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CC BY 4.0 · Journal of Child Science 2023; 13(01): e40-e46
DOI: 10.1055/s-0043-1768463
Original Article

Electrical Status Epilepticus during Sleep: Risk Factors, Clinical Course, and Treatment Approaches

Iliyana Aleksandrova 
1   Clinic of Child Neurology, University Hospital for Active Treatment of Neurology and Psychiatry “St Naum,” Sofia, Bulgaria
2   Department of Neurology, Medical University of Sofia, Sofia, Bulgaria
,
Asya Asenova
1   Clinic of Child Neurology, University Hospital for Active Treatment of Neurology and Psychiatry “St Naum,” Sofia, Bulgaria
2   Department of Neurology, Medical University of Sofia, Sofia, Bulgaria
,
Petia Dimova
3   Epilepsy Surgery Center, University Hospital “St. Ivan Rilski,” Sofia, Bulgaria
,
Daniela Deneva
1   Clinic of Child Neurology, University Hospital for Active Treatment of Neurology and Psychiatry “St Naum,” Sofia, Bulgaria
,
Elena Rodopska
1   Clinic of Child Neurology, University Hospital for Active Treatment of Neurology and Psychiatry “St Naum,” Sofia, Bulgaria
,
Elena Slavkova
1   Clinic of Child Neurology, University Hospital for Active Treatment of Neurology and Psychiatry “St Naum,” Sofia, Bulgaria
,
Veneta Bojinova
1   Clinic of Child Neurology, University Hospital for Active Treatment of Neurology and Psychiatry “St Naum,” Sofia, Bulgaria
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Abstract

Background The efforts of clinicians are focused on determining the predictors for electrical status epilepticus in sleep (ESES) manifestation, due to the negative effect of ESES on cognition. Treatment approaches remain a leading problem because of therapeutic resistance.

Objective We looked for potential risk factors for ESES manifestation and summarize the clinical course and therapeutic approaches in patients with idiopathic and symptomatic ESES.

Patients and Methods We retrospectively reviewed the medical data of 51 children with idiopathic ESES and 20 children with symptomatic ESES.

Results We observed an earlier age of seizure onset (p = 0.0002) and a higher percentage of cases with multiple seizures (p < 0.00001) and with postictal paralysis (p < 0.00001) in idiopathic ESES compared with childhood epilepsy with centrotemporal spikes. In the idiopathic ESES, the treatment consisted of corticosteroids in patients with permanent ESES remission and transient remission, levetiracetam (LEV) children with permanent ESES remission and transient, clonazepam (CZP) children with permanent ESES remission and transient, ethosuximide (ESM), and sulthiame. The patients with symptomatic ESES had more unfavorable evolution, as 19 children had persistent or relapsing ESES course.

Conclusion We consider the earlier age of seizure onset (below 5 years) and the presence of multiple seizures and postictal paresis as risk factors for ESES manifestation. ESES is characterized by a significant therapeutic resistance, especially in the group of symptomatic cases. Good results are observed with LEV, ESM, CZP, and steroids.

Keywords

ESES - CECTS - sleep - corticosteroids - levetiracetam

Note

The authors state no conflict of interest and have received no payment in preparation of this manuscript. The paper has been read and approved by all the authors. Each author believes that the manuscript represents honest work and the requirements for authorship have been met.




Publication History

Received: 26 February 2023

Accepted: 20 March 2023

Article published online:
27 April 2023

© 2023. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution License, permitting unrestricted use, distribution, and reproduction so long as the original work is properly cited. (https://creativecommons.org/licenses/by/4.0/)

Georg Thieme Verlag KG
Rüdigerstraße 14, 70469 Stuttgart, Germany

 

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