van der Hoeven JG, Corsten S. et al. Clinical outcomes among patients with 1-year survival following intensive care unit treatment for COVID-19. JAMA 2022; 327 (06) 559-565
  • 43 Schandl A, Hedman A, Lyngå P. et al. Long-term consequences in critically ill COVID-19 patients: a prospective cohort study. Acta Anaesthesiol Scand 2021; 65 (09) 1285-1292
  • 44 González J, Zuil M, Benítez ID. et al. One year overview and follow-up in a post-COVID consultation of critically ill patients. Front Med (Lausanne) 2022; 9: 897990
  • 45 Neville TH, Hays RD, Tseng CH. et al. Survival after severe COVID-19: long-term outcomes of patients admitted to an intensive care unit. J Intensive Care Med 2022; 37 (08) 1019-1028
  • 46 McPeake J, Shaw M, MacTavish P. et al. Long-term outcomes following severe COVID-19 infection: a propensity matched cohort study. BMJ Open Respir Res 2021; 8 (01) 8
  • 47 Datta SD, Talwar A, Lee JT. A proposed framework and timeline of the spectrum of disease due to SARS-CoV-2 infection: illness beyond acute infection and public health implications. JAMA 2020; 324 (22) 2251-2252
  • 48 Davis HE, Assaf GS, McCorkell L. et al. Characterizing long COVID in an international cohort: 7 months of symptoms and their impact. EClinicalMedicine 2021; 38: 101019
  • 49 Sukocheva OA, Maksoud R, Beeraka NM. et al. Analysis of post COVID-19 condition and its overlap with myalgic encephalomyelitis/chronic fatigue syndrome. J Adv Res 2022; 40: 179-196
  • 50 Shouman K, Vanichkachorn G, Cheshire WP. et al. Autonomic dysfunction following COVID-19 infection: an early experience. Clin Auton Res 2021; 31 (03) 385-394
  • 51 Goodman BP, Khoury JA, Blair JE, Grill MF. COVID-19 dysautonomia. Front Neurol 2021; 12: 624968
  • 52 Barizien N, Le Guen M, Russel S, Touche P, Huang F, Vallée A. Clinical characterization of dysautonomia in long COVID-19 patients. Sci Rep 2021; 11 (01) 14042
  • 53 Su Y, Yuan D, Chen DG. et al; ISB-Swedish COVID-19 Biobanking Unit. Multiple early factors anticipate post-acute COVID-19 sequelae. Cell 2022; 185 (05) 881-895.e20
  • 54 Sudre CH, Murray B, Varsavsky T. et al. Attributes and predictors of long COVID. Nat Med 2021; 27 (04) 626-631
  • 55 Goërtz YMJ, Van Herck M, Delbressine JM. et al. Persistent symptoms 3 months after a SARS-CoV-2 infection: the post-COVID-19 syndrome?. ERJ Open Res 2020; 6 (04) 6
  • 56 Iadecola C, Anrather J, Kamel H. Effects of COVID-19 on the nervous system. Cell 2020; 183 (01) 16-27.e1
  • 57 Hoffmann M, Kleine-Weber H, Schroeder S. et al. SARS-CoV-2 cell entry depends on ACE2 and TMPRSS2 and is blocked by a clinically proven protease inhibitor. Cell 2020; 181 (02) 271-280.e8
  • 58 Hamming I, Timens W, Bulthuis ML, Lely AT, Navis G, van Goor H. Tissue distribution of ACE2 protein, the functional receptor for SARS coronavirus. A first step in understanding SARS pathogenesis. J Pathol 2004; 203 (02) 631-637
  • 59 Bergmann CC, Lane TE, Stohlman SA. Coronavirus infection of the central nervous system: host-virus stand-off. Nat Rev Microbiol 2006; 4 (02) 121-132
  • 60 Lekgwara P, Kelly A. Evaluating the evidence for direct central nervous system invasion in patients infected with the nCOVID-19 virus. Interdiscip Neurosurg 2020; 22: 100829
  • 61 Moriguchi T, Harii N, Goto J. et al. A first case of meningitis/encephalitis associated with SARS-coronavirus-2. Int J Infect Dis 2020; 94: 55-58
