CC BY-NC-ND 4.0 · Int Arch Otorhinolaryngol 2023; 27(02): e191-e196
DOI: 10.1055/s-0043-1768205
Original Research

Treatment Results of Vocal Process Granuloma: Intubation versus Contact Granuloma

1   Department of Otorhinolaryngology-Head and Neck Surgery, Gachon University College of Medicine, Gil Medical Center, Seongnam, South Korea
,
Jae Hwan Oh
1   Department of Otorhinolaryngology-Head and Neck Surgery, Gachon University College of Medicine, Gil Medical Center, Seongnam, South Korea
,
Byung Woo Lim
1   Department of Otorhinolaryngology-Head and Neck Surgery, Gachon University College of Medicine, Gil Medical Center, Seongnam, South Korea
,
Dong Young Kim
1   Department of Otorhinolaryngology-Head and Neck Surgery, Gachon University College of Medicine, Gil Medical Center, Seongnam, South Korea
› Institutsangaben

Abstract

Introduction Contact granulomas (CGs) and intubation granulomas (IGs) are known to have different clinical manifestations despite having the same pathological features.

Objective The purpose of the present study was to analyze the treatment results for CG and IG and to obtain clinical information.

Methods We retrospectively reviewed the medical records of patients diagnosed with vocal process granuloma (VPG) between January 2015 and December 2018. The patient's age, sex, medical history, lesion size, lesion type, reflux finding score (RFS), response to treatment, duration of treatment, and follow-up period were compared.

Results Eighteen patients with CG and 14 patients with IG were included in the study. The IG group had more female patients (p = 0.0009), showed better response to proton pump inhibitor (PPI) and steroid inhalation (SI) (p = 0.036), and had a shorter treatment period (p = 0.0029) than the CG group. Five patients who received botulinum toxin injections in their vocal cords had complete remission.

Conclusion Compared with CG, IG was more responsive to treatment with PPI and SI and required a shorter duration of treatment.



Publikationsverlauf

Eingereicht: 11. Juni 2020

Angenommen: 07. Januar 2021

Artikel online veröffentlicht:
28. April 2023

© 2023. Fundação Otorrinolaringologia. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/)

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  • References

  • 1 Hong-Gang D, He-Juan J, Chun-Quan Z, Guo-Kang F. Surgery and proton pump inhibitors for treatment of vocal process granulomas. Eur Arch Otorhinolaryngol 2013; 270 (11) 2921-2926
  • 2 Wang CT, Lai MS, Lo WC, Liao LJ, Cheng PW. Intralesional steroid injection: an alternative treatment option for vocal process granuloma in ten patients. Clin Otolaryngol 2013; 38 (01) 77-81
  • 3 Karkos PD, George M, Van Der Veen J. et al. Vocal process granulomas: a systematic review of treatment. Ann Otol Rhinol Laryngol 2014; 123 (05) 314-320
  • 4 Ylitalo R, Ramel S. Extraesophageal reflux in patients with contact granuloma: a prospective controlled study. Ann Otol Rhinol Laryngol 2002; 111 (5 Pt 1): 441-446
  • 5 Leonard R, Kendall K. Effects of voice therapy on vocal process granuloma: a phonoscopic approach. Am J Otolaryngol 2005; 26 (02) 101-107
  • 6 Martins RH, Branco A, Tavares EL, Iyomasa RM, Carvalho LR, Henry MA. Laryngeal and voice disorders in patients with gastroesophageal symptoms. Correlation with pH-monitoring. Acta Cir Bras 2012; 27 (11) 821-828
  • 7 Hillel AT, Lin LM, Samlan R, Starmer H, Leahy K, Flint PW. Inhaled triamcinolone with proton pump inhibitor for treatment of vocal process granulomas: a series of 67 granulomas. Ann Otol Rhinol Laryngol 2010; 119 (05) 325-330
  • 8 Rimoli CF, Martins RHG, Catâneo DC, Imamura R, Catâneo AJM. Treatment of post-intubation laryngeal granulomas: systematic review and proportional meta-analysis. Rev Bras Otorrinolaringol (Engl Ed) 2018; 84 (06) 781-789
  • 9 McFerran DJ, Abdullah V, Gallimore AP, Pringle MB, Croft CB. Vocal process granulomata. J Laryngol Otol 1994; 108 (03) 216-220
  • 10 Lee SW, Hong HJ, Choi SH. et al. Comparison of treatment modalities for contact granuloma: a nationwide multicenter study. Laryngoscope 2014; 124 (05) 1187-1191
  • 11 Lee DH, Yoon TM, Lee JK, Lim SC. Surgical treatment outcomes of vocal process granuloma after endotracheal intubation. J Craniofac Surg 2018; 29 (04) e387-e389
  • 12 Havas TE, Priestley J, Lowinger DS. A management strategy for vocal process granulomas. Laryngoscope 1999; 109 (2 Pt 1): 301-306
  • 13 Wani MK, Woodson GE. Laryngeal contact granuloma. Laryngoscope 1999; 109 (10) 1589-1593
  • 14 Roh HJ, Goh EK, Chon KM, Wang SG. Topical inhalant steroid (budesonide, Pulmicort nasal) therapy in intubation granuloma. J Laryngol Otol 1999; 113 (05) 427-432
  • 15 Wang CP, Ko JY, Wang YH, Hu YL, Hsiao TY. Vocal process granuloma - A result of long-term observation in 53 patients. Oral Oncol 2009; 45 (09) 821-825
  • 16 Nasri S, Sercarz JA, McAlpin T, Berke GS. Treatment of vocal fold granuloma using botulinum toxin type A. Laryngoscope 1995; 105 (06) 585-588
  • 17 Damrose EJ, Damrose JF. Botulinum toxin as adjunctive therapy in refractory laryngeal granuloma. J Laryngol Otol 2008; 122 (08) 824-828
  • 18 Yılmaz T, Kayahan B, Günaydın RÖ, Kuşçu O, Sözen T. Botulinum toxin A for treatment of contact granuloma. J Voice 2016; 30 (06) 741-743
  • 19 Yilmaz T, Süslü N, Atay G, Özer S, Günaydin RÖ, Bajin MD. Recurrent contact granuloma: experience with excision and botulinum toxin injection. JAMA Otolaryngol Head Neck Surg 2013; 139 (06) 579-583