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DOI: 10.1055/s-0043-1766129
Pregnancy and Acute Lymphoblastic Leukemia: A Case Series and Review of Literature
Funding None.![](https://www.thieme-connect.de/media/10.1055-s-00050348/EFirst/lookinside/thumbnails/10-1055-s-0043-1766129_221330819-1.jpg)
Abstract
Acute lymphoblastic leukemia (ALL) diagnosed during pregnancy is rare and causes ethical and therapeutic challenges. We performed a retrospective search of ALL patients (n = 202) treated at our institution from 2015 to 2020 and found five patients diagnosed during pregnancy. In this report, we discuss the individual patients in detail and the challenges faced during their treatment. The use of established lymphoblastic leukemia treatment protocols and the modifications made therein to prevent untoward chemotherapy-related toxicities to the fetus are discussed in this study. We report the second use of rasburicase during pregnancy in literature with favorable maternal and fetal outcomes. We also present an extensive literature review of 41 cases of ALL in pregnancy previously reported. It is important to note that there is a dearth of guidelines for the treatment of these complex situations, and although certain general principles can be established, an individualized approach is needed in most cases of leukemia diagnosed during pregnancy.
Keywords
acute leukemia - ethical considerations - pregnancy - maternal well-being - fetal outcome - chemotherapyAuthors' Contributions
S.B. was involved in conceptualization, data collection, and manuscript drafting. S.G. helped in conceptualization, clinical data curation, and manuscript editing and analysis. S.S.R., S. Samanta, N.S. and S. Saha were involved in Institutional Medical Boards convened for patient management strategies. M.B. was involved in conceptualization, manuscript editing, analysis, and overall supervision.
Ethics Approval
Retrospective study
Consent for Publication
Yes.
Availability of Data and Material
Available for publication/review.
Publikationsverlauf
Artikel online veröffentlicht:
17. Mai 2023
© 2023. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution License, permitting unrestricted use, distribution, and reproduction so long as the original work is properly cited. (https://creativecommons.org/licenses/by/4.0/)
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