  • 62 Solomon IH, Normandin E, Bhattacharyya S. et al. Neuropathological features of COVID-19. N Engl J Med 2020; 383 (10) 989-992
  • 63 Ye M, Ren Y, Lv T. Encephalitis as a clinical manifestation of COVID-19. Brain Behav Immun 2020; 88: 945-946
  • 64 Kantonen J, Mahzabin S, Mäyränpää MI. et al. Neuropathologic features of four autopsied COVID-19 patients. Brain Pathol 2020; 30 (06) 1012-1016
  • 65 Chen G, Wu D, Guo W. et al. Clinical and immunological features of severe and moderate coronavirus disease 2019. J Clin Invest 2020; 130 (05) 2620-2629
  • 66 Johansson A, Mohamed MS, Moulin TC, Schiöth HB. Neurological manifestations of COVID-19: a comprehensive literature review and discussion of mechanisms. J Neuroimmunol 2021; 358: 577658
  • 67 Lee MH, Perl DP, Nair G. et al. Microvascular injury in the brains of patients with COVID-19. N Engl J Med 2021; 384 (05) 481-483
  • 68 Gupta A, Madhavan MV, Sehgal K. et al. Extrapulmonary manifestations of COVID-19. Nat Med 2020; 26 (07) 1017-1032
  • 69 Cavallieri F, Sellner J, Zedde M, Moro E. Neurologic complications of coronavirus and other respiratory viral infections. Handb Clin Neurol 2022; 189: 331-358
  • 70 Monje M, Iwasaki A. The neurobiology of long COVID. Neuron 2022; 110 (21) 3484-3496
  • 71 Cecchetti G, Agosta F, Canu E. et al. Cognitive, EEG, and MRI features of COVID-19 survivors: a 10-month study. J Neurol 2022; 269 (07) 3400-3412
  • 72 Douaud G, Lee S, Alfaro-Almagro F. et al. SARS-CoV-2 is associated with changes in brain structure in UK Biobank. Nature 2022; 604 (7907): 697-707
  • 73 Bleck TP, Smith MC, Pierre-Louis SJ, Jares JJ, Murray J, Hansen CA. Neurologic complications of critical medical illnesses. Crit Care Med 1993; 21 (01) 98-103
  • 74 Jo S, Chang JY, Jeong S, Jeong S, Jeon SB. Newly developed stroke in patients admitted to non-neurological intensive care units. J Neurol 2020; 267 (10) 2961-2970
  • 75 Maas MB. Critical medical illness and the nervous system. Continuum (Minneap Minn) 2020; 26 (03) 675-694
  • 76 Naik-Tolani S, Oropello JM, Benjamin E. Neurologic complications in the intensive care unit. Clin Chest Med 1999; 20 (02) 423-434 , ix
  • 77 Hughson AV. Postviral neurological syndromes. Br Med J (Clin Res Ed) 1983; 287 (6406): 1717-1718
  • 78 Owens B. How “long COVID” is shedding light on postviral syndromes. BMJ 2022; 378: o2188
  • 79 Moldofsky H, Patcai J. Chronic widespread musculoskeletal pain, fatigue, depression and disordered sleep in chronic post-SARS syndrome; a case-controlled study. BMC Neurol 2011; 11: 37
  • 80 Lau ST, Yu WC, Mok NS, Tsui PT, Tong WL, Cheng SW. Tachycardia amongst subjects recovering from severe acute respiratory syndrome (SARS). Int J Cardiol 2005; 100 (01) 167-169
  • 81 Voiriot G, Oualha M, Pierre A. et al; la CRT de la SRLF. Chronic critical illness and post-intensive care syndrome: from pathophysiology to clinical challenges. Ann Intensive Care 2022; 12 (01) 58
  • 82 Marra A, Pandharipande PP, Girard TD. et al. Co-occurrence of post-intensive care syndrome problems among 406 survivors of critical illness. Crit Care Med 2018; 46 (09) 1393-1401
  • 83 Griffiths J, Hatch RA, Bishop J. et al. An exploration of social and economic outcome and associated health-related quality of life after critical illness in general intensive care unit survivors: a 12-month follow-up study. Crit Care 2013; 17 (03) R100
  • 84 Rawal G, Yadav S, Kumar R. Post-intensive care syndrome: an overview. J Transl Int Med 2017; 5 (02) 90-92
  • 85 Kamdar BB, Suri R, Suchyta MR. et al. Return to work after critical illness: a systematic review and meta-analysis. Thorax 2020; 75 (01) 17-27
  • 86 Mikkelsen ME, Still M, Anderson BJ. et al. Society of Critical Care Medicine's International Consensus Conference on Prediction and Identification of Long-Term Impairments After Critical Illness. Crit Care Med 2020; 48 (11) 1670-1679
  • 87 Rodriguez-Morales AJ, Cardona-Ospina JA, Gutiérrez-Ocampo E. et al; Latin American Network of Coronavirus Disease 2019-COVID-19 Research (LANCOVID-19). Electronic address: https://www.lancovid.org. Clinical, laboratory and imaging features of COVID-19: a systematic review and meta-analysis. Travel Med Infect Dis 2020; 34: 101623
  • 88 Hsieh SJ, Otusanya O, Gershengorn HB. et al. Staged implementation of awakening and breathing, coordination, delirium monitoring and management, and early mobilization bundle improves patient outcomes and reduces hospital costs. Crit Care Med 2019; 47 (07) 885-893
  • 89 Vrettou CS, Mantziou V, Vassiliou AG, Orfanos SE, Kotanidou A, Dimopoulou I. Post-intensive care syndrome in survivors from critical illness including COVID-19 patients: a narrative review. Life (Basel) 2022; 12 (01) 12
  • 90 Weidman K, LaFond E, Hoffman KL. et al. Post-intensive care unit syndrome in a cohort of COVID-19 survivors in New York City. Ann Am Thorac Soc 2022; 19 (07) 1158-1168
  • 91 Hodgson CL, Higgins AM, Bailey MJ. et al; COVID-Recovery Study Investigators and the ANZICS Clinical Trials Group. Comparison of 6-month outcomes of survivors of COVID-19 versus non-COVID-19 critical illness. Am J Respir Crit Care Med 2022; 205 (10) 1159-1168
  • 92 Ego A, Halenarova K, Creteur J, Taccone FS. How to manage withdrawal of sedation and analgesia in mechanically ventilated COVID-19 patients?. J Clin Med 2021; 10 (21) 10
  • 93 Chanques G, Constantin JM, Devlin JW. et al. Analgesia and sedation in patients with ARDS. Intensive Care Med 2020; 46 (12) 2342-2356
  • 94 Louzon P, Jennings H, Ali M, Kraisinger M. Impact of pharmacist management of pain, agitation, and delirium in the intensive care unit through participation in multidisciplinary bundle rounds. Am J Health Syst Pharm 2017; 74 (04) 253-262
  • 95 Morris PE, Griffin L, Berry M. et al. Receiving early mobility during an intensive care unit admission is a predictor of improved outcomes in acute respiratory failure. Am J Med Sci 2011; 341 (05) 373-377
  • 96 Alaparthi GK, Gatty A, Samuel SR, Amaravadi SK. Effectiveness, safety, and barriers to early mobilization in the intensive care unit. Crit Care Res Pract 2020; 2020: 7840743
  • 97 Fan E, Cheek F, Chlan L. et al; ATS Committee on ICU-acquired Weakness in Adults, American Thoracic Society. An official American Thoracic Society Clinical Practice guideline: the diagnosis of intensive care unit-acquired weakness in adults. Am J Respir Crit Care Med 2014; 190 (12) 1437-1446
  • 98 Bonorino KC, Cani KC. Early mobilization in the time of COVID-19 [in Portuguese]. Rev Bras Ter Intensiva 2020; 32 (04) 484-486
  • 99 AVERT Trial Collaboration Group. Efficacy and safety of very early mobilisation within 24 h of stroke onset (AVERT): a randomised controlled trial. Lancet 2015; 386 (9988): 46-55
  • 100 Liu K, Nakamura K, Kudchadkar SR. et al. Mobilization and rehabilitation practice in ICUs during the COVID-19 pandemic. J Intensive Care Med 2022; 37 (09) 1256-1264
  • 101 Valenzuela PL, Joyner M, Lucia A. Early mobilization in hospitalized patients with COVID-19. Ann Phys Rehabil Med 2020; 63 (04) 384-385
  • 102 Cao N, Barcikowski J, Womble F. et al. Efficacy of early inpatient rehabilitation of post COVID 19 survivors - single center retrospective analysis. Am J Phys Med Rehabil 2022
  • 103 Shabat S, Marmor A, Shiri S, Tsenter J, Meiner Z, Schwartz I. Correlations between disease severity and rehabilitation outcomes in patients recovering from COVID-19 infection. J Rehabil Med 2023; 55: jrm00344
  • 104 Maltser S, Trovato E, Fusco HN. et al. Challenges and lessons learned for acute inpatient rehabilitation of persons with COVID-19: clinical presentation, assessment, needs, and services utilization. Am J Phys Med Rehabil 2021; 100 (12) 1115-1123
  • 105 World Health Organization. Towards a Common Language for Functioning, Disability, and Health: ICF. The International Classification of Functioning, Disability and Health; 2002
  • 106 Prescott HC, Girard TD. Recovery from severe COVID-19: leveraging the lessons of survival from sepsis. JAMA 2020; 324 (08) 739-740
  • 107 Taylor SP, Chou SH, Sierra MF. et al. Association between adherence to recommended care and outcomes for adult survivors of sepsis. Ann Am Thorac Soc 2020; 17 (01) 89-97
  • 108 Claflin ES, Daunter AK, Bowman A. et al. Hospitalized patients with COVID-19 and neurological complications experience more frequent decline in functioning and greater rehabilitation needs. Am J Phys Med Rehabil 2021; 100 (08) 725-729
  • 109 Jaywant A, Toglia J, Gunning FM, O'Dell MW. Subgroups defined by the Montreal Cognitive Assessment differ in functional gain during acute inpatient stroke rehabilitation. Arch Phys Med Rehabil 2020; 101 (02) 220-226
  • 110 He J, Yang T. In the era of long COVID, can we seek new techniques for better rehabilitation?. Chronic Dis Transl Med 2022; 8 (03) 149-153
  • 111 Huang J, Fan Y, Zhao K. et al. Do patients with and survivors of COVID-19 benefit from telerehabilitation? A meta-analysis of randomized controlled trials. Front Public Health 2022; 10: 954754
  • 112 Sevin CM, Jackson JC. Post-ICU clinics should be staffed by ICU clinicians. Crit Care Med 2019; 47 (02) 268-272
  • 113 Meyer J, Brett SJ, Waldmann C. Should ICU clinicians follow patients after ICU discharge? Yes. Intensive Care Med 2018; 44 (09) 1539-1541
  • 114 Schwab K, Schwitzer E, Qadir N. Postacute sequelae of COVID-19 critical illness. Crit Care Clin 2022; 38 (03) 455-472
  • 115 Eaton TL, McPeake J, Rogan J, Johnson A, Boehm LM. Caring for survivors of critical illness: current practices and the role of the nurse in intensive care unit aftercare. Am J Crit Care 2019; 28 (06) 481-485
  • 116 Danesh V, Boehm LM, Eaton TL. et al. Characteristics of post-ICU and post-COVID recovery clinics in 29 U.S. Health Systems. Crit Care Explor 2022; 4 (03) e0658
  • 117 Madara J, Baram M. 805: Post-ICU syndrome clinics may decrease critical care provider burnout. Crit Care Med 2020; 48: 